Mangyu Choe, Ph.D. Titles and Appointments Assistant Professor School Medical School Department Children's Medical Center Research Institute at UT Southwestern | Pediatrics Biography Mangyu Choe, Ph.D., earned his bachelor’s in biology from Seoul National University in South Korea. He stayed to complete his master’s and Ph.D. in microbial physiology. During his training, he worked on unveiling the underlying molecular mechanism of glucose preference over other carbon sources in Escherichia coli, simply known as Carbon Catabolite Repression (CCR). He then joined Denis Titov's lab at UC Berkeley as a postdoctoral fellow, where he developed a data-driven mathematical model and a genetic tool to study metabolism. Dr. Choe joined the Children's Medical Center Research Institute at UT Southwestern (CRI) in 2024 as a research assistant professor. He is now focusing on developing and applying genetic tools to study inter-organelle communications. Research Interest Genetically encoded tools for manipulation of metabolism (GEMMs) Integrated stress response ISR Mitochondrial membrane potential Redox metabolism UCP1 Publications Featured Publications Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction. Choe M, Ekvik AE, Stalnaker G, Shin HR, Titov DV, Cell Chem Biol 2025 Apr 32 4 620-630.e6 Glycolysis model shows that allostery maintains high ATP and limits accumulation of intermediates. Choe M, Einav T, Phillips R, Titov DV, Biophys J 2025 Apr Genetically encoded tools for measuring and manipulating metabolism. Choe M, Titov DV, Nat Chem Biol 2022 May 18 5 451-460 A Cellular Mechanism to Detect and Alleviate Reductive Stress. Manford AG, Rodríguez-Pérez F, Shih KY, Shi Z, Berdan CA, Choe M, Titov DV, Nomura DK, Rape M, Cell 2020 Oct 183 1 46-61.e21 Structural insight into glucose repression of the mannitol operon. Choe M, Min H, Park YH, Kim YR, Woo JS, Seok YJ, Sci Rep 2019 Sep 9 1 13930 The general PTS component HPr determines the preference for glucose over mannitol. Choe M, Park YH, Lee CR, Kim YR, Seok YJ, Sci Rep 2017 Feb 7 43431 HPr antagonizes the anti-σ70 activity of Rsd in Escherichia coli. Park YH, Lee CR, Choe M, Seok YJ, Proc Natl Acad Sci U S A 2013 Dec 110 52 21142-7 Results 1-7 of 7 1 Professional Associations/Affiliations Children's Medical Center Research Institute at UT Southwestern
