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Ying Xian, M.D.,  Ph.D.

Ying Xian, M.D., Ph.D.

Section Head Research, Stroke & Cerebrovascular Diseases

Associate Professor

School
Medical School
Department
Neurology
  • Biography

    Joined UT Southwestern: 2021

    Ying Xian, M.D., Ph.D., FAHA, is a tenured Associate Professor in the Department of Neurology at UT Southwestern Medical Center.

    Research: For more than a decade, Dr. Xian’s research has been focused on improving healthcare quality and outcomes in patients with cardiovascular disease and stroke. Before joining the UT Southwestern faculty in 2021, Dr. Xian served as the clinical lead for the AHA/ASA Get With The Guidelines Stroke (GWTG-Stroke) Registry and Society of Thoracic Surgeons (STS) National Database Analytical Center at Duke. He has led multiple groundbreaking comparative effectiveness and patient-centered outcomes research projects, with extensive experience with large national registries and data linkage with Medicare claims.

    Dr. Xian has authored or co-authored over 200 peer-reviewed publications and ranks among the World's Top 2% Scientists in clinical medicine by Stanford/Elsevier. He is the Principal Investigator of the National Institute on Aging (NIA) funded R01s to evaluate antithrombotic therapy for secondary stroke prevention and post-stroke dementia, and the AHA Clinical Research Program and Scientist Development Grant to investigate off-label/off-guideline thrombolytic therapy in stroke.

    Affiliations & Awards: He has been recognized for his research through the AHA QCOR Young Investigator Award and the Northwestern Junior Faculty Clinical Research Award. Dr. Xian has served on multiple committees of the AHA/ASA, including the GWTG Quality Improvement Subcommittee, Stroke Systems of Care Advisory Group, Stroke Council’s Quality and Outcomes Committee, Quality of Care and Outcomes Research (QCOR) Council’s Young Clinicians & Investigators Committee, and GWTG-Stroke Clinical Work Group. 

    Background: Dr. Xian earned his medical degree at Beijing Medical University (Peking University Health Science Center), completed a residency in Internal Medicine, and a fellowship in Cardiology at Peking University People’s Hospital, and Fuwai Hospital, Peking Union Medical College. Dr. Xian obtained his Ph.D. degree in Health Services Research and Policy at the University of Rochester and received the American Heart Association/American Stroke Association (AHA/ASA) Pharmaceutical Roundtable-Spina Fellowship training in Cardiovascular Outcomes Research at Duke University. 

