Abd El Kareem Azab, Ph.D. Associate Professor School Medical School Department Biomedical Engineering Graduate Programs Biomedical Engineering, Cancer Biology Biography Download Curriculum Vitae Dr. Kareem Azab, PhD, is an Associate Professor of Biomedical Engineering, Rising Star CPRIT Scholar of Cancer Research, and a Senior Member of The National Academy of Inventors. Dr. Azab is also a founder of four spinoff startup companies: Cellatrix LLC, Targeted Therapeutics LLC, OncInsights LLC, and CovACE Nanotechnology LLC. Dr. Azab completed his Pharmacy studies, M.Sc. (in Medicinal Chemistry), and Ph.D. (in Pharmaceutical Sciences) at the Hebrew University of Jerusalem, and a post-doctoral training (in Cancer Biology and Immunology) at Dana-Farber Cancer Institute, Harvard University. The research in Dr. Azab’s multidisciplinary (including biomedical engineering, cancer biology and immunology, pharmaceutical sciences, and medicinal chemistry), aiming to translate the laboratory findings into patient care through clinical trials and entrepreneurial approaches. Specifically, it focuses on development of novel cancer therapeutics, mainly through discovery of cancer-specific biomarkers and mechanisms which involve the effect of tumor microenvironment (TME) in drug resistance and metastasis, as well as development of novel solutions for cancer immunotherapy, tissue engineered cancer models ex vivo for drug development and personalized medicine, and an array of drug delivery systems including lipid and polymeric nanoparticles for systemic delivery, and drug eluting biodegradable implants for local therapy, for improved efficacy and reduced toxicity of cancer therapy. Dr. Azab’s current and future research focuses on development of novel pan-cancer immunotherapeutic strategies, over-coming TME-induced drug resistance, nanoparticles for cancer theranostics, biodegradable drug eluting implants for localized tumor control, and tissue engineered ex-vivo models for personalized cancer therapy. Research Interest 3D Tissue Cultures Biodegradable Implants BNCT Drug Delivery Systems Drug Development Drug Resistance Immunotherapy Multiple Myeloma Nanoparticles Personalized Medicine Tissue Engineering Tumor Hypoxia Tumor Metastasis Tumor Microenvironment Publications Featured Publications A pilot study of 3D tissue-engineered bone marrow culture as a tool to predict patient response to therapy in multiple myeloma. Alhallak K, Jeske A, de la Puente P, Sun J, Fiala M, Azab F, Muz B, Sahin I, Vij R, DiPersio JF, Azab AK, Sci Rep 2021 09 11 1 19343 Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy. Alhallak K, Sun J, Wasden K, Guenthner N, O'Neal J, Muz B, King J, Kohnen D, Vij R, Achilefu S, DiPersio JF, Azab AK, Leukemia 2021 08 35 8 2346-2357 Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma. Federico C, Alhallak K, Sun J, Duncan K, Azab F, Sudlow GP, de la Puente P, Muz B, Kapoor V, Zhang L, Yuan F, Markovic M, Kotsybar J, Wasden K, Guenthner N, Gurley S, King J, Kohnen D, Salama NN, Thotala D, Hallahan DE, Vij R, DiPersio JF, Achilefu S, Azab AK, Nat Commun 2020 11 11 1 6037 Targeting CD47 as a Novel Immunotherapy for Multiple Myeloma. Sun J, Muz B, Alhallak K, Markovic M, Gurley S, Wang Z, Guenthner N, Wasden K, Fiala M, King J, Kohnen D, Salama NN, Vij R, Azab AK, Cancers (Basel) 2020 Jan 12 2 Thermal Sensitive Liposomes Improve Delivery of Boronated Agents for Boron Neutron Capture Therapy. Luderer MJ, Muz B, Alhallak K, Sun J, Wasden K, Guenthner N, de la Puente P, Federico C, Azab AK, Pharm Res 2019 Aug 36 10 144 Enhancing proteasome-inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma. de la Puente P, Luderer MJ, Federico C, Jin A, Gilson RC, Egbulefu C, Alhallak K, Shah S, Muz B, Sun J, King J, Kohnen D, Salama NN, Achilefu S, Vij R, Azab AK, J Control Release 2018 01 270 158-176 A Hypoxia-Targeted