Biography

Jorge A. Bezerra, M.D., joined UT Southwestern as Chair of the Department of Pediatrics in October 2022. He is also Pediatrician-in-Chief at Children’s Medical Center Dallas. 

A pediatric gastroenterologist, Dr. Bezerra earned his medical degree from the Federal University of Rio Grande do Norte School of Medicine in Brazil. After a pediatrics residency at the University of Arizona Health Sciences Center, he completed clinical and research fellowships in pediatric gastroenterology, hepatology, and nutrition at CCHMC.

Dr. Bezerra is the principal investigator of multiple grants from the National Institutes of Health focused on preclinical and translational research on biliary atresia, the most common cause of chronic liver disease in children. 

His scientific achievements include the discovery of a key immunologic signature in the liver of children with biliary atresia. Using predictive analytics, the Bezerra lab identified matrix metalloproteinase-7 (MMP-7) as a diagnostic biomarker of biliary atresia. The discovery led to a test now transitioning to clinical use to facilitate diagnostic algorithms and shorten the time to surgical treatment.

Dr. Bezerra is an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He is also a Fellow of the American Gastroenterological Association and served as the 71st President of the American Association for the Study of Liver Diseases in 2020. He currently serves as Chairman of the Board of Scientific Counselors of the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Education

Medical School
Federal University of Rio Grande Do Sul - Brazil (1984)
Residency
University of Arizona Health Sciences Center (1989), Pediatrics
Fellowship
Cincinnati Children's Hospital Medical Center (1993), Pediatric Gastroenterology

Research Interest

  • Biliary Atresia
  • Cholestatic Liver Diseases
  • Inherited Liver Diseases
  • Viral Hepatitis

Publications

Featured Publications LegendFeatured Publications

Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia.
Russi AE, Shivakumar P, Luo Z, Bezerra JA, Hepatology 2023 Oct 78 4 1035-1049
Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report.
Pandurangi S, Kim S, Asai A, Bondoc A, Balistreri W, Campbell K, Miethke A, Peters A, Rogers M, Taylor A, Attia SL, Gibbons T, Mullapudi B, Sheridan R, Tiao G, Bezerra JA, J Pediatr Surg 2023 Aug 58 8 1483-1488
Serum Bile Acids as a New Prognostic Biomarker in Biliary Atresia Following Kasai Portoenterostomy.
Harpavat S, Hawthorne K, Setchell KDR, Narvaez Rivas M, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP, Rosenthal P, Thompson RJ, Wang KS, Sokol RJ, Shneider BL, Hepatology 2022 Sep
Serum Biomarkers Correlated with Liver Stiffness Assessed in a Multi-center Study of Pediatric Cholestatic Liver Disease.
Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen S, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Hepatology 2022 Sep
Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases-Examination of cholestatic liver disease in Alagille syndrome.
Shneider BL, Kamath BM, Magee JC, Goodrich NP, Loomes KM, Ye W, Spino C, Alonso EM, Molleston JP, Bezerra JA, Wang KS, Karpen SJ, Horslen SP, Guthery SL, Rosenthal P, Squires RH, Sokol RJ, Hepatol Commun 2022 Aug 6 8 1910-1921
Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia.
Osborn J, Mourya R, Thanekar U, Su W, Fei L, Shivakumar P, Bezerra JA, Hepatol Commun 2022 05 6 5 995-1004
The Liver Biopsy in Neonatal Cholestasis: Just a Cherry on Top?
Russi AE, Pandurangi S, Bezerra JA, Clin Liver Dis (Hoboken) 2022 Mar 19 3 111-113
Maternal regulation of biliary disease in neonates via gut microbial metabolites.
Jee JJ, Yang L, Shivakumar P, Xu PP, Mourya R, Thanekar U, Yu P, Zhu Y, Pan Y, Wang H, Duan X, Ye Y, Wang B, Jin Z, Liu Y, Cao Z, Watanabe-Chailland M, Romick-Rosendale LE, Wagner M, Fei L, Luo Z, Ollberding NJ, Tang ST, Bezerra JA, Nat Commun 2022 01 13 1 18
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Amarachintha SP, Mourya R, Ayabe H, Yang L, Luo Z, Li X, Thanekar U, Shivakumar P, Bezerra JA, Hepatology 2022 01 75 1 89-103
The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence.
Ghany MG, Lok ASF, Dienstag JL, Feinstone SM, Hoofnagle JH, Jake Liang T, Seeff LB, Cohen DE, Bezerra JA, Chung RT, Hepatology 2021 11 74 5 2813-2823

Books

Featured Books Legend Featured Books

Honors & Awards

  • Chairman
    Board of Scientific Councilors, Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (2021)
  • Honorary Member
    Academy of Medicine, Federal University of Rio Grande do Norte School of Medicine, Natal, Brazil (2021)
  • The Klatskin Lecturer
    Yale University (2021)
  • President
    American Association for the Study of Liver Diseases (2020)
  • Castle Conolly Top Doctors in America
    (2018-2021)
  • Chairman
    National Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, ZRG1 DKUS-P (03) (2017)
  • Councilor and Governing Board Member
    American Association for the Study of Liver Diseases (2016)
  • Trustee
    Foundation of the American Association for the Study of Liver Diseases (2016-2018)
  • Fellow
    American Gastroenterological Association (2015)
  • Award for distinguished scientific accomplishments
    15th Brazilian Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Natal, Brazil (2014)
  • Fellow
    American Association for the Study of Liver Diseases (2014)
  • Mentorship Achievement Award
    Cincinnati Children’s Hospital Medical Center (2014)
  • Associate Editor
    Hepatology (2012)
  • William and Rebecca Balistreri Chair of Pediatric Hepatology
    Cincinnati Children’s Hospital Medical Center (2009-2022)
  • The Best Doctors in America
    2005 (2008-2021)
  • Graduating Resident Award for Excellence in Clinical Service
    Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ (1989)
  • Graduating Resident Award for Excellence in Research
    Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ (1989)
  • Graduating Resident Award for Excellence in Teaching
    Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ (1989)
  • Pediatric Resident Research Award
    American Academy of Pediatrics (1989)
  • Best Graduating Student, Merit Medal
    Federal University of Rio Grande do Norte School of Medicine (1984)
  • Top Doctor, Pediatrics
    2014-2015, 2017-2021, Cincinnati Magazine

Professional Associations/Affiliations

  • American Association for Advancement of Science (2000)
  • American Association for Studies of Liver Diseases (1994)
  • American Association for Studies of Liver Diseases, Fellow (2014)
  • American Association of Physicians (2015)
  • American Gastroenterological Association (1994)
  • American Gastroenterological Association, Fellow (2015)
  • American Pediatric Society (2005)
  • American Physiological Society (2003)
  • American Society for Clinical Investigation (2005)
  • North American Society for Pediatric Gastroenterology and Nutrition (1994)
  • Society for Pediatric Research (2000)