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Koorosh Mirpour, M.D., Ph.D.

Titles and Appointments

Assistant Professor

Schools
Medical School | Graduate School
Departments
Neurological Surgery
Graduate Programs
Neuroscience
  • Biography

    Dr. Koorosh Mirpour is an Assistant Professor at UT Southwestern Medical Center, specializing in electrophysiology and cognitive neuroscience. With over two decades of experience in neuroscience research, Dr. Mirpour focuses on uncovering the neural mechanisms underlying Parkinson’s disease, treatment-resistant depression (TRD), and cerebellar disorders. He is currently working closely with Pouratian Lab, directed by Dr. Nader Pouratian MD, PhD, Professor of Functional Neurosurgery and Chair of the Department. Dr. Mirpour previously conducted extensive research at UCLA, where he published influential studies on visual search behavior and neuronal processing. He holds an MD and PhD in Cognitive Neuroscience from the Institute for Studies in Theoretical Physics and Mathematics (IPM).

    Research Interests:

    Dr. Mirpour's research employs advanced electrophysiological methods, including local field potentials (LFP) and single-cell recordings, to study beta-frequency oscillations within the basal ganglia and their role in motor dysfunction in Parkinson’s disease. He actively participates in pioneering research studies examining deep brain stimulation (DBS) for motor disorders and treatment-resistant depression, collaborating closely with institutions such as Baylor College of Medicine. His work integrates statistics, modeling, and machine learning techniques to investigate neural mechanisms underlying brain diseases and develop individualized treatments aimed at enhancing patient outcomes. 

     

  • Publications

    Star Featured Publications

    Featured Featured Featured Featured
    Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.
    Choi JW, Alijanpourotaghsara A, Mirpour K, Chilukuri S, Pouratian N, Cell Rep Med 2026 Aug 103001
    Parkinson's disease severity is encoded by non-linear oscillatory interactions across cortical-subcortical networks.
    Chilukuri S, Alijanpourotaghsara A, Sharma VD, Bordelon Y, Pouratian N, Mirpour K, Sci Rep 2026 May
    Linking cortical morphology and neurophysiological dynamics in Parkinson's disease.
    Mirpour K, Alijanpourotaghsara A, Pouratian N, Sci Rep 2026 Mar
    A priority map is all you need: Exploring the roots of neural mechanisms underlying transformer-based large language models.
    Mirpour K, Bisley JW, Pouratian N, Psychol Rev 2026 Feb
    A Canonical Neural Map and Its Deviations Shape Parkinson's Disease Phenotypes.
    Mirpour K, Alijanpourotaghsara A, Sharma V, Bordelon Y, Pouratian N, Res Sq 2026 Jan
    Combinatorial effects of multi-site stimulation on depression-related brain regions: clinical data analysis and predictive modeling.
    Ghazavi A, Mirpour K, Soroush M, Bartoli E, Giridharan N, Oswalt D, Provenza NR, Allawala A, Goodman W, Sheth SA, Pouratian N, Front Psychiatry 2026 17 1808486