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Andrew Sandstrom, Ph.D.

Andrew Sandstrom, Ph.D.

Assistant Professor

Endowed Title
Virginia Murchison Linthicum Scholar in Medical Research
School
Medical School
Department
Immunology
Graduate Programs
Immunology, Molecular Microbiology
  • Biography

    2021-Present: Assistant Professor, Department of Immunology, UT Southwestern Medical Center
    2014-2020: Postdoctoral Fellow, Division of Immunology and Pathogenesis, University of California Berkeley
    2008-2014: Graduate Student, Department of Biochemistry and Molecular Biology, University of Chicago

     

  • Research Interest
    • Host-Pathogen Interactions
    • Innate Immunity
    • Mechanisms of Immune Recognition
  • Publications

    Star Featured Publications

    Featured
    The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.
    Mitchell PS, Sandstrom A, Vance RE, Curr Opin Immunol 2019 10 60 37-45
    Featured
    Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.
    Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE, Science 2019 04 364 6435
    Molecular characterization of a fungal gasdermin-like protein.
    Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NL, Proc Natl Acad Sci U S A 2020 08 117 31 18600-18607
    Defusing inflammasomes.
    Sandstrom A, Vance RE, J Exp Med 2018 03 215 3 723-724
    The CD3 conformational change in the ?d T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
    Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA, Cell Rep 2014 Jun 7 5 1704-1715
    The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V?9Vd2 T cells.
    Sandstrom A, Peigné CM, Léger A, Crooks JE, Konczak F, Gesnel MC, Breathnach R, Bonneville M, Scotet E, Adams EJ, Immunity 2014 Apr 40 4 490-500
    The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
    Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ, J Biol Chem 2012 Sep 287 39 32780-90
    ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
    Sandstrom A, Scharf L, McRae G, Hawk AJ, Meredith SC, Adams EJ, J Biol Chem 2012 Feb 287 8 6035-43
    Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
    Rizk SS, Paduch M, Heithaus JