Yuki Obata, Ph.D.
Assistant Professor
Endowed Title Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell
School Medical School
Department Immunology | Neuroscience
Graduate Programs Immunology, Neuroscience
Biography
2021-Present: Assistant Professor, UT Southwestern Medical Center, Dallas, TX
2018-2021: Postdoctoral Fellow (HFSP Postdoctoral Fellow), The Francis Crick Institute, London, UK
2016-2017: Postdoctoral Fellow (EMBO Long-Term Postdoctoral Fellow), The Francis Crick Institute, London, UK
2015-2016: Postdoctoral Fellow (JSPS Superlative Postdoctoral Fellow, SPD), The Institute of Medical Science, The University of Tokyo, Japan
2010-2015: Graduate student, RIKEN (Joint Graduate School of Chiba University), Japan
Research Interest
- Chronoception
- Interoception
- Neuromicrobiology
Publications
Featured Publications
- Macrophages regulate gastrointestinal motility through complement component 1q.
- Pendse M, De Selle H, Vo N, Quinn G, Dende C, Li Y, Salinas CN, Srinivasan T, Propheter DC, Crofts AA, Koo E, Hassell B, Ruhn KA, Raj P, Obata Y, Hooper LV, Elife 2023 Apr 12
- Gut microbiota depletion minimally affects the daily voluntary wheel running activity and food anticipatory activity in female and male C57BL/6J mice.
- Ehichioya DE, Taufique SKT, Magaña I, Farah S, Obata Y, Yamazaki S, Front Physiol 2023 14 1299474
- Molecular profiling of enteric nervous system cell lineages.
- Obata Y, Castaño Á, Fallesen TL, Bon-Frauches AC, Boeing S, Huseynova A, McCallum S, Lasrado R, Heanue TA, Pachnis V, Nat Protoc 2022 Jun
- Neuronal programming by microbiota regulates intestinal physiology.
- Obata Y, Castaño Á, Boeing S, Bon-Frauches AC, Fung C, Fallesen T, de Agüero MG, Yilmaz B, Lopes R, Huseynova A, Horswell S, Maradana MR, Boesmans W, Vanden Berghe P, Murray AJ, Stockinger B, Macpherson AJ, Pachnis V, Nature 2020 02 578 7794 284-289
- The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System.
- Obata Y, Pachnis V, Gastroenterology 2016 11 151 5 836-844
- The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
- Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K, Nat Immunol 2014 Jun 15 6 571-9
- Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
- Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H, Nature 2013 Dec 504 7480 446-50
- Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon.
- Nakamura A, Kurihara S, Takahashi D, Ohashi W, Nakamura Y, Kimura S, Onuki M, Kume A, Sasazawa Y, Furusawa Y, Obata Y, Fukuda S, Saiki S, Matsumoto M, Hase K, Nat Commun 2021 04 12 1 2105
- Enteric glia as a source of neural progenitors in adult zebrafish.
- McCallum S, Obata Y, Fourli E, Boeing S, Peddie CJ, Xu Q, Horswell S, Kelsh RN, Collinson L, Wilkinson D, Pin C, Pachnis V, Heanue TA, Elife 2020 08 9
- Linking neurons to immunity: Lessons from Hydra.
- Obata Y, Pachnis V, Proc Natl Acad Sci U S A 2020 08 117 33 19624-19626
Honors & Awards
- Pew Biomedical Scholars
(2023) - Welch Research Grants
(2023) - UT Southwestern Endowed Scholar
(2021) - HFSP Long-Term Fellowship
(2017-2020) - EMBO Long-Term Fellowship
(2016-2017) - Inoue Research Award for Young Scientists
Inoue Foundation for Science (2016) - Ikushi Prize
Japan Society for the Promotion of Science (JSPS) (2015) - Superlative Postdoctoral Fellow (SPD)
Japan Society for the Promotion of Science (JSPS) (2015-2016)