
Marek Napierala, Ph.D.
Associate Professor
Department Neurology | Peter O’Donnell Jr. Brain Institute
Biography
M.S. In Biotechnology, Adam Michiewicz University, Posnan, Poland (1995)
Ph.D. in Biochemistry, Institute of Bioorganic Chemistry, Polish Academy of Schiences, Pozman, Poland (1999)
Education
- Graduate School
- Adam Mickiewicz University (1995), Biotechnology
- Graduate School
- Polish Acad of Science Institu (1999), Biochemistry
Publications
Featured Publications
- Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.
- Li Y, Li J, Wang J, Lynch DR, Shen X, Corey DR, Parekh D, Bhat B, Woo C, Cherry JJ, Napierala JS, Napierala M, Nucleic Acids Res 2021 11 49 20 11560-11574
- Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia.
- Napierala JS, Rajapakshe K, Clark A, Chen YY, Huang S, Mesaros C, Xu P, Blair IA, Hauser LA, Farmer J, Lynch DR, Edwards DP, Coarfa C, Napierala M, Mol Cell Proteomics 2021 20 100094
- Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.
- Li J, Li Y, Wang J, Gonzalez TJ, Asokan A, Napierala JS, Napierala M, Hum Gene Ther 2020 08 31 15-16 839-851
- Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.
- Fil D, Chacko BK, Conley R, Ouyang X, Zhang J, Darley-Usmar VM, Zuberi AR, Lutz CM, Napierala M, Napierala JS, Dis Model Mech 2020 07 13 7
- Excision of the expanded GAA repeats corrects cardiomyopathy phenotypes of iPSC-derived Friedreich's ataxia cardiomyocytes.
- Li J, Rozwadowska N, Clark A, Fil D, Napierala JS, Napierala M, Stem Cell Res 2019 10 40 101529
- Therapeutic Prospects for Friedreich's Ataxia.
- Zhang S, Napierala M, Napierala JS, Trends Pharmacol Sci 2019 04 40 4 229-233
- Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.
- Gerhardt J, Bhalla AD, Butler JS, Puckett JW, Dervan PB, Rosenwaks Z, Napierala M, Cell Rep 2016 08 16 5 1218-1227
- Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.
- Li Y, Lu Y, Polak U, Lin K, Shen J, Farmer J, Seyer L, Bhalla AD, Rozwadowska N, Lynch DR, Butler JS, Napierala M, Hum Mol Genet 2015 Dec 24 24 6932-43
- Cellular pathophysiology of Friedreich's ataxia cardiomyopathy.
- Lees JG, Napierala M, Pébay A, Dottori M, Lim SY, Int J Cardiol 2022 Jan 346 71-78
- Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice.
- Kilikevicius A, Wang J, Shen X, Rigo F, Prakash TP, Napierala M, Corey DR, RNA Biol 2022 Jan 19 1 364-372
Professional Associations/Affiliations
- Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland (1995-1999)
- University of Adam Mickiewicz, Poznan, Poland (1990-1995)