William Swindell, D.O., Ph.D.

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William Swindell, D.O., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Hospital Medicine Division. His clinical interests include general internal medicine, geriatric medicine, and endocrinology.

Originally from Cleveland, Ohio, Dr. Swindell holds a bachelor's degree and a doctorate in biology from Bowling Green State University in Bowling Green, Ohio, and a master's degree in statistics from Michigan State University in East Lansing, Michigan. He completed postdoctoral research studies at the University of Michigan in Ann Arbor, Michigan, Brigham & Women's Hospital in Boston, Massachusetts, and at Harvard Medical School. He received his medical degree from the Ohio University Heritage College of Osteopathic Medicine in Athens, Ohio, and then completed internal medicine residency training at The Jewish Hospital — Mercy Health in Cincinnati, Ohio.

Dr. Swindell's research interests include bioinformatics, health data analytics, and inflammatory mechanisms of aging and disease. His investigations have resulted in more than 90 publications in peer-reviewed journals, and his findings have been presented at scientific conferences throughout the U.S. and around the world. 

Dr. Swindell is active in professional societies such as the American College of Physicians and Texas Medical Association.

Outside of medicine, Dr. Swindell enjoys traveling, exercising, sports, and spending time with family.

Graduate School

Bowling Green State University (2005), Biological Sciences

Graduate School

Michigan State University (2007), Statistics

Research Fellowship

University of Michigan Medical Center (2010), Dermatology

Research Fellowship

University of Michigan Medical Center (2010), Pathology

Research Fellowship

Harvard Medical School (2012), Genetics

Medical School

Ohio University Heritage College of Osteopathic Medicine (2019)

Residency

The Jewish Hospital Mercy Health (2022), Internal Medicine

• Bioinformatics
• Health Data Analytics
• Inflammatory Mechanisms of Aging and Disease

Featured Publications

Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs.

Swindell WR, Bojanowski K, Singh P, Randhawa M, Chaudhuri RK, JID Innov 2023 May 3 3 100178

Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin.

Wiedemann J, Billi AC, Bocci F, Kashgari G, Xing E, Tsoi LC, Meller L, Swindell WR, Wasikowski R, Xing X, Ma F, Gharaee-Kermani M, Kahlenberg JM, Harms PW, Maverakis E, Nie Q, Gudjonsson JE, Andersen B, Cell Rep 2023 Jan 42 1 111994

Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis.

Swindell WR, Bojanowski K, Chaudhuri RK, Int J Mol Sci 2022 Nov 23 22

Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta-analysis.

Parish AJ, Swindell WR, Aging Cell 2022 Oct e13733

Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes.

Swindell WR, Bojanowski K, Chaudhuri RK, Pharmaceuticals (Basel) 2022 Apr 15 4

Large-scale analysis of longitudinal skin gene expression in systemic sclerosis reveals relationships of immune cell and fibroblast activity with skin thickness and a trend towards normalisation over time.

Skaug B, Lyons MA, Swindell WR, Salazar GA, Wu M, Tran TM, Charles J, Vershel CP, Mayes MD, Assassi S, Ann Rheum Dis 2022 04 81 4 516-523

Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.

Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL, Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE, Hegazy M, Amagai S, Harms PW, Xing X, Kirma J, Johnson JL, Urciuoli G, Doglio LT, Swindell WR, Awatramani R, Sprecher E, Bao X, Cohen-Barak E, Missero C, Gudjonsson JE, Green KJ, J Clin Invest 2022 02 132 3

A Sensitization-Free Dimethyl Fumarate Prodrug, Isosorbide Di-(Methyl Fumarate), Provides a Topical Treatment Candidate for Psoriasis.

Bojanowski K, Ibeji CU, Singh P, Swindell WR, Chaudhuri RK, JID Innov 2021 Dec 1 4 100040

Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris.

Shao S, Chen J, Swindell WR, Tsoi LC, Xing X, Ma F, Uppala R, Sarkar MK, Plazyo O, Billi AC, Wasikowski R, Smith KM, Honore P, Scott VE, Maverakis E, Kahlenberg JM, Wang G, Ward NL, Harms PW, Gudjonsson JE, JCI Insight 2021 10 6 20

IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.

Shao S, Tsoi LC, Swindell WR, Chen J, Uppala R, Billi AC, Xing X, Zeng C, Sarkar MK, Wasikowski R, Jiang Y, Kirma J, Sun J, Plazyo O, Wang G, Harms PW, Voorhees JJ, Ward NL, Ma F, Pellegrini M, Merleev A, Perez White BE, Modlin RL, Andersen B, Maverakis E, Weidinger S, Kahlenberg JM, Gudjonsson JE, J Invest Dermatol 2021 10 141 10 2436-2448

• Research Scholar Award
  American Skin Association (2013)
• Distinguished Dissertation Award
  Bowling Green State University (2006)
• Dissertation Improvement Grant
  National Science Foundation (2005)

• American College of Physicians
• Texas Medical Association