Amanda Clark, M.D. - Faculty Profile

Biography

Amanda Clark, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center. Her research focuses on how maternal and fetal metabolism affects fetal kidney development.

Dr. Clark earned her medical degree at the Albert Einstein College of Medicine in the Bronx. She completed a residency in pediatrics at the Monroe Carrell Jr. Children’s Hospital at Vanderbilt University and received advanced training through a pediatric nephrology fellowship at Boston Children’s Hospital and Children’s Medical Center Dallas. Dr. Clark was also a postdoctoral researcher in the Samir Parikh Lab at Beth Israel Deaconess Medical Center at Harvard University and UT Southwestern.

She joined the UT Southwestern faculty in 2024.

Dr. Clark has served as Principal Investigator on research projects funded by the National Institutes of Health, the American Society of Nephrology, and the Pediatric Physician Scientist Development Program. She has delivered international and national invited lectures and published peer-reviewed academic articles related to her areas of expertise.

Dr. Clark is a member of the American Society of Nephrology, the American Society of Pediatric Nephrology, and the International Society of Nephrology.

Education

Medical School: Albert Einstein College of Medicine of Yeshiva University (2015)
Residency: Vanderbilt University Medical Center/Monroe Carell Jr. Children's Hospital (2018), Pediatrics
Fellowship: Boston Children's Hospital/Boston Medical Center (2021), Pediatric Nephrology
Fellowship: UT Southwestern Medical Center/Children's Medical Center (2024), Pediatric Nephrology

Publications

Therapeutic remodeling of the ceramide backbone prevents kidney injury: Nicholson RJ, Cedeño-Rosario L, Maschek JA, Lonergan T, Van Vranken JG, Kruse AR, Stubben CJ, Wang L, Stuart D, Alcantara QA, Revelo MP, Rutter K, Pahulu M, Taloa J, Wu X, Kim J, Kim J, Hall I, Clark AJ, Parikh S, Spraggins J, Romero D, Blitzer JT, Gygi SP, Rutter J, Holland WL, Ramkumar N, Summers SA Cell Metabolism 2026 Jan 38 135-156.e10
Acute kidney injury is associated with elevated urinary endotrophin: Clark AJ, Flores BM, Saade MC, Vu KQ, Pence IJ, Zhang N, An Z, Bu D, Scherer PE, Parikh SM American Journal of Physiology - Renal Physiology 2025 Nov 329 F685-F689
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations: Huang H, Wang Y, Zsengeller ZK, Gorham JM, Vemireddy V, Clark AJ, Pan H, Dreyfuss JM, Jotwani V, Shlipak MG, Sarnak MJ, Parikh CR, Thiessen-Philbrook H, Katz R, Waikar SS, Lake NJ, Lek M, Shi W, Puiu D, Hong YS, Seidman JG, Arking DE, Parikh SM Science 2025 Oct 390 164-172
Pediatric acute kidney injury is associated with impairment in nicotinamide adenine dinucleotide (NAD+) metabolism: Clark AJ, Flores BM, Saade MC, Vu KQ, Pence IJ, Berg A, Parikh SM Pediatric Nephrology 2025 Sep 40 2967-2972
NAD⁺ metabolism in acute kidney injury and chronic kidney disease transition: Alhumaidi R, Huang H, Saade MC, Clark AJ, Parikh SM Trends in Molecular Medicine 2025 Jul 31 669-681
Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis: Suzuki T, Loyde E, Chen S, Etzrodt V, Idowu TO, Clark AJ, Saade MC, Flores BM, Lu S, Birrane G, Vemireddy V, Seeliger B, David S, Parikh SM Journal of Clinical Investigation 2025 Apr 135
Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury: Clark AJ, Saade MC, Vemireddy V, Vu KQ, Flores BM, Etzrodt V, Ciampa EJ, Huang H, Takakura A, Zandi-Nejad K, Zsengellér ZK, Parikh SM Kidney international 2023 Dec 104 1150-1163
States of quinolinic acid excess in urine: A systematic review of human studies: Saade MC, Clark AJ, Parikh SM Frontiers in Nutrition 2022 Dec 9
Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury: Zhong J, Yang HC, Shelton EL, Matsusaka T, Clark AJ, Yermalitsky V, Mashhadi Z, May-Zhang LS, Linton MF, Fogo AB, Kirabo A, Davies SS, Kon V JCI Insight 2022 Nov 7
The Significance of NAD+ Biosynthesis Alterations in Acute Kidney Injury: Clark AJ, Saade MC, Parikh SM Seminars in nephrology 2022 May 42