2021-Present: Assistant Professor, Department of Immunology, UT Southwestern Medical Center
2014-2020: Postdoctoral Fellow, Division of Immunology and Pathogenesis, University of California Berkeley
2008-2014: Graduate Student, Department of Biochemistry and Molecular Biology, University of Chicago


Research Interest

  • Host-Pathogen Interactions
  • Innate Immunity
  • Mechanisms of Immune Recognition


Featured Publications LegendFeatured Publications

Molecular characterization of a fungal gasdermin-like protein.
Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NL, Proc Natl Acad Sci U S A 2020 08 117 31 18600-18607
Defusing inflammasomes.
Sandstrom A, Vance RE, J Exp Med 2018 03 215 3 723-724
The CD3 conformational change in the ?d T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA, Cell Rep 2014 Jun 7 5 1704-1715
The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V?9Vd2 T cells.
Sandstrom A, Peigné CM, Léger A, Crooks JE, Konczak F, Gesnel MC, Breathnach R, Bonneville M, Scotet E, Adams EJ, Immunity 2014 Apr 40 4 490-500
The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ, J Biol Chem 2012 Sep 287 39 32780-90
?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
Sandstrom A, Scharf L, McRae G, Hawk AJ, Meredith SC, Adams EJ, J Biol Chem 2012 Feb 287 8 6035-43
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Rizk SS, Paduch M, Heithaus JH, Duguid EM, Sandstrom A, Kossiakoff AA, Nat Struct Mol Biol 2011 Apr 18 4 437-42
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM, Proc Natl Acad Sci U S A 2009 May 106 18 7437-42