  • Research Interest
    • Cardiovascular disease
    • Cognitive impairment and dementia
    • Comparative effectiveness research
    • Global health
    • Health services research
    • Outcomes research
    • Patient-centered outcomes research
    • Primary and secondary prevention
    • Quality improvement
    • Stroke
  • Publications
    Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research
    de Havenon A, Ayodele I, Alhanti B, Mac Grory B, Xian Y, Fonarow G, Smith EE, Worrall BB Neurology 2024 Jun 102 e209424
    Time to Anticoagulation Reversal and Outcomes after Intracerebral Hemorrhage
    Sheth KN, Solomon N, Alhanti B, Messe SR, Xian Y, Bhatt DL, Hemphill JC, Frontera JA, Chang RC, Danelich IM, Huang J, Schwamm L, Smith EE, Goldstein JN, Mac Grory B, Fonarow GC, Saver JL JAMA neurology 2024 Apr 81 363-372
    Trends in Stroke Thrombolysis Care Metrics and Outcomes by Race and Ethnicity, 2003-2021
    Man S, Solomon N, Mac Grory B, Alhanti B, Saver JL, Smith EE, Xian Y, Bhatt DL, Schwamm LH, Uchino K, Fonarow GC JAMA Network Open 2024 Feb 7 E2352927
    Higher Procedural Volumes Are Associated with Faster Treatment Times, Better Functional Outcomes, and Lower Mortality in Patients Undergoing Endovascular Treatment for Acute Ischemic Stroke
    Nogueira RG, Haussen DC, Smith EE, Sun JL, Xian Y, Alhanti B, Blanco R, Mac Grory B, Doheim MF, Bhatt DL, Fonarow GC, Hassan AE, Joundi RA, Mocco J, Frankel MR, Schwamm LH Annals of Neurology 2024 Jan 95 146-155
    Thrombolysis for ischaemic stroke despite direct oral anticoagulation
    Purrucker JC, Meinel TR, Wilson D, Xian Y, Wu TY, Seiffge DJ Stroke and Vascular Neurology 2024
    Performance of Thrombectomy-Capable, Comprehensive, and Primary Stroke Centers in Reperfusion Therapies for Acute Ischemic Stroke: Report From the Get With The Guidelines-Stroke Registry
    Raychev R, Sun JL, Schwamm L, Smith EE, Fonarow GC, Messé SR, Xian Y, Chiswell K, Blanco R, Mac Grory B, Saver JL Circulation 2023 Dec 148 2019-2028
    Association between perceived risk of Alzheimer's disease and related dementias and cognitive function among U.S. older adults
    Wang N, Xu H, West JS, Østbye T, Wu B, Xian Y, Dupre ME Archives of Gerontology and Geriatrics 2023 Dec 115
    Atrial fibrillation as a novel risk factor for retinal stroke: A protocol for a population-based retrospective cohort study
    Lusk JB, Wilson L, Nalwade V, Song A, Schrag M, Biousse V, Li F, Poli S, Piccini J, Xian Y, O’Brien E, Grory BM PloS one 2023 Dec 18
    Traditional Chinese Medicine Compound (Tongxinluo) and Clinical Outcomes of Patients with Acute Myocardial Infarction: The CTS-AMI Randomized Clinical Trial
    Yang Y, Li X, Chen G, Xian Y, Zhang H, Wu Y, Yang Y, Wu J, Wang C, He S, Wang Z, Wang Y, Wang Z, Liu H, Wang X, Zhang M, Zhang J, Li J, An T, Guan H, Li L, Shang M, Yao C, Han Y, Zhang B, Gao R, Peterson ED JAMA 2023 Oct 330 1534-1545
    Vitamin K Antagonists and Intracranial Hemorrhage after Endovascular Thrombectomy - Reply
    Mac Grory B, Xian Y JAMA 2023 Oct 330 1490-1491
  • Books

    Featured 

    Data Resources. In Understanding Clinical Research

    Renato Lopes and Robert Harrington (2013). McGraw-Hill Education / Medical

  • Honors & Awards
    • 2nd Place Winner, Junior Faculty Clinical Category Young Investigator Research Award
      12th Annual Northwestern Cardiovascular Young Investigators' Forum (2016)
    • Fellow
      American Heart Association (2016)
    • Travel Award
      International Stroke Conference (2016)
    • Distinguished Clinical Research Achievement Award
      Clinical Research Forum. Fonarow GC, Zhao X, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Xian Y, Hernandez AF, Peterson ED, and Schwamm LH. Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA. 2014, 311(16), 1632-1640 (2015)
    • 2nd Place Winner, Junior Faculty Clinical Track
      10th Annual Northwestern Cardiovascular Young Investigators' Forum (2014)
    • Young Investigator Finalist
      American Heart Association Epidemiology and Prevention|Nutrition, Physical Activity and Metabolism Scientific Sessions (2011)
    • Young Investigator Award
      American Heart Association Quality of Care and Outcomes Research Interdisciplinary Council (2010)
    • Bertram Scott Research Fellow
      American Heart Association Founders Affiliate (2008)
    • Predoctoral Fellowship
      American Heart Association Founders Affiliate (2008)
    • Excellus Fellowship in Health Services Research and Policy
      Excellus BCBS (2005)
    • Dean's Fellowship
      University of Rochester (2003)
  • Professional Associations/Affiliations
    • African Stroke Organization (2021)
    • Alzheimer's Association (2024)
    • American Heart Association (2007)
    • European Stroke Organisation (2018)
    • Gerontological Society of America (2021)
    • World Stroke Organization (2019)