William Swindell, D.O., Ph.D. Assistant Professor School Medical School Department Internal Medicine You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Download Curriculum Vitae William Swindell, D.O., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Hospital Medicine Division. His clinical interests include general internal medicine, geriatric medicine, and endocrinology. Originally from Cleveland, Ohio, Dr. Swindell holds a bachelor's degree and a doctorate in biology from Bowling Green State University in Bowling Green, Ohio, and a master's degree in statistics from Michigan State University in East Lansing, Michigan. He completed postdoctoral research studies at the University of Michigan in Ann Arbor, Michigan, Brigham & Women's Hospital in Boston, Massachusetts, and at Harvard Medical School. He received his medical degree from the Ohio University Heritage College of Osteopathic Medicine in Athens, Ohio, and then completed internal medicine residency training at The Jewish Hospital — Mercy Health in Cincinnati, Ohio. Dr. Swindell's research interests include bioinformatics and health data analytics, inflammatory mechanisms of aging and disease, and amyotrophic lateral sclerosis. His investigations have resulted in more than 100 publications in peer-reviewed journals, and his findings have been presented at scientific conferences throughout the U.S. and around the world. Dr. Swindell is active in professional societies such as the American College of Physicians and Texas Medical Association. Outside of medicine, Dr. Swindell enjoys traveling, exercising, sports, and spending time with family. Education Other Post Graduate Training Bowling Green State University (2005) Graduate School Bowling Green State University (2005), Biological Sciences Other Post Graduate Training Michigan State University (2007) Graduate School Michigan State University (2007), Statistics Research Fellowship University of Michigan Medical Center (2010), Dermatology Research Fellowship University of Michigan Medical Center (2010), Pathology Research Fellowship Harvard Medical School (2012), Genetics Medical School Ohio University Heritage College of Osteopathic Medicine (2019) Residency The Jewish Hospital Mercy Health (2022), Internal Medicine Research Interest Amyotrophic lateral sclerosis Bioinformatics and health data analytics Inflammatory mechanisms of aging and disease Publications Featured Publications Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling. Jiang Y, Gruszka D, Zeng C, Swindell WR, Gaskill C, Sorensen C, Brown W, Gangwar RS, Tsoi LC, Webster J, Sigurdardottir SL, Sarkar MK, Uppala R, Kidder A, Xing X, Plazyo O, Xing E, Billi AC, Maverakis E, Kahlenberg JM, Gudjonsson J, Ward NL, JCI Insight 2024 Mar HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling. Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, iScience 2024 Feb 27 2 108986 A Critical Role for IFN-β Signaling for IFN-κ Induction in Keratinocytes Xu B, Musai J, Tan YS, Hile GA, Swindell WR, Klein B, Qin JT, Sarkar MK, Gudjonsson JE, Kahlenberg JM Frontiers in Lupus 2024 2 1359714 Meta-analysis of differential gene expression in lower motor neurons isolated by laser capture microdissection from post-mortem ALS spinal cords. Swindell WR, Front Genet 2024 15 1385114 FPR1 contributes to epidermal barrier dysfunction-induced skin inflammation through NLRC4-dependent keratinocyte activation. Shao S, Sun Z, Chu M, Chen J, Cao T, Swindell WR, Bai Y, Li Q, Ma J, Zhu Z, Schuler A, Helfrich Y, Billi AC, Li Z, Hao J, Xiao C, Dang E, Gudjonsson JE, Wang G, Br J Dermatol 2023 Nov Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs. Swindell WR, Bojanowski K, Singh P, Randhawa M, Chaudhuri RK, JID Innov 2023 May 3 3 100178 Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging. Meyer TA, Swindell WR, Chaudhuri RK, Antioxidants (Basel) 2023 May 12 6 Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin. Wiedemann J, Billi AC, Bocci F, Kashgari G, Xing E, Tsoi LC, Meller L, Swindell WR, Wasikowski R, Xing X, Ma F, Gharaee-Kermani M, Kahlenberg JM, Harms PW, Maverakis E, Nie Q, Gudjonsson JE, Andersen B, Cell Rep 2023 Jan 42 1 111994 Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis. Swindell WR, Bojanowski K, Chaudhuri RK, Int J Mol Sci 2022 Nov 23 22 Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta-analysis. Parish AJ, Swindell WR, Aging Cell 2022 Oct e13733 Results 1-10 of 104 1 2 3 4 5 Next Last Honors & Awards Research Scholar AwardAmerican Skin Association (2013) Distinguished Dissertation AwardBowling Green State University (2006) Dissertation Improvement GrantNational Science Foundation (2005) Professional Associations/Affiliations American College of Physicians Texas Medical Association
