William Swindell, D.O., Ph.D.

Download Curriculum Vitae

William Swindell, D.O., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Hospital Medicine Division. His clinical interests include general internal medicine, geriatric medicine, and endocrinology.

Originally from Cleveland, Ohio, Dr. Swindell holds a bachelor's degree and a doctorate in biology from Bowling Green State University in Bowling Green, Ohio, and a master's degree in statistics from Michigan State University in East Lansing, Michigan. He completed postdoctoral research studies at the University of Michigan in Ann Arbor, Michigan, Brigham & Women's Hospital in Boston, Massachusetts, and at Harvard Medical School. He received his medical degree from the Ohio University Heritage College of Osteopathic Medicine in Athens, Ohio, and then completed internal medicine residency training at The Jewish Hospital — Mercy Health in Cincinnati, Ohio.

Dr. Swindell's research interests include bioinformatics and health data analytics, inflammatory mechanisms of aging and disease, and amyotrophic lateral sclerosis. His investigations have resulted in more than 100 publications in peer-reviewed journals, and his findings have been presented at scientific conferences throughout the U.S. and around the world. 

Dr. Swindell is active in professional societies such as the American College of Physicians and Texas Medical Association.

Outside of medicine, Dr. Swindell enjoys traveling, exercising, sports, and spending time with family.

Graduate School

Bowling Green State University (2005), Biological Sciences

Graduate School

Michigan State University (2007), Statistics

Research Fellowship

University of Michigan Medical Center (2010), Dermatology

Research Fellowship

University of Michigan Medical Center (2010), Pathology

Research Fellowship

Harvard Medical School (2012), Genetics

Medical School

Ohio University Heritage College of Osteopathic Medicine (2019)

Residency

The Jewish Hospital Mercy Health (2022), Internal Medicine

• Amyotrophic lateral sclerosis
• Bioinformatics and health data analytics
• Inflammatory mechanisms of aging and disease

Featured Publications

Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.

Jiang Y, Gruszka D, Zeng C, Swindell WR, Gaskill C, Sorensen C, Brown W, Gangwar RS, Tsoi LC, Webster J, Sigurdardottir SL, Sarkar MK, Uppala R, Kidder A, Xing X, Plazyo O, Xing E, Billi AC, Maverakis E, Kahlenberg JM, Gudjonsson J, Ward NL, JCI Insight 2024 Mar

HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.

Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, iScience 2024 Feb 27 2 108986

A Critical Role for IFN-β Signaling for IFN-κ Induction in Keratinocytes

Xu B, Musai J, Tan YS, Hile GA, Swindell WR, Klein B, Qin JT, Sarkar MK, Gudjonsson JE, Kahlenberg JM Frontiers in Lupus 2024 2 1359714

FPR1 contributes to epidermal barrier dysfunction-induced skin inflammation through NLRC4-dependent keratinocyte activation.

Shao S, Sun Z, Chu M, Chen J, Cao T, Swindell WR, Bai Y, Li Q, Ma J, Zhu Z, Schuler A, Helfrich Y, Billi AC, Li Z, Hao J, Xiao C, Dang E, Gudjonsson JE, Wang G, Br J Dermatol 2023 Nov

Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs.

Swindell WR, Bojanowski K, Singh P, Randhawa M, Chaudhuri RK, JID Innov 2023 May 3 3 100178

Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging.

Meyer TA, Swindell WR, Chaudhuri RK, Antioxidants (Basel) 2023 May 12 6

Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin.

Wiedemann J, Billi AC, Bocci F, Kashgari G, Xing E, Tsoi LC, Meller L, Swindell WR, Wasikowski R, Xing X, Ma F, Gharaee-Kermani M, Kahlenberg JM, Harms PW, Maverakis E, Nie Q, Gudjonsson JE, Andersen B, Cell Rep 2023 Jan 42 1 111994

Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis.

Swindell WR, Bojanowski K, Chaudhuri RK, Int J Mol Sci 2022 Nov 23 22

Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta-analysis.

Parish AJ, Swindell WR, Aging Cell 2022 Oct e13733

Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes.

Swindell WR, Bojanowski K, Chaudhuri RK, Pharmaceuticals (Basel) 2022 Apr 15 4

• Research Scholar Award
  American Skin Association (2013)
• Distinguished Dissertation Award
  Bowling Green State University (2006)
• Dissertation Improvement Grant
  National Science Foundation (2005)

• American College of Physicians
• Texas Medical Association