Biography

Nikolaos Louros received his B.S. in Biology from the National and Kapodistrian University of Athens (NKUA), Greece, in 2011.  He completed his MSc in Bioinformatics in 2014. He earned his Ph.D. in 2016, working in the Department of Cell Biology and Biophysics at the NKUA, where he studied the self-assembly mechanism of various proteins associated with the formation of pathological and functional amyloids.

He joined the Switch lab at VIB-KU Leuven Center for Brain & Disease Research in Belgium as a post-doctoral scientist, where he developed several computational tools to define the energetic and structural principles behind protein aggregation and amyloid formation.  He completed his post-doctoral work studying determinants that govern amyloid structural plasticity (polymorphism) and  heterotypic amyloid interactions with other biomolecules. He has contributed to the development of independent therapeutic strategies for currently "undruggable" diseases. As the scientific operation of the Molecular Biophysics expertise unit at VIB-KU Leuven, he also developed innovative methods supporting the biophysical and structural investigation of biomolecular processes.

He joined UT Southwestern Medical Center as an Assistant Professor in 2023. With an affiliation to the Center for Alzheimer's and Neurodegenerative Diseases (CAND) and the Department of Biophysics, Dr. Louros's laboratory utilizes a hybrid apporach combining computational, biophysical, structural and biochemical approaches to investigate protein misfolding and aggregation, with emphasis in neurodegenerative diseases.  His group is particularly interested in integrating cutting-edge AI approaches with high-throughput experimental pipelines to study protein aggregation and to develop novel therapeutic/diagnostic agents.

The Louros lab adopts an inquiry-driven approach to science and seeks team members who are equally passionate about the pursuit of science with a translational impact. For more information, explore their lab website linked here: https://labs.utsouthwestern.edu/louros-lab

Research Interest

  • AI-based methods
  • Functional amyloids
  • Heterotypic amyloid interactions
  • Molecular Biophysics / Computational biology / Structural biology
  • Neurodegenerative diseases
  • Protein aggregation

Publications

Featured Publications LegendFeatured Publications

An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets.
Duverger W, Tsaka G, Khodaparast L, Khodaparast L, Louros N, Rousseau F, Schymkowitz J, J Nanobiotechnology 2024 Jul 22 1 406
CORDAX web server: An online platform for the prediction and 3D visualization of aggregation motifs in protein sequences.
Louros N, Rousseau F, Schymkowitz J, Bioinformatics 2024 Apr

Books

Featured Books Legend Featured Books

Exploring amyloidogenicity of clusterin: a structural and bioinformatics analysis. In Adv. Exp. Med. and Biol.

Paraskevi L Tsiolaki, Katerina C Nastou, Nikolaos Louros, Stavros J Hamodrakas, Vassiliki A Iconomidou (2017). Springer International Publishing

Honors & Awards

  • "Nikos Oikonomakos" Award
    (2014)
  • Endowed Scholar Award
    (2024-2029)
  • HSCBB15 Award
    Hellenic Society for Computational Biology & Bioinformatics Award (2015)
  • HSCBB16 Award
    Hellenic Society for Computational Biology & Bioinformatics Award (2016)
  • International Society of Amyloidosis (ISA) Presidential Award
    2024
  • Stichting Alzheimer's Onderzoek (SAO) Young investigator award
    (2021-2023)
  • Stichting Alzheimer's Onderzoek (SAO) Young investigator award
    (2023-2024)