Tuoqi Wu, Ph.D.

Education
2007-2013 - Ph.D., Emory University, Atlanta, GA. Thesis Advisor: Rafi Ahmed

2003-2007 - B.S. in Biotechnology, Dual B.S. in Computer Science, Peking University, Beijing, China

Positions
2021-present - Assistant Professor, Department of Immunology, UT Southwestern Medical Center, Dallas, TX

2019-2021 - Assistant professor, Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO

2013-2019 - Visiting fellow, National Institutes of Health, Bethesda, MD

2008-2013 - Graduate research assistant, Emory University, Atlanta, GA

2006-2007 - Undergraduate researcher, National Institute of Biomedical Sciences, Beijing, China

• cancer immunotherapy
• immunosenescence
• T cell exhaustion
• T cell stemness

Featured Publications

FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells.

Zhu Z, Lou G, Teng XL, Wang H, Luo Y, Shi W, Yihunie K, Hao S, DeGolier K, Liao C, Huang H, Zhang Q, Fry T, Wang T, Yao C, Wu T, Nat Immunol 2023 Nov

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells.

Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T, Nat Immunol 2021 Mar 22 3 370-380

Single-cell RNA-seq reveals TOX as a key regulator of CD8⁺ T cell persistence in chronic infection.

Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T, Nat. Immunol. 2019 07 20 7 890-901

The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL Sci Immunol 2016 Dec 1 6

TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.

Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL, Cell Rep 2015 Sep 12 12 2099-110

Facts and hopes for immunotherapy in renal cell carcinoma.

Yao C, Zhang T, Wu T, Brugarolas J, Clin Cancer Res 2022 Jul

IL-27 promotes the expansion of self-renewing CD8⁺ T cells in persistent viral infection.

Huang Z, Zak J, Pratumchai I, Shaabani N, Vartabedian VF, Nguyen N, Wu T, Xiao C, Teijaro JR, J Exp Med 2019 08 216 8 1791-1808

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8⁺ T cell fate.

Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, Lacey NE, Gautam S, Le Gall JB, Yang X, Hocker JD, Escobar TM, He S, Dell'Orso S, Hawk NV, Kapoor V, Telford WG, Di Croce L, Muljo SA, Zhang Y, Sartorelli V, Gattinoni L, Nat Commun 2019 05 10 1 2157

mTOR promotes anti-viral humoral immunity by differentially regulating CD4 helper T cell and B cell responses.

Ye L, Lee J, Xu L, Mohammed AU, Li W, Hale JS, Tan WG, Wu T, Davis CW, Ahmed R, Araki K J. Virol. 2016 Dec

Type I interferon suppresses virus-specific B cell responses by modulating CD8⁺ T cell differentiation.

Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB, Sci Immunol 2016 Oct 1 4

• ASPIRE Award for Outstanding Early Career Investigators (The American Association of Immunologists, AAI)
  (2023-2023)
• AAI Early Career Faculty Travel Grant
  (2021)
• AFAR Grants for Junior Faculty
  (2021-2023)
• V Scholar Award
  (2020-2022)
• The 19th Annual Norman P. Salzman Memorial Award in Virology
  (2017-2017)