Evan Noch, M.D., Ph.D.

Joined UT Southwestern: 2023

Dr. Evan Noch is the Director of Physician-Scientist Development in the Department of Neurology at the University of Texas Southwestern Medical Center.

Trainee Education: As the Director of Physician-Scientist Development, he also leads efforts for the Resident Research Track. 

Research: In his lab, Dr. Noch studies glioblastoma metabolism, with a focus on synergistic drug and dietary therapies targeting glucose utilization and redox pathways.  He received a K08 career development award from the National Institute of Neurological Disorders and Stroke for his work on targeting cysteine susceptibility in glioma.

Background: Dr. Noch earned his MD and PhD degrees from Temple University, where he completed his graduate studies in Biomedical Neuroscience with Kamel Khalili on the role of cellular and viral oncogenes in oxygen and glucose metabolism in malignant brain tumors.  

He went on to complete his residency in Neurology in the research track at Weill Cornell Medicine and fellowship in Neuro-oncology at Memorial Sloan Kettering Cancer Center.  He performed his post-doctoral studies in the lab of Lewis Cantley at Weill Cornell Medicine, where he studied nutrient metabolism in glioma. In his post-doctoral work, he demonstrated that insulin feedback is a targetable mechanism of resistance to PI3K inhibition in glioblastoma.  In separate work, he demonstrated that cysteine induces mitochondrial toxicity in glioma cells and in orthotopic glioblastoma mouse models. 

Awards: He is also the recipient of the Society for Neuro-oncology/Prime Oncology Young Investigator Award and the Excellence in Medical Education Award from Weill Cornell Medicine.

Leadership: Dr. Noch serves on the Board of Directors of the American Physician Scientists Association, the leading organization advocating for physician-scientist trainees.