Walter Chen, M.D., Ph.D.

Instructor

Schools: Medical School
Departments: Pediatrics

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Education

Other Post Graduate Training: MIT (2016)
Medical School: Harvard Medical School (2018)
Residency: Boston Children's Hospital (2021), Pediatrics
Fellowship: UT Southwestern Medical Center (2024), Neonatal-perinatal Medicine

Publications

PEX39 facilitates the peroxisomal import of PTS2-containing proteins: Chen WW, Rodrigues TA, Wendscheck D, Pedrosa AG, Yang C, Francisco T, Möcklinghoff T, Zografakis A, Nunes-Silva B, Avraham RE, Silva AR, Ferreira MJ, Das H, Koster J, Neuwirth S, Bender J, Oeljeklaus S, Sondhi V, Gatsogiannis C, Schuldiner M, Zalckvar E, Hofmann K, Waterham HR, DeBerardinis RJ, Azevedo JE, Warscheid B Nature cell biology 2025 Aug 27 1256-1271
Technologies for Decoding Cancer Metabolism with Spatial Resolution: Chen WW, Pacold ME, Sabatini DM, Kanarek N Cold Spring Harbor Perspectives in Medicine 2025 Jul 15
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme: Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J Nature communications 2020 Dec 11
A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells: Ray GJ, Boydston EA, Shortt E, Wyant GA, Lourido S, Chen WW, Sabatini DM iScience 2020 May 23
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo: Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 116 303-312
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient: Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM Cell 2017 Oct 171 642-654.e12
Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites: Chen WW, Freinkman E, Sabatini DM Nature Protocols 2017 Oct 12 2215-2231
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras: Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM Cell 2017 Feb 168 890-903.e15
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism: Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM Cell 2016 Aug 166 1324-1337.e11
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate: Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM Nature chemical biology 2016 Jun 12 452-458