Biography

Research Interest

  • Innate Immunity, mucosal immunology, Immunometabolism, post-translational regulation, long noncoding RNAs, Inflammatory diseases, Infectious diseases

Publications

Lnc-ing RNA to intestinal homeostasis and inflammation
Fitzgerald KA, Shmuel-Galia L Trends in Immunology 2024 Feb 45 127-137
Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease
Johnson JL, Sargsyan D, Neiman EM, Hart A, Stojmirovic A, Kosoy R, Irizar H, Suárez-Fariñas M, Song WM, Argmann C, Avey S, Shmuel-Galia L, Vierbuchen T, Bongers G, Sun Y, Edelstein L, Perrigoue J, Towne JE, O’Hara Hall A, Fitzgerald KA, Hoebe K JCI Insight 2024 9
The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis
Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton JM, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA Cell Metabolism 2023 Aug 35 1441-1456.e9
The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2
Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, Hall AO, Hoebe K, Fitzgerald KA Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 120
Targeting STING oligomerization with small-molecule inhibitors
Humphries F, Shmuel-Galia L, Jiang Z, Zhou JY, Barasa L, Mondal S, Wilson R, Sultana N, Shaffer SA, Ng SL, Pesiridis GS, Thompson PR, Fitzgerald KA Proceedings of the National Academy of Sciences of the United States of America 2023 120
Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules
Lei X, Ketelut-Carneiro N, Shmuel-Galia L, Xu W, Wilson R, Vierbuchen T, Chen Y, Reboldi A, Kang J, Edelblum KL, Ward D, Fitzgerald KA Journal of Experimental Medicine 2022 Aug 219
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton JM, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA Immunity 2021 Jun 54 1137-1153.e8
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
Humphries F, Shmuel-Galia L, Jiang Z, Wilson R, Landis P, Ng SL, Parsi KM, Maehr R, Cruz J, Morales-Ramos A, Ramanjulu JM, Bertin J, Pesiridis GS, Fitzgerald KA Science Immunology 2021 May 6
Succination inactivates gasdermin D and blocks pyroptosis
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA Science 2020 Sep 369
TLR2 dimerization blockade allows generation of homeostatic intestinal macrophages under acute colitis challenge
Gross-Vered M, Shmuel-Galia L, Zarmi B, Humphries F, Thaiss C, Salame TM, David E, Chappell-Maor L, Fitzgerald KA, Shai Y, Jung S Journal of Immunology 2020 Feb 204 707-717

Honors & Awards

  • FISEB Travel Award, ILANIT meeting, Eilat, Israel
    (2023)
  • The Robert W. Finberg, MD Memorial Research Training Award, UMass Chan Medical School
    (2023)
  • Milstein Travel Award, The 10th Annual Meeting of the International Cytokine & Interferon Society, Hawaii, USA
    (2022-2022)
  • The Crohns and Colitis Foundation of America Career Development Award
    (2022-2023)
  • FISEB Travel Award, ILANIT meeting, Eilat, Israel
    (2020-2020)
  • The Crohns and Colitis Foundation of America Research Award
    (2020-2022)
  • Milstein Travel Award, The 7th Annual Meeting of the International Cytokine & Interferon Society, Vienna Austria
    (2019-2019)
  • EMBO Long-Term Fellowship
    (2018-2019)
  • Ph.D. Fellowship at the Feinberg Graduate School, The Weizmann Institute of Science, Rehovot, Israel
    (2012-2017)
  • M.Sc. Fellowship at the Feinberg Graduate School, The Weizmann Institute of Science, Rehovot, Israel
    (2009-2011)
  • B.Sc. in Life Science, Summa Cum Laude, Bar Ilan University, Ramat Gan, Israel
    (2006-2009)