Frederick Hitti, M.D., Ph.D., is an Assistant Professor in the Departments of Neurological Surgery and Psychiatry at UT Southwestern Medical Center. He specializes in epilepsy and movement disorders, including Parkinson's disease, essential tremor, and dystonia.

Dr. Hitti earned his medical degree and a doctoral degree in neurobiology and behavior at Columbia University in New York. He completed a residency in neurosurgery and a fellowship in functional neurosurgery at the University of Pennsylvania in Philadelphia. He also completed postdoctoral research at the Children’s Hospital of Philadelphia.

He joined the UT Southwestern faculty in 2022 and is a functional neurosurgeon focused on the development of treatments for neurologic and psychiatric disorders. He is particularly interested in employing gene therapy to ameliorate disease. He has used electrophysiology, mouse transgenesis, viral transduction, optogenetics, chemogenetics, stereotactic surgery, and behavioral assays to probe the circuitry of the mammalian brain. His research efforts are focused on developing novel therapies for treatment resistant depression.


Medical School
Columbia University College of Physicians and Surgeons (2015)
University of Pennsylvania (2022)

Research Interest

  • Deep Brain Stimulation
  • Gene Therapy
  • Lateral Habenula
  • Treatment Resistant Depression


Featured Publications LegendFeatured Publications

Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor Under General Anesthesia: Technical Note.
Mensah-Brown KG, Yang AI, Hitti FL, Henry L, Heman-Ackah SM, Chaibainou H, Baltuch GH, Oper Neurosurg (Hagerstown) 2022 04 22 4 255-260
Feasibility of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor in the Setting of Prior Craniotomy.
Wathen C, Yang AI, Hitti FL, Henry L, Chaibainou H, Baltuch GH, Oper Neurosurg (Hagerstown) 2022 02 22 2 61-65
Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates.
Yang AI, Mensah-Brown KG, Shekhtman EF, Kvint S, Wathen CA, Hitti FL, Alonso-Basanta M, Avery SM, Dorsey JF, Y K Lee J, J Radiosurg SBRT 2022 8 2 117-125
Patient-specific effects on sonication heating efficiency during magnetic resonance-guided focused ultrasound thalamotomy.
Yang AI, Hitti FL, Alabi OO, Joshi D, Chaibainou H, Henry L, Clanton R, Baltuch GH, Med Phys 2021 Nov 48 11 6588-6596
Letter: Lesion Shape and Size in MRgFUS Thalamotomy: Predictors and Implications.
Yang AI, Alabi OO, Hitti FL, Henry L, Clanton R, Baltuch GH, Neurosurgery 2021 08 89 3 E198-E200

Honors & Awards

  • Kavli Award for Distinguished Research in Neuroscience
  • Titus Munson Coan Prize - best essay in biological sciences
  • Graduated summa cum laude
  • Graduated with High Honors
  • Barry M. Goldwater Scholar
  • Best Oral Presentation - Dartmouth Neuroscience Day
  • Dartmouth College Presidential Scholarship
  • Phi Beta Kappa Honor Society, Dartmouth College
  • Andrew Warden Edson Memorial Prize in Government
  • Faculty for Undergraduate Neuroscience Travel Award
  • Francis L. Town Scientific Prize in Biology

Professional Associations/Affiliations

  • American Association of Neurological Surgeons (2015)
  • Congress of Neurological Surgeons (2015)