Andrew Wang, M.D.

Andrew Z. Wang, M.D., Professor (Tenure), holds the A. Kenneth Pye Professorship in Cancer Research and is the Vice Chair for Translational Research and Commercialization in the Department of Radiation Oncology.

Dr. Wang earned two Bachelor of Science degrees in Biochemistry and Biology and a Bachelor of Arts degree in Mathematics from Indiana University with highest distinction. He obtained his medical degree from the Harvard-MIT Health Sciences and Technology (HST) program at Harvard Medical School. After an internship in internal medicine at St. Luke’s Roosevelt Hospital in New York, he completed clinical training in radiation oncology in the Harvard Radiation Oncology Program. During residency, he also completed a postdoctoral fellowship  at Massachusetts Institutes of Technology under the mentorship of Dr. Robert Langer. Following residency, Dr. Wang joined the faculty of University of North Carolina as Assistant Professor in the Department of Radiation Oncology in 2009, where he rose to the rank of Tenured Professor. Dr. Wang joined UTSW faculty in 08/2021.

Dr. Wang’s research program is focused on the application of biomedical engineering to cancer research. His group aims to develop novel cancer diagnostics and therapeutics to improve cancer treatment. His work is high impact and highly innovative and has resulted in 38 patents/patent applications  and three biotechnology startup companies. His work has been published in high impact journals such as Nature Nanotechnology, Advanced Materials, and Nature Biotechnology. Because of his research accomplishments, Dr. Wang has been elected as a member of the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows and the American Society for Clinical Investigation (ASCI).

Clinically, Dr. Wang specializes in the treatment of genitourinary and gastrointestinal cancers. He is familiar with different radiation techniques, including IMRT, IGRT, linac-based SRS, SBRT, and intraoperative radiotherapy and interstitial brachytherapy.

Medical School

Harvard Medical School (2004)

Internship

Columbia University/St. Luke's - Roosevelt Hospital Center (2005), Internal Medicine

Residency

Harvard/Brigham and Women's Hospital/Massachusetts General Hospital (2009)

• Application of biomedical engineering to cancer research
• cancer metastasis
• Developing novel cancer diagnostics and therapeutics to improve cancer treatment
• nanomedicine

Featured Publications

In Vivo Bioengineering of Beta Cells with Immune Checkpoint Ligand as a Treatment for Early-Onset Type 1 Diabetes Mellitus.

Au KM, Tisch R, Wang AZ, ACS Nano 2021 Nov

Immune Checkpoint Ligand-Bioengineered Schwann Cells as Antigen-Specific Therapy for Experimental Autoimmune Encephalomyelitis.

Au KM, Tisch R, Wang AZ, Adv Mater 2021 Nov e2107392

Nanoparticle delivery of miR-122 inhibits colorectal cancer liver metastasis.

Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, Rojas JD, Dayton PA, Huang L, Wang AZ, Cancer Res 2021 Nov

Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes.

Au KM, Medik Y, Ke Q, Tisch R, Wang AZ, Adv Mater 2021 Jun 33 25 e2101253

Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy.

Au KM, Park SI, Wang AZ, Sci Adv 2020 Jul 6 27 eaba8564

Phase I/II trial of nano-camptothecin CRLX101 with capecitabine and radiotherapy as neoadjuvant treatment for locally advanced rectal cancer.

Sanoff HK, Moon DH, Moore DT, Boles J, Bui C, Blackstock W, O'Neil BH, Subramaniam S, McRee AJ, Carlson C, Lee MS, Tepper JE, Wang AZ, Nanomedicine 2019 06 18 189-195

A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy.

Mi Y, Smith CC, Yang F, Qi Y, Roche KC, Serody JS, Vincent BG, Wang AZ, Adv Mater 2018 Jun 30 25 e1706098

Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture.

Myung JH, Eblan MJ, Caster JM, Park SJ, Poellmann MJ, Wang K, Tam KA, Miller SM, Shen C, Chen RC, Zhang T, Tepper JE, Chera BS, Wang AZ, Hong S, Clin Cancer Res 2018 06 24 11 2539-2547

Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.

Tian X, Werner ME, Roche KC, Hanson AD, Foote HP, Yu SK, Warner SB, Copp JA, Lara H, Wauthier EL, Caster JM, Herring LE, Zhang L, Tepper JE, Hsu DS, Zhang T, Reid LM, Wang AZ, Nat Biomed Eng 2018 06 2 6 443-452

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.

Min Y, Roche KC, Tian S, Eblan MJ, McKinnon KP, Caster JM, Chai S, Herring LE, Zhang L, Zhang T, DeSimone JM, Tepper JE, Vincent BG, Serody JS, Wang AZ, Nat Nanotechnol 2017 09 12 9 877-882

 Featured Books

Cancer Nanotherapeutics Administered by Non-Conventional Routes. In Nanotheranostics for cancer applications

Roche KC, Medik YB, Rodgers Z, Warner S, Wang AZ (2019). Springer Nature

Nanotechnology Approaches to Improving Cancer Immunotherapy. In Cancer Nanotechnology

Hagan CT 4th, Medik YB, Wang AZ (2018). Elsevier

Cancer nanotechnology in Radiation Oncology. In Precision Radiation Oncology

4. Caster JM, Zhang T, Patel AN, Newman NJ, Wang AZ (2018). Rutgers Press

Local and locally advanced rectal cancer. In Multidisciplinary Management of Gastrointestinal Cancers

O?Neil BH, Fajardo AD, Wang AZ, Shahda S (2018). World Scientific

Definitions of Biochemical Failure. In Prostate Cancer: A Comprehensive Perspective.

Zhang T, Wang AZ. (2013). Springer

Radioisotopes and Nanomedicine. In Radioisotopes: Application in Bio-medical Science

Sheets NC, Wang AZ. (2011). InTech

Nanoparticles for Cancer Diagnosis and Therapy. In Safety of Nanoparticles: From manufacturing to medical applications

Wang AZ, Gu FX, Farokhzad OC (2009). Springer

Biologically Targeted Nanoparticles as Cancer Therapeutics. In Bio-inspired Nanotechnology and Nanomaterials

Wang AZ, Radovic-Moreno AF, Farokhzad OC (2009). Nova Science Publishers

Underground Clinical Vignettes USMLE Step 2: Surgery. (4th Edition).

Kim, S.I., Swanson, T.A., Wang, AZ (Ed.) (2007). Lippincott Williams & Wilkins/Wolters Kluwer Health

• America's Top Doctors by Castle Connolly
  (2020)
• Elected Member of the American Society for Clinical Investigation (ASCI)
  (2020)
• American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
  (2019)
• ASCO Leadership Development Program
  (2019)
• Associate Scientific Advisor, Science Translational Medicine
  (2016-2016)
• UNC Health Care and Faculty Physicians Award for Carolina Care Excellence
  (2016-2021)
• ASTRO Biology Basic Science Research Abstract Award
  
• ASTRO Junior Faculty Basic Science Research Abstract Award
  
• Betty and Doris Barrett Scholarship, Harvard Medical School
  
• Howard Hughes Medical Institute Research Fellowship for Medical Students
  

• American Association for Cancer Research (AACR) (2007)
• American Society for Radiation Oncology (ASTRO) (2006)
• American Society of Clinical Oncology (ASCO) (2009)
• Associate Editor, BMC Cancer (2018)
• Journal of the National Cancer Institute, Member, Editorial Board (2017)
• Nanomedicine: Nanotechnology, Biology, and Medicine, Associate Editor (2015)
• The American Institute for Medical and Biological Engineering (AIMBE) (2019)
• The American Society for Clinical Investigation (2020)