Dr. Shirley (Jialiang) Wang is an Assistant Professor in the Charles Y.C. and Jane Pak Center for Mineral Metabolism and Clinical Research (CMMCR), the Department of Physiology and the Department of Internal Medicine at UT Southwestern Medical Center. She did her postdoctoral research in Dr. Marc Wein's group at Massachusetts General Hospital and Harvard Medical School supported by the NIH (NIDDK) NRSA T32 training grant. She is a recipient of the NIH (NIAMS) Pathway to Independence Awards (K99/R00).


The Wang laboratory takes an interdisciplinary approach that spans genetics, multi-omics, in vivo and in vitro models, to characterize how aberrant factors can lead to skeletal disease and bone cancer. Ongoing projects 1) investigate the molecular programs that regulate the osteoblast-to-osteocyte transition and bridge the gap between osteocyte development and human skeletal disease, and 2) reveal the regulatory role of transcription factors in bone cancer and develop novel transcription factor-targeted therapies.


Research Interest

  • Multiomics
  • Osteocyte
  • Osteoporosis
  • Osteosarcoma
  • Transcription regulation


Featured Publications LegendFeatured Publications

Selective reduction of visceral adipose tissue with injectable ice slurry.
Moradi Tuchayi S, Khachatryan Y, Wang Y, Rox Anderson R, Wang JS, Wein MN, Garibyan L, Sci Rep 2023 Sep 13 1 16350
A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis.
Yoon SH, Meyer MB, Arevalo C, Tekguc M, Zhang C, Wang JS, Castro Andrade CD, Strauss K, Sato T, Benkusky NA, Lee SM, Berdeaux R, Foretz M, Sundberg TB, Xavier RJ, Adelmann CH, Brooks DJ, Anselmo A, Sadreyev RI, Rosales IA, Fisher DE, Gupta N, Morizane R, Greka A, Pike JW, Mannstadt M, Wein MN, J Clin Invest 2023 May 133 9
SP7: from Bone Development to Skeletal Disease.
Wang JS, Tokavanich N, Wein MN, Curr Osteoporos Rep 2023 Apr 21 2 241-252
Pathways Controlling Formation and Maintenance of the Osteocyte Dendrite Network.
Wang JS, Wein MN, Curr Osteoporos Rep 2022 Dec 20 6 493-504
Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy.
Mazur CM, Castro Andrade CD, Tokavanich N, Sato T, Bruce M, Brooks DJ, Bouxsein ML, Wang JS, Wein MN, iScience 2022 Sep 25 9 105019
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN, Nat Commun 2021 Nov 12 1 6271
Role of histone deacetylases in bone development and skeletal disorders.
Wang JS, Yoon SH, Wein MN, Bone 2021 Feb 143 115606
Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones.
Wang JS, Mazur CM, Wein MN, Front Endocrinol (Lausanne) 2021 12 584147
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.
Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN, Nat Commun 2020 Jul 11 1 3282
PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets.
Wang JS, Infante CR, Park S, Menke DB Dev. Biol. 2018 Feb 434 1 186-195

Honors & Awards

  • ASBMR Pre-Meeting Young Investigator Travel Award
    American Society for Bone and Mineral Research (ASBMR) (2023)
  • AIMM/ASBMR John Haddad Young Investigator Award
    Advances in Mineral Metabolism (AIMM) and American Society of Bone and Mineral Research (ASBMR) (2022)
  • ASBMR Harold M. Frost Young Investigator Award
    American Society for Bone and Mineral Research (ASBMR) (2022)
  • ASBMR Young Investigator Award
  • ASBMR Young Investigator Travel Award

Professional Associations/Affiliations

  • Advances in Mineral Metabolism (AIMM) (2022)
  • American Society of Bone and Mineral Research (ASBMR) (2018)
  • Orthopaedic Research Society (ORS) (2022)