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Koorosh Mirpour, M.D., Ph.D.

Titles and Appointments

Assistant Professor

School
Medical School
Department
Neurological Surgery
  • Biography

    Dr. Koorosh Mirpour is an Assistant Professor at UT Southwestern Medical Center, specializing in electrophysiology and cognitive neuroscience. With over two decades of experience in neuroscience research, Dr. Mirpour focuses on uncovering the neural mechanisms underlying Parkinson’s disease, treatment-resistant depression (TRD), and cerebellar disorders. He is currently working closely with Pouratian Lab, directed by Dr. Nader Pouratian MD, PhD, Professor of Functional Neurosurgery and Chair of the Department. Dr. Mirpour previously conducted extensive research at UCLA, where he published influential studies on visual search behavior and neuronal processing. He holds an MD and PhD in Cognitive Neuroscience from the Institute for Studies in Theoretical Physics and Mathematics (IPM).

    Research Interests:

    Dr. Mirpour's research employs advanced electrophysiological methods, including local field potentials (LFP) and single-cell recordings, to study beta-frequency oscillations within the basal ganglia and their role in motor dysfunction in Parkinson’s disease. He actively participates in pioneering research studies examining deep brain stimulation (DBS) for motor disorders and treatment-resistant depression, collaborating closely with institutions such as Baylor College of Medicine. His work integrates statistics, modeling, and machine learning techniques to investigate neural mechanisms underlying brain diseases and develop individualized treatments aimed at enhancing patient outcomes. 

     

  • Publications

    Star Featured Publications

    Featured Featured Featured Featured
    B(RAIN)2-BRAIN integrated Resource for Anatomy and Intracranial Neurophysiology.
    Alijanpourotaghsara A, Mirpour K, Choi JW, Chitta KK, Shalaby A, Boswell M, Chilukuri S, Cohen SL, Byon R, Benam M, Kariv S, Lee J, Duncan D, Pouratian N, Sci Data 2025 Mar 12 1 442
    Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression.
    Hacker C, Mocchi MM, Xiao J, Metzger B, Adkinson J, Pascuzzi B, Mathura R, Oswalt D, Watrous A, Bartoli E, Allawala A, Pirtle V, Fan X, Danstrom I, Shofty B, Banks G, Zhang Y, Armenta-Salas M, Mirpour K, Provenza N, Mathew S, Cohn JF, Borton D, Goodman W, Pouratian N, Sheth SA, Bijanki KR, Biol Psychiatry Cogn Neurosci Neuroimaging 2025 Feb 10 2 186-194
    Suppression of frontal eye field neuronal responses with maintained fixation.
    Mirpour K, Bolandnazar Z, Bisley JW, Proc Natl Acad Sci U S A 2018 Jan 115 4 804-809