Ying Xian, M.D., Ph.D. Section Head Research, Stroke & Cerebrovascular Diseases Associate Professor School Medical School Department Neurology Biography Joined UT Southwestern: 2021 Ying Xian, M.D., Ph.D., FAHA, is a tenured Associate Professor in the Department of Neurology at UT Southwestern Medical Center. Research: For more than a decade, Dr. Xian’s research has been focused on improving healthcare quality and outcomes in patients with cardiovascular disease and stroke. Before joining the UT Southwestern faculty in 2021, Dr. Xian served as the clinical lead for the AHA/ASA Get With The Guidelines Stroke (GWTG-Stroke) Registry and Society of Thoracic Surgeons (STS) National Database Analytical Center at Duke. He has led multiple groundbreaking comparative effectiveness and patient-centered outcomes research projects, with extensive experience with large national registries and data linkage with Medicare claims. Dr. Xian has authored or co-authored over 200 peer-reviewed publications and ranks among the World's Top 2% Scientists in clinical medicine by Stanford/Elsevier. He is the Principal Investigator of multiple National Institute on Aging (NIA) funded R01s to evaluate antithrombotic therapy for secondary stroke prevention and post-stroke dementia, and the AHA Clinical Research Program and Scientist Development Grant to investigate off-label/off-guideline thrombolytic therapy in stroke. Affiliations & Awards: He has been recognized for his research through the AHA QCOR Young Investigator Award and the Northwestern Junior Faculty Clinical Research Award. Dr. Xian has served on multiple committees of the AHA/ASA, including the GWTG Quality Improvement Subcommittee, Stroke Systems of Care Advisory Group, Stroke Council’s Quality and Outcomes Committee, Quality of Care and Outcomes Research (QCOR) Council’s Young Clinicians & Investigators Committee, and GWTG-Stroke Clinical Work Group. Background: Dr. Xian earned his medical degree at Beijing Medical University (Peking University Health Science Center), completed a residency in Internal Medicine, and a fellowship in Cardiology at Peking University People’s Hospital, and Fuwai Hospital, Peking Union Medical College. Dr. Xian obtained his Ph.D. degree in Health Services Research and Policy at the University of Rochester and received the American Heart Association/American Stroke Association (AHA/ASA) Pharmaceutical Roundtable-Spina Fellowship training in Cardiovascular Outcomes Research at Duke University. Research Interest Cardiovascular disease Cognitive impairment and dementia Comparative effectiveness research Global health Health services research Outcomes research Patient-centered outcomes research Primary and secondary prevention Quality improvement Stroke Publications Featured Publications Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program. Xian Y, Li S, Jiang T, Beon CD, Poudel R, Thomas K, Reeves MJ, Smith EE, Saver JL, Sheth KN, Messé SR, Schwamm LH, Fonarow GC, Stroke 2024 Nov 55 11 2599-2610 Mobile Stroke Unit Management in Patients With Acute Ischemic Stroke Eligible for Intravenous Thrombolysis. Mac Grory B, Sun JL, Alhanti B, Lusk J, Li F, Adeoye O, Furie K, Hasan D, Messe S, Sheth KN, Schwamm LH, Smith EE, Bhatt DL, Fonarow GC, Saver JL, Xian Y, Grotta J, JAMA Neurol 2024 Oct Traditional Chinese Medicine Compound (Tongxinluo) and Clinical Outcomes of Patients With Acute Myocardial Infarction: The CTS-AMI Randomized Clinical Trial. Yang Y, Li X, Chen G, Xian Y, Zhang H, Wu Y, Yang Y, Wu J, Wang C, He S, Wang Z, Wang Y, Wang Z, Liu H, Wang X, Zhang M, Zhang J, Li J, An T, Guan H, Li L, Shang M, Yao C, Han Y, Zhang B, Gao R, Peterson ED, JAMA 2023 Oct 330 16 1534-1545 Vitamin K Antagonists and Intracranial Hemorrhage After Endovascular Thrombectomy-Reply. Mac Grory B, Xian Y, JAMA 2023 Oct 330 15 1490-1491 Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke. Mac Grory B, Holmes DN, Matsouaka RA, Shah S, Chang CWJ, Rison R, Jindal J, Holmstedt C, Logan WR, Corral C, Mackey JS, Gee JR, Bonovich D, Walker J, Gropen T, Benesch C, Dissin J, Pandey H, Wang D, Unverdorben M, Hernandez AF, Reeves M, Smith EE, Schwamm LH, Bhatt DL, Saver JL, Fonarow GC, Peterson ED, Xian Y, JAMA 2023 Jun 329 23 2038-2049 To Treat or Not to Treat: Low-Dose Alteplase for Patients With Acute Ischemic Stroke Taking Direct Oral Anticoagulants Within 24?Hours. Kam W, Xian Y, J Am Heart Assoc 2022 Sep e027238 Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke. Xian Y, Xu H, Matsouaka R, Laskowitz DT, Maisch L, Hannah D, Smith EE, Fonarow GC, Bhatt DL, Schwamm LH, Mac Grory B, Feng W, Fosbøl EL, Peterson ED, Johnson M, JAMA Netw Open 2022 Jul 5 7 e2224157 Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice. Smith EE, Zerna C, Solomon N, Matsouaka R, Mac Grory B, Saver JL, Hill MD, Fonarow GC, Schwamm LH, Messé SR, Xian Y, JAMA Neurol 2022 Jun Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants and Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase-Reply. Kam W, Xian Y, JAMA 2022 06 327 23 2355 Evaluation of Evidence-Based Dual Antiplatelet Therapy for Secondary Prevention in US Patients With Acute Ischemic Stroke. Xian Y, Xu H, Smith EE, Fonarow GC, Bhatt DL, Schwamm LH, Peterson ED, JAMA Intern Med 2022 Mar Results 1-10 of 232 1 2 3 4 5 Next Last Books Featured Books Data Resources. In Understanding Clinical Research Renato Lopes and Robert Harrington (2013). McGraw-Hill Education / Medical Honors & Awards 2nd Place Winner, Junior Faculty Clinical Category Young Investigator Research Award12th Annual Northwestern Cardiovascular Young Investigators' Forum (2016) FellowAmerican Heart Association (2016) Travel AwardInternational Stroke Conference (2016) Distinguished Clinical Research Achievement AwardClinical Research Forum. Fonarow GC, Zhao X, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Xian Y, Hernandez AF, Peterson ED, and Schwamm LH. Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA. 2014, 311(16), 1632-1640 (2015) 2nd Place Winner, Junior Faculty Clinical Track10th Annual Northwestern Cardiovascular Young Investigators' Forum (2014) Young Investigator FinalistAmerican Heart Association Epidemiology and Prevention|Nutrition, Physical Activity and Metabolism Scientific Sessions (2011) Young Investigator AwardAmerican Heart Association Quality of Care and Outcomes Research Interdisciplinary Council (2010) Bertram Scott Research FellowAmerican Heart Association Founders Affiliate (2008) Predoctoral FellowshipAmerican Heart Association Founders Affiliate (2008) Excellus Fellowship in Health Services Research and PolicyExcellus BCBS (2005) Dean's FellowshipUniversity of Rochester (2003) Professional Associations/Affiliations African Stroke Organization (2021) Alzheimer's Association (2024) American Heart Association (2007) European Stroke Organisation (2018) Gerontological Society of America (2021) World Stroke Organization (2019)