Boron Neutron Capture Therapy Agent for the Treatment of Glioma. Luderer MJ, Muz B, de la Puente P, Chavalmane S, Kapoor V, Marcelo R, Biswas P, Thotala D, Rogers B, Azab AK, Pharm Res 2016 10 33 10 2530-9 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma. de la Puente P, Muz B, Gilson RC, Azab F, Luderer M, King J, Achilefu S, Vij R, Azab AK, Biomaterials 2015 Dec 73 70-84 The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Muz B, de la Puente P, Azab F, Azab AK, Hypoxia (Auckl) 2015 3 83-92 Hypoxia promotes stem cell-like phenotype in multiple myeloma cells. Muz B, de la Puente P, Azab F, Luderer M, Azab AK, Blood Cancer J 2014 Dec 4 e262 Results 1-10 of 97 1 2 3 4 5 Next Last Books Featured Books Biomaterials for Cancer Immunotherapy. In Biomaterials for cancer therapeutics: Evolution and Innovation Alhallak K, Sun J, Muz B, and Azab AK (2020). Amsterdam, Elsevier Boron neutron capture therapy. In Contemporary Aspects of Boron: Chemistry and Biological Applications Azab AK, Abu Ali H and Srebnik M (2005). Amsterdam, Elsevier Honors & Awards National Academy of InventorsSenior Member (2023-2023) CPRIT Rising Star AwardCancer Prevention and Research Institute of Texas, Dallas, TX (2022-2027) WashU Inventor Award Office of Technology Management, Washington University in St. LouisOffice of Technology Management, Washington University in St. Louis (2020-2020) WashU Inventor AwardOffice of Technology Management, Washington University in St. Louis (2019-2019) LEAP Leadership in Entrepreneurial Acceleration ProgramSkandalaris Center, Washington University in Saint Louis. (2017-2017) WashU Inventor AwardOffice of Technology Management, Washington University in St. Louis (2017-2017) Bear Cub Competition for Innovation and EntrepreneurshipSkandalaris Center, Washington University in Saint Louis. (2016-2016) i6 SparkBiogenerator-BioSTL, Saint Louis, MO. (2016-2016) Bear Cub Competition for Innovation and EntrepreneurshipSkandalaris Center, Washington University in Saint Louis. (2015-2015) Abstract Achievement AwardAnnual Meeting of the American Society of Hematology, San Diego, California, USA. (2011-2011) AACR-Amgen, Inc. Fellowship in Clinical/Translational Cancer ResearchAmerican Association of Cancer Research, Washington DC, USA. (2010-2010) Young Investigator Award6th International Workshop on Waldenstrom's Macroglobulinemia, Venice, Italy (2010-2010) Merit AwardAmerican Society of Clinical Oncology Annual Meeting, Orlando, Florida, USA (2009-2009) Travel AwardAnnual Meeting of the American Society of Hematology, San Diego, California, USA. (2009-2009) Fellow AwardMultiple Myeloma Research Foundation, Norwalk, Connecticut, USA. (2008-2009) Travel AwardAnnual Meeting of the American Society of Hematology, San Diego, California, USA. (2008-2008) Excellent Research StudentSchool of Pharmacy, The Hebrew University of Jerusalem, Israel. (2006-2006) First Place Poster AwardGordon Research Conference on Drug Carriers in Medicine and Biology, Big Sky, Montana, USA. (2006-2006) ParticipantThe 18th Meeting of Nobel Prize Laureates in Chemistry Lindau, Lake Constance, Germany. (2006-2006) Abraham and Ada Barzilai Award for Outstanding Work Proposal in Cancer ResearchThe Israeli Ministry of Justice & The Hebrew University of Jerusalem, Israel. (2001-2001) Outstanding Teaching AssistantSchool of Pharmacy, The Hebrew University of Jerusalem, Israel. (2001-2005) Professional Associations/Affiliations American Association of Cancer Research (2010) American Association of Pharmaceutical Sciences (2012) American Chemical Society (2015) American Society for Radiation Oncology (2015) American Society of Clinical Oncology (2009) American Society of Hematology, Member (2007) Biomedical Engineering Society (2022) Controlled Release Society, Member (2005) International Myeloma Society (2006) Radiation Research Society (2015)
