Danielle Callaway, M.D., Ph.D. Assistant Professor School Medical School Department Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Dr. Danielle Callaway is a native of Texas who grew up in San Antonio and attended the University of Texas at Dallas for her bachelor's degree. She then received her M.D., Ph.D. at University of Texas Health San Antonio where she became enamored with redox biology and neonatal physiology. For Pediatrics Residency, she attended Baylor College of Medicine and participated in the Pediatrician Scientist Training Program there, working alongside Dr. Bhagavatula Moorthy for her residency research project where she studied the effects of hyperoxia on cytochrome P4501A genes in a mouse lacking Nrf2. Fellowship in Neonatal-Perinatal Medicine uprooted her to the Children's Hospital of Philadelphia where she also did her postdoctoral studies in the laboratory of Dr. Edward Morrisey, a driving force for high impact studies in lung development and regeneration. As a part of her work in Dr. Morrisey's lab, Dr. Callaway sought to further describe the importance of the type 1 pulmonary epithelial (AT1) cell to neonatal life beyond the role of a simple unit for gas exchange. This work has formed the basis for the founding of her independent laboratory and resulted in a K08 Award from the NIH. As an Assistant Professor in the Department of Pediatrics at the University of Texas Southwestern Medical Center, her lab focuses on the effects of mechanical force on AT1 cells both prenatally and postnatally to drive changes in gene transcription, extracellular matrix remodeling, and intercellular communication across the developing lung. To accomplish this, the lab will utilize specialized transgenic and surgical mouse models, cutting-edge imaging techniques, and next-gen sequencing all with the goal of making life better for babies. Education Other Post Graduate Training University of Texas Health Science Center at San Antonio (2014) Medical School University of Texas Health Science Center at San Antonio (2016) Residency Baylor College of Medicine/Texas Children's Hospital (2019), Pediatrics Fellowship Children's Hospital of Philadelphia (2022), Neonatal-perinatal Medicine Research Interest Lung developmental biology, bronchopulmonary dysplasia Publications Featured Publications TGF-β controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription in mice. Callaway DA, Penkala IJ, Zhou S, Knowlton JJ, Cardenas-Diaz F, Babu A, Morley MP, Lopes M, Garcia BA, Morrisey EE, J Clin Invest 2024 Jan 134 6 Lung biopsy in infants with severe bronchopulmonary dysplasia. Callaway DA, Wang Y, Lingappan K, Pogoriler JE, Laje P, Nilan K, Kirpalani H, Zhang H, Pediatr Pulmonol 2023 Jul 58 7 2068-2075 Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1. Cardenas-Diaz FL, Liberti DC, Leach JP, Babu A, Barasch J, Shen T, Diaz-Miranda MA, Zhou S, Ying Y, Callaway DA, Morley MP, Morrisey EE, Cell Rep 2023 May 42 5 112451 Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B, Free Radic Biol Med 2020 Nov 160 208-218 Prioritization of Candidate Genes for Congenital Diaphragmatic Hernia in a Critical Region on Chromosome 4p16 using a Machine-Learning Algorithm. Callaway DA, Campbell IM, Stover SR, Hernandez-Garcia A, Jhangiani SN, Punetha J, Paine IS, Posey JE, Muzny D, Lally KP, Lupski JR, Shaw CA, Fernandes CJ, Scott DA, J Pediatr Genet 2018 Dec 7 4 164-173 Prematurity disrupts glomeruli development, whereas prematurity and hyperglycemia lead to altered nephron maturation and increased oxidative stress in newborn baboons. Callaway DA, McGill-Vargas LL, Quinn A, Jordan JL, Winter LA, Anzueto D, Dick EJ, Blanco CL, Pediatr Res 2018 Mar 83 3 702-711 Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Callaway DA, Riquelme MA, Sharma R, Lopez-Cruzan M, Herman BA, Jiang JX, Bone 2016 Dec 93 233-234 Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases. Callaway DA, Jiang JX, J Bone Miner Metab 2015 Jul 33 4 359-70 A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B, Autophagy 2014 Jun 10 6 1054-70 Connexin43 hemichannels mediate small molecule exchange between chondrocytes and matrix in biomechanically-stimulated temporomandibular joint cartilage. Zhang J, Zhang HY, Zhang M, Qiu ZY, Wu YP, Callaway DA, Jiang JX, Lu L, Jing L, Yang T, Wang MQ, Osteoarthritis Cartilage 2014 Jun 22 6 822-30 Results 1-10 of 10 1 Honors & Awards Children's Hospital of Philadelphia Abbasi-Gerdes Junior Faculty Development Award (2023) Parker B. Francis Fellowship Award (2023) Perinatal Research Society NIH-Reckitt/Mead Johnson Nutrition Young Investigator Workshop Acceptance (2022) Children's Hospital of Philadelphia Neonatal-Perinatal Medicine Fellows Research Award (2021) American Academy of Pediatrics Marshall Klaus Award (2020) Society for Pediatric Research House Officer Research Award (2019) Greehey MD, PhD Scholar Award, University of Texas Health San Antonio (2015) David Carillo Memorial Fellowship Award, University of Texas Health San Antonio (2012) Professional Associations/Affiliations American Academy of Pediatrics (2016) American Thoracic Society, Member (2019) Bronchopulmonary Dysplasia Collaborative, Translation Medicine Subgroup (2024) National Pediatrician Scientist Collaborative Workgroup (2022) Perinatal Research Society, Associate Member (2022) Society for Pediatric Research, Member (2020)
