Biography

Irina Timofte, M.D. M.S., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Pulmonary and Critical Care Medicine. Dr. Timofte specializes in lung transplantation.

Dr. Timofte received her medical degree from the Carol Davila University of Medicine in Bucharest, Romania. After completing her Pulmonary and Critical Care Fellowship at the University of Florida, and Lung Transplant Fellowship at the University of Pittsburgh, she became a lung transplant physician at the University of Maryland in 2013. As a fulltime clinical faculty member in the Department of Medicine at the University of Maryland School of Medicine, Dr. Timofte had substantial contributions to the ongoing performance improvement processes, leadership in the clinical setting, and expanding transplant clinical service. Dr. Timofte reorganized both the inpatient and outpatient Lung Transplant Program structure by developing protocols and guidelines, implementing an inpatient expedited lung transplant work-up, and reorganizing outpatient clinical workflow to improve quality and efficiency. Dr. Timofte also played a vital role in growing the outreach and referral basis by more than 50% and increasing the University of Maryland Medical Center’s lung transplant volumes by more than 30%.

In 2021, Dr. Timofte joined UT Southwestern Medical Center as Associate Professor.

Dr. Timofte's clinical interests cover advanced lung diseases: pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), connective tissue-related interstitial lung disease (ILD) (including scleroderma and rheumatoid arthritis-related ILD), pulmonary hypertension, and critical illness. Her practice focuses on the pre- and post-transplant care of lung transplant recipients, having actively and continuously managed these patients for nearly a decade. 

Dr. Timofte also completed a Master of Science in Epidemiology and Clinical Research at the University of Maryland School of Medicine.

Dr. Timofte’s research interests mirror her clinical interest and expertise. Her translational research focuses on discovering safer noninvasive diagnostic approaches to evaluate graft integrity and predict lung rejection though the integration of data obtained from cell-free DNA microbiome and microarray analyses. Her research goals are to improve clinical outcomes and develop superior immunosuppressive strategies for lung transplant patients by using a less toxic immunosuppressive regimen comprised of belatacept, inhaled cyclosporine, and/or sirolimus. Dr. Timofte has served as principal investigator and co-investigator in several NIH-sponsored clinical trials.

Dr. Timofte has been involved in medical education of medical students, residents and fellows and has served as the lung transplant rotation course director at the University of Maryland. Currently, at UT Southwestern Medical Center, Dr. Timofte is actively involved in mentoring and teaching pulmonary and critical care fellows.

Dr. Timofte is certified by the American Board of Internal Medicine in Internal Medicine, Critical Care Medicine, and Pulmonary Medicine. She is an active member of the International Society of Heart and Lung Transplantation.

She has published numerous academic articles and delivers international, national, and regional presentations.

Education

Medical School
Carol Davila University of Medicine & Pharmacy (2002)
Residency
Cleveland Clinic Foundation (2007), Internal Medicine
Fellowship
University of Florida Health Science Center (2012), Pulmonary & Critical Care Medicine
Fellowship
University of Pittsburgh Medical Center (2013)
Other Post Graduate Training
University of Maryland School of Medicine (2019)

Research Interest

  • Cell-free DNA
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Interstitial Lung Disease
  • Lung Transplantation
  • Metabolome
  • Microbiome
  • Pulmonary Fibrosis
  • Pulmonary Hypertension
  • Rejection and immunosuppression

Publications

Featured Publications LegendFeatured Publications

Dapsone as an Effective Treatment for Arthritis Secondary to Hidradenitis Suppurativa.
Timofte I, Smith H, Bull Hosp Jt Dis (2013) 2021 Jun 79 2 137-140
Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD).
Keller M, Bush E, Diamond JM, Shah P, Matthew J, Brown AW, Sun J, Timofte I, Kong H, Tunc I, Luikart H, Iacono A, Nathan SD, Khush KK, Orens J, Jang M, Agbor-Enoh S, J Heart Lung Transplant 2021 Jun 40 6 488-493
Donor-derived cell-free DNA accurately detects acute rejection in lung transplant patients, a multicenter cohort study.
Jang MK, Tunc I, Berry GJ, Marboe C, Kong H, Keller MB, Shah PD, Timofte I, Brown AW, Ponor IL, Mutebi C, Philogene MC, Yu K, Iacono A, Orens JB, Nathan SD, Agbor-Enoh S, J Heart Lung Transplant 2021 Apr
Molecular T-cell?mediated rejection in transbronchial and mucosal lung transplant biopsies is associated with future risk of graft loss.
Halloran K, Parkes MD, Timofte I, Snell G, Westall G, Havlin J, Lischke R, Hachem R, Kreisel D, Levine D, Kubisa B, Piotrowska M, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Hirji A, Weinkauf J, Halloran PF, J Heart Lung Transplant 2020 12 39 12 1327-1337
Survival benefit of lung transplantation compared with medical management and pulmonary rehabilitation for patients with end-stage COPD.
Timofte I, Wijesinha M, Vesselinov R, Kim J, Reed R, Sanchez PG, Ladikos N, Pham S, Kon Z, Rajagopal K, Scharf SM, Wise R, Sternberg AL, Kaczorowski D, Griffith B, Terrin M, Iacono A, ERJ Open Res 2020 Apr 6 2
Molecular phenotyping of rejection-related changes in mucosal biopsies from lung transplants.
Halloran K, Parkes MD, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Levine D, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Hirji A, Weinkauf J, Halloran PF, Am J Transplant 2020 04 20 4 954-966
Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease.
Timofte I, Tonelli A, Diaz-Abad M, Verceles A, Ladikos N, Iacono A, Terrin ML, Wijesinha M, Akindipe O, Baz M, Monaldi Arch Chest Dis 2020 Feb 90 1
A randomised single-centre trial of inhaled liposomal cyclosporine for bronchiolitis obliterans syndrome post-lung transplantation.
Iacono A, Wijesinha M, Rajagopal K, Murdock N, Timofte I, Griffith B, Terrin M, ERJ Open Res 2019 Oct 5 4
Molecular assessment of rejection and injury in lung transplant biopsies.
Halloran KM, Parkes MD, Chang J, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Trulock E, Roux A, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Halloran PF, J Heart Lung Transplant 2019 05 38 5 504-513
Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation.
Agbor-Enoh S, Wang Y, Tunc I, Jang MK, Davis A, De Vlaminck I, Luikart H, Shah PD, Timofte I, Brown AW, Marishta A, Bhatti K, Gorham S, Fideli U, Wylie J, Grimm D, Goodwin N, Yang Y, Patel K, Zhu J, Iacono A, Orens JB, Nathan SD, Marboe C, Berry GJ, Quake SR, Khush K, Valantine HA, EBioMedicine 2019 Feb 40 541-553

Honors & Awards

  • Certificate of Appreciation for Dedicated Service
    Cleveland Clinic (2009)

Professional Associations/Affiliations

  • International Society for Heart and Lung Transplantation