Jorge Bezerra, M.D. Titles and Appointments Professor & Chair Endowed Title Robert L. Moore Chair in Pediatrics School Medical School Department Pediatrics Graduate Programs Immunology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Jorge A. Bezerra, M.D., joined UT Southwestern as Chair of the Department of Pediatrics in October 2022. He is also Pediatrician-in-Chief at Children’s Medical Center Dallas. A pediatric gastroenterologist, Dr. Bezerra earned his medical degree from the Federal University of Rio Grande do Norte School of Medicine in Brazil. After a pediatrics residency at the University of Arizona Health Sciences Center, he completed clinical and research fellowships in pediatric gastroenterology, hepatology, and nutrition at CCHMC. Dr. Bezerra is the principal investigator of multiple grants from the National Institutes of Health focused on preclinical and translational research on biliary atresia, the most common cause of chronic liver disease in children. His scientific achievements include the discovery of a key immunologic signature in the liver of children with biliary atresia. Using predictive analytics, the Bezerra lab identified matrix metalloproteinase-7 (MMP-7) as a diagnostic biomarker of biliary atresia. The discovery led to a test now transitioning to clinical use to facilitate diagnostic algorithms and shorten the time to surgical treatment. Dr. Bezerra is an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He is also a Fellow of the American Gastroenterological Association and served as the 71st President of the American Association for the Study of Liver Diseases in 2020. He currently serves as Chairman of the Board of Scientific Counselors of the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Education Medical School Federal University of Rio Grande Do Sul - Brazil (1984) Residency University of Arizona Health Sciences Center (1989), Pediatrics Fellowship Cincinnati Children's Hospital Medical Center (1993), Pediatric Gastroenterology Research Interest Biliary Atresia Cholestatic Liver Diseases Inherited Liver Diseases Viral Hepatitis Publications Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids Ayabe H, DePasquale EA, Amarachintha SP, Mourya R, Li W, Nalluri S, Fox SR, Konishi K, Shivakumar P, Bezerra JA Nature communications 2025 Dec 16 Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage Author Collaboration ft, Taylor SA, Harpavat S, Gromer KD, Andreev V, Loomes KM, Bezerra JA, Jarasvaraparn C, Wang K, Horslen S, Rosenthal P, Teckman J, Valentino PL, Ng VL, Karpen SJ, Sokol RJ, Alonso EM, Mack CL Pediatric Research 2025 Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort Author Collaboration TC, Pandurangi S, Mourya R, Nalluri S, Fei L, Dong S, Harpavat S, Guthery SL, Molleston JP, Rosenthal P, Sokol RJ, Wang KS, Ng V, Alonso EM, Hsu EK, Karpen SJ, Loomes KM, Magee JC, Shneider BL, Horslen SP, Teckman JH, Bezerra JA Hepatology 2024 Jul 80 152-162 Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia Russi AE, Shivakumar P, Luo Z, Bezerra JA Hepatology 2023 Oct 78 1035-1049 Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report Pandurangi S, Kim S, Asai A, Bondoc A, Balistreri W, Campbell K, Miethke A, Peters A, Rogers M, Taylor A, Attia SL, Gibbons T, Mullapudi B, Sheridan R, Tiao G, Bezerra JA Journal of Pediatric Surgery 2023 Aug 58 1483-1488 Recent Increase in Incidence of Severe Acute Hepatitis of Unknown Etiology in Children is Associated with Infection with Adenovirus and Other Nonhepatotropic Viruses Peters AL, Kim S, Mourya R, Asai A, Taylor A, Rogers M, Campbell K, Fei L, Miethke A, Balistreri WF, Bezerra JA Journal of Pediatrics 2023 Aug 259 Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children Author Collaboration tC, Squires JE, Miethke AG, Alexander Valencia C, Hawthorne K, Henn L, Van Hove JL, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ Hepatology Communications 2023 Jun 7 Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy Harpavat S, Hawthorne K, Setchell KD, Rivas MN, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP, Rosenthal P, Thompson RJ, Wang KS, Sokol RJ, Shneider BL Hepatology 2023 Mar 77 862-873 Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease Author Collaboration TC, Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM Hepatology 2023 Feb 77 530-545 Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency Author Collaboration tN, Felzen A, van Wessel DB, Gonzales E, Thompson RJ, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipiński P, Czubkowski P, Rock N, Shagrani M, Broering D, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JB, Serranti D, Arikan C, Polat E, Debray D, Lacaille F, Goncalves C, Hierro L, Muñoz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsőfi A, Calvo PL, Grabhorn E, Hartleif S, van der Woerd WJ, Kamath BM, Wang JS, Li L, Durmaz Ö, Kerkar N, Jørgensen MH, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Bezerra JA JHEP Reports 2023 Feb 5 Results 1-10 of 162 1 2 3 4 5 Next Last Books Featured Books Transplantation of the liver. In Transplantation for cholestatic liver disease Bezerra JA, Balistreri W (1996). Philadelphia, W.B. Saunders Co Metabolic diseases in children. In Liver Diseases D?Agata I, Bezerra JA. (2001). Brazil, Editora Atheneu Metabolic liver disease. In Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento Bezerra JA (2003). Rio de Janeiro, Brazil, Medsi Neonatal cholestasis. In Gastroenterologia e Hepatologia em Pediatria. Bezerra JA (2003). Rio de Janeiro, Brazil, Medsi Endoscopia Pediatrica (Pediatric Endoscopy). In Gastrointestinal evaluation in immunodeficient children Guthery S, Bezerra JA (2004). Rio de Janeiro, RJ, Brazil, Guanabara Koogan Biliary atresia. In Textbook of Pediatric Gatrointestinal Disease: 4th Edition, Volume 2 Campbell K, Bezerra JA. (2004). Lewiston, NY, BC Decker Diagnosis and management of acute diarrhea in children. In Current Opinion in Pediatrics Bezerra JA, Cohen MB (1991). United States, Wolters Kluwer Cirrhosis. In Current Pediatric Therapy Bezerra JA, Balistreri W (1993). Philadelphia, W.B. Saunders Co Progress in pediatric hepatology. In Current Opinion in Gastroenterology Bezerra JA, Balistreri WF (1996). United States, Wolters Kluwer Cell transplantation into transgenic mice. In Falk Symposium Bezerra JA (2002). Springer Dordrecht Biliary atresia. In National Organization of Rare Disorders: A guide to rare disorders Bezerra JA (2002). Lippincott Williams & Wilkins Honors & Awards ChairmanBoard of Scientific Councilors, Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (2021) Honorary MemberAcademy of Medicine, Federal University of Rio Grande do Norte School of Medicine, Natal, Brazil (2021) The Klatskin LecturerYale University (2021) PresidentAmerican Association for the Study of Liver Diseases (2020) Castle Conolly Top Doctors in America (2018-2021) ChairmanNational Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, ZRG1 DKUS-P (03) (2017) Councilor and Governing Board MemberAmerican Association for the Study of Liver Diseases (2016) TrusteeFoundation of the American Association for the Study of Liver Diseases (2016-2018) FellowAmerican Gastroenterological Association (2015) Award for distinguished scientific accomplishments15th Brazilian Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Natal, Brazil (2014) FellowAmerican Association for the Study of Liver Diseases (2014) Mentorship Achievement AwardCincinnati Childrens Hospital Medical Center (2014) Associate EditorHepatology (2012) William and Rebecca Balistreri Chair of Pediatric HepatologyCincinnati Childrens Hospital Medical Center (2009-2022) The Best Doctors in America2005 (2008-2021) Graduating Resident Award for Excellence in Clinical ServiceDepartment of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ (1989) Graduating Resident Award for Excellence in ResearchDepartment of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ (1989) Graduating Resident Award for Excellence in TeachingDepartment of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ (1989) Pediatric Resident Research AwardAmerican Academy of Pediatrics (1989) Best Graduating Student, Merit MedalFederal University of Rio Grande do Norte School of Medicine (1984) Top Doctor, Pediatrics2014-2015, 2017-2021, Cincinnati Magazine Professional Associations/Affiliations American Association for Advancement of Science (2000) American Association for Studies of Liver Diseases (1994) American Association for Studies of Liver Diseases, Fellow (2014) American Association of Physicians (2015) American Gastroenterological Association (1994) American Gastroenterological Association, Fellow (2015) American Pediatric Society (2005) American Physiological Society (2003) American Society for Clinical Investigation (2005) North American Society for Pediatric Gastroenterology and Nutrition (1994) Society for Pediatric Research (2000)
