Chen Yao, Ph.D. - Faculty Profile

Biography

2022-present: joined the Cancer Biology graduate program

2021-present: Assistant Professor, Department of Immunology, UT Southwestern Medical Center, Dallas, TX

2021-present: Kidney Cancer Program, UT Southwestern Medical Center, Dallas, TX

2016-2021: Postdoctoral fellow, NIAMS, Bethesda, MD

2011-2016: Graduate student, University of Minnesota, Minneapolis, MN

Research Interest

Adaptive anti-viral immunity
T cell differentiation and function
Tumor immunology

Publications

Featured Publications

FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells.: Zhu Z, Lou G, Teng XL, Wang H, Luo Y, Shi W, Yihunie K, Hao S, DeGolier K, Liao C, Huang H, Zhang Q, Fry T, Wang T, Yao C, Wu T, Nat Immunol 2023 Nov
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells.: Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T, Nat Immunol 2021 03 22 3 370-380
Single-cell RNA-seq reveals TOX as a key regulator of CD8⁺ T cell persistence in chronic infection.: Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T, Nat. Immunol. 2019 07 20 7 890-901
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation.: Haque TT, Weissler KA, Schmiechen Z, Laky K, Schwartz DM, Li J, Locci M, Turfkruyer M, Yao C, Schaughency P, Leak L, Lack J, Kanno Y, O'Shea J, Frischmeyer-Guerrerio PA, Sci Immunol 2024 Jan 9 91 eadg8691
Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues.: Zheng M, Yao C, Ren G, Mao K, Chung H, Chen X, Hu G, Wang L, Luan X, Fang D, Li D, Zhong C, Lu X, Cannon N, Zhang M, Bhandoola A, Zhao K, O'Shea JJ, Zhu J, Cell Rep 2023 Aug 42 8 112924
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis.: Gauthier T, Yao C, Dowdy T, Jin W, Lim YJ, Patiño LC, Liu N, Ohlemacher SI, Bynum A, Kazmi R, Bewley CA, Mitrovic M, Martin D, Morell RJ, Eckhaus M, Larion M, Tussiwand R, O'Shea JJ, Chen W, Sci Signal 2023 Aug 16 797 eade0385
Facts and hopes for immunotherapy in renal cell carcinoma.: Yao C, Zhang T, Wu T, Brugarolas J, Clin Cancer Res 2022 Jul
MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.: Mikami Y, Philips RL, Sciumè G, Petermann F, Meylan F, Nagashima H, Yao C, Davis FP, Brooks SR, Sun HW, Takahashi H, Poholek AC, Shih HY, Afzali B, Muljo SA, Hafner M, Kanno Y, O'Shea JJ, Immunity 2021 Mar 54 3 514-525.e6
Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.: Razzaghi R, Agarwal S, Kotlov N, Plotnikova O, Nomie K, Huang DW, Wright GW, Smith GA, Li M, Takata K, Yamadi M, Yao C, O'Shea JJ, Phelan JD, Pittaluga S, Scott DW, Muppidi JR, J Exp Med 2021 Mar 218 3
Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.: Sciumè G, Mikami Y, Jankovic D, Nagashima H, Villarino AV, Morrison T, Yao C, Signorella S, Sun HW, Brooks SR, Fang D, Sartorelli V, Nakayamada S, Hirahara K, Zitti B, Davis FP, Kanno Y, O'Shea JJ, Shih HY, Immunity 2020 10 53 4 745-758.e4