Bin Cai, Ph.D., is an Associate Professor and Director of Advanced Physics Service in UT Southwestern Medical Center’s Department of Radiation Oncology’s Division of Medical Physics & Engineering.

Dr. Cai received his Ph.D. from Ohio University and completed his medical physics residency training at Washington University’s School of Medicine. Prior to joining UT Southwestern, Dr. Cai was an Assistant Professor of Radiation Oncology at Washington University. He is certified in therapeutic radiological physics by the American Board of Radiology.

Dr. Cai has extensive clinical and research experience in radiation therapeutic physics, imaging processing, and computational programming. Specifically, Dr. Cai has been continuously working on clinical implementation, development, and improvement of advanced radiation therapy treatment technologies and procedures, including both MR and CT online adaptive radiotherapy, biology-guided radiotherapy, AI-assisted radiotherapy process, automated quality assurance, as well as risk analysis/process improvement for radiotherapy workflow.


Graduate School
Ohio University (2011), Arts and Science

Research Interest

  • Adaptive radiotherapy
  • Automation and artificial intelligence in modern radiation therapy
  • Biology-guided radiotherapy
  • MR-guided radiotherapy


NRG Oncology Assessment of Artificial Intelligence Deep Learning–Based Auto-segmentation for Radiation Therapy: Current Developments, Clinical Considerations, and Future Directions
Rong Y, Chen Q, Fu Y, Yang X, Al-Hallaq HA, Wu QJ, Yuan L, Xiao Y, Cai B, Latifi K, Benedict SH, Buchsbaum JC, Qi XS International Journal of Radiation Oncology Biology Physics 2024 May 119 261-280
BIOGUIDE-X: A First-in-Human Study of the Performance of Positron Emission Tomography-Guided Radiation Therapy
Vitzthum LK, Surucu M, Gensheimer MF, Kovalchuk N, Han B, Pham D, Chang D, Shirvani SM, Aksoy D, Maniyedath A, Narayanan M, Da Silva AJ, Mazin S, Feghali KA, Iyengar P, Dan T, Pompos A, Timmerman R, Öz O, Cai B, Garant A International Journal of Radiation Oncology Biology Physics 2024 Apr 118 1172-1180
Adaptive Radiotherapy: Next-Generation Radiotherapy
Dona Lemus OM, Cao M, Cai B, Cummings M, Zheng D Cancers 2024 Mar 16
Simulation and pre-planning omitted radiotherapy (SPORT): a feasibility study for prostate cancer
Zhuang T, Parsons D, Desai N, Gibbard G, Keilty D, Lin MH, Cai B, Nguyen D, Chiu T, Godley A, Pompos A, Jiang S Biomedical Physics and Engineering Express 2024 Mar 10
Beyond conventional bounds: Surpassing system limits for stereotactic ablative (SAbR) lung radiotherapy using CBCT-based adaptive planning system
Gonzalez Y, Visak J, Overman L, Liao CY, Yen A, Zhuang T, Cai B, Godley A, Zhang Y, Timmerman R, Iyengar P, Westover K, Parsons D, Lin MH Journal of applied clinical medical physics 2024
Inter-fractional portability of deep learning models for lung target tracking on cine imaging acquired in MRI-guided radiotherapy
Peng J, Stowe HB, Samson PP, Robinson CG, Yang C, Hu W, Zhang Z, Kim T, Hugo GD, Mazur TR, Cai B Physical and Engineering Sciences in Medicine 2024
Adapt-On-Demand: A Novel Strategy for Personalized Adaptive Radiation Therapy for Locally Advanced Lung Cancer
Li R, Zhuang T, Montalvo S, Wang K, Parsons DD, Zhang Y, Iyengar P, Wang J, Godley A, Cai B, Lin M, Westover K Practical Radiation Oncology 2024
Preliminary Evaluation of PTV Margins for Online Adaptive Radiation Therapy of the Prostatic Fossa
Morgan HE, Wang K, Yan Y, Desai N, Hannan R, Chambers E, Cai B, Lin MH, Sher DJ, Wang J, Wang AZ, Jiang S, Timmerman R, Park C“, Garant A Practical Radiation Oncology 2023 Jul 13 e345-e353
Phantom-based Quality Assurance of a Clinical Dose Accumulation Technique Used in an Online Adaptive Radiation Therapy Platform
Maraghechi B, Mazur T, Lam D, Price A, Henke L, Kim H, Hugo GD, Cai B Advances in Radiation Oncology 2023 May 8
Toward real-time automatic treatment planning (RTTP) with a one-step 3D fluence map prediction method and (nonorthogonal) convolution technique
Peng J, Yang C, Guo H, Shen L, Zhang M, Wang J, Zhang Z, Cai B, Hu W Computer Methods and Programs in Biomedicine 2023 Apr 231

Professional Associations/Affiliations

  • American Association of Physicists in Medicine (AAPM) (2012)
  • American Society for Radiation Oncology (ASTRO) (2016)
  • Radiation Research Society (RRS) (2016)