Pranavkumar Shivakumar, Ph.D. Associate Professor School Medical School Department Pediatrics Biography Dr. Pranav Shivakumar, Ph.D., is an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center and Director of the Biliary Atresia Research and Cure Center in the Division of Pediatric Gastroenterology, Hepatology, and Nutrition. He earned his diploma and bachelor’s degree in pharmaceutical sciences from Karnataka University, Dharwad, India, and his master’s and Ph.D. in technology from the University Institute of Chemical Technology, University of Mumbai, India, where he earned junior and senior scholarships from the government of India. Dr. Shivakumar completed his post-doctoral fellowship and training in pediatric hepatology with a specific focus on biliary atresia at Cincinnati Children’s Hospital Medical Center. He then joined the Division of Gastroenterology, Hepatology, and Nutrition, and the Department of Pediatrics at the University of Cincinnati College of Medicine and established research programs to investigate mechanisms of biliary atresia pathogenesis. Dr. Shivakumar’s research focuses on understanding how innate and adaptive immune systems independently, and in concert, orchestrate to induce bile duct epithelial injury, inflammation, and atresia (complete absence of duct lumen). The goal of his research is to better understand the mechanisms of biliary disease and develop novel therapeutics to promote long-term native liver survival in infants with biliary atresia. To understand the early processes of epithelial injury, duct inflammation, and blockade, his laboratory has developed neonatal mouse models of biliary atresia and liver fibrosis induced by virus and toxins as well as organoids from mouse and patient liver tissue. Dr. Shivakumar is dedicated to promoting scientific training and education. He has mentored a large number of post-doctoral and clinical fellows, research personnel, and undergraduate and medical students who have successfully established their careers in medicine and other fields. Dr. Shivamkumar continues to work with medical students and gastrointestinal and hepatology fellows to further biliary atresia research and education. Research Interest Biliary atresia Cholangiopathies Complement biology Inflammation in the liver: Innate and adaptive immunology Neonatal Cholestasis Organoid technology Toxins in bile duct epithelial injury Publications Featured Publications Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia. Mohanty SK, Shivakumar P, Sabla G, Bezerra JA, BMC Gastroenterol 2006 Apr 6 14 Analysis of the biliary transcriptome in experimental biliary atresia. Carvalho E, Liu C, Shivakumar P, Sabla G, Aronow B, Bezerra JA, Gastroenterology 2005 Aug 129 2 713-7 Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA, J Clin Invest 2004 Aug 114 3 322-9 Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Shneider BL, Aronow B, Bezerra JA, Hepatology 2004 Apr 39 4 954-62 Results 1-4 of 4 1 Honors & Awards Invited Speaker, International Symposium on Drug Discovery and Process Research (2006) Best Poster Award, DDRDC Scientific Retreat and External Advisory Board Meeting (2005) Travel Award, American Association for the Study of Liver Diseases, Boston, MA (2004) Travel Award, Mead Johnson Nutritionals (2004) Travel Award, American Association for the Study of Liver Diseases, Boston, MA (2003) Travel Award, Pediatric Academic Society, Seattle, WA (2003) Govt. of India UGC Senior Research Fellowship Award (1998) Academic Achievement Award, Indian Drug Manufacturers' Association (1996) Gold Medal, Bachelor's in Pharmacy, KLE University, Belgaum,India (1995) Govt. of India UGC Junior Research Fellowship Award (1995) Gold Medal, Diplomate in Pharmacy, KLE University, Belgaum, India (1990) Professional Associations/Affiliations American Association for the Study of Liver Diseases (2004) American Association of Pharmaceutical Scientists (2010) American Chemical Society (2014) American Gastroenterological Association (2012) American Society for Microbiology (2014) Indian Pharmaceutical Association (2002) International Complement Society (2008) North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) Sigma Xi (2022) Society for Pediatric Research (2012)
