Liraz Galia, Ph.D.

Download Curriculum Vitae

• Innate Immunity, mucosal immunology, Immunometabolism, post-translational regulation, long noncoding RNAs, Inflammatory diseases, Infectious diseases

Featured Publications

Targeting STING oligomerization with small-molecule inhibitors.

Humphries F, Shmuel-Galia L, Jiang Z, Zhou JY, Barasa L, Mondal S, Wilson R, Sultana N, Shaffer SA, Ng SL, Pesiridis GS, Thompson PR, Fitzgerald KA, Proc Natl Acad Sci U S A 2023 Aug 120 33 e2305420120

The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.

Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA, Cell Metab 2023 Aug 35 8 1441-1456.e9

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.

Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA, Proc Natl Acad Sci U S A 2023 Jan 120 1 e2213715120

Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.

Lei X, Ketelut-Carneiro N, Shmuel-Galia L, Xu W, Wilson R, Vierbuchen T, Chen Y, Reboldi A, Kang J, Edelblum KL, Ward D, Fitzgerald KA, J Exp Med 2022 Aug 219 8

Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.

Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA, Immunity 2021 Jun 54 6 1137-1153.e8

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection.

Humphries F, Shmuel-Galia L, Jiang Z, Wilson R, Landis P, Ng SL, Parsi KM, Maehr R, Cruz J, Morales-Ramos A, Ramanjulu JM, Bertin J, Pesiridis GS, Fitzgerald KA, Sci Immunol 2021 May 6 59

Succination inactivates gasdermin D and blocks pyroptosis.

Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA, Science 2020 Sep 369 6511 1633-1637

TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.

Gross-Vered M, Shmuel-Galia L, Zarmi B, Humphries F, Thaiss C, Salame TM, David E, Chappell-Maor L, Fitzgerald KA, Shai Y, Jung S, J Immunol 2020 Feb 204 3 707-717

The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice.

Rotem E, Faingold O, Charni M, Klug YA, Harari D, Shmuel-Galia L, Nudelman A, Rotter V, Shai Y, PLoS Pathog 2018 May 14 5 e1007044

Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.

Shmuel-Galia L, Klug Y, Porat Z, Charni M, Zarmi B, Shai Y, J Biol Chem 2017 Aug 292 32 13415-13427

• FISEB Travel Award, ILANIT meeting, Eilat, Israel
  (2023)
• The Robert W. Finberg, MD Memorial Research Training Award, UMass Chan Medical School
  (2023)
• Milstein Travel Award, The 10th Annual Meeting of the International Cytokine & Interferon Society, Hawaii, USA
  (2022-2022)
• The Crohns and Colitis Foundation of America Career Development Award
  (2022-2023)
• FISEB Travel Award, ILANIT meeting, Eilat, Israel
  (2020-2020)
• The Crohns and Colitis Foundation of America Research Award
  (2020-2022)
• Milstein Travel Award, The 7th Annual Meeting of the International Cytokine & Interferon Society, Vienna Austria
  (2019-2019)
• EMBO Long-Term Fellowship
  (2018-2019)
• Ph.D. Fellowship at the Feinberg Graduate School, The Weizmann Institute of Science, Rehovot, Israel
  (2012-2017)
• M.Sc. Fellowship at the Feinberg Graduate School, The Weizmann Institute of Science, Rehovot, Israel
  (2009-2011)
• B.Sc. in Life Science, Summa Cum Laude, Bar Ilan University, Ramat Gan, Israel
  (2006-2009)