Xiao-Fei Kong, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Digestive & Liver Diseases.

Originally from China, Dr. Kong earned his medical degree at Yangzhou University Medical College in Jiangsu, China, and completed a residency in internal medicine at Ruijin Hospital at Shanghai Jiaotong University. He then earned a doctoral degree in immunology and genetics from the Sorbonne University in Paris, France. He later earned a master's degree in translational medicine from the Rockefeller University in New York. He received additional internal medicine residency training at the Icahn School of Medicine at Mount Sinai, followed by advanced training through a fellowship in gastroenterology.

Certified by the American Board of Internal Medicine in internal medicine and gastroenterology, he joined the UT Southwestern faculty in 2022.

Dr. Kong's research interests include celiac disease, inflammatory bowel disease, inborn errors of immunity, and rare liver diseases. His previous work led to the discovery of serval new genetic diseases, including human SPPL2A deficiency, inherited STAT1 disorders and interferonopathy in Down Syndrome. He has published numerous articles in peer-reviewed journals and presented widely at national and international conferences.

Dr. Kong is an active member of several professional organizations, including the American Association for the Study of Liver Diseases, the American Gastroenterological Association, and the European Society for Immunodeficiencies.


Medical School
Yangzhou University Medical College (2001)
Other Post Graduate Training
The Rockefeller University (2015)
Icahn School of Medicine at Mount Sinai /Queens Hospital Center (2018), Internal Medicine
New York Presbyterian Hospital - Columbia Campus (2021), Gastroenterology

Research Interest

  • Celiac Disease
  • Human Genetics
  • Immunology
  • Inflammatory Bowel Disease
  • Rare Digestive & Liver Diseases


Featured Publications LegendFeatured Publications

Immunogenetics of gastrointestinal cancers: A systematic review and retrospective survey of inborn errors of immunity in humans.
Zheng B, Artin MG, Chung H, Chen B, Sun S, May BL, Hur C, Green PHR, Wang TC, Park J, Kong XF, J Gastroenterol Hepatol 2022 Jun 37 6 973-982
Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.
Malle L, Gao C, Hur C, Truong HQ, Bouvier NM, Percha B, Kong XF, Bogunovic D, Genet Med 2021 03 23 3 576-580

Honors & Awards

  • Clinical and Translational Science Award
    The Rockefeller University (2015)
  • Jérôme Lejeune Foundation Award
  • Stony Wold-Herbert Fund Award
  • C.H. Li Memorial Scholar Award
  • Keystone Symposia Travel Award
  • First-Prize Scholarship,
    Shanghai Jiaotong University, School of Medicine (2004)

Professional Associations/Affiliations

  • American Association for the Study of Liver Diseases
  • American Gastroenterological Association
  • Clinical Immunology Society (2010)
  • European Society for Immunodeficiencies (2012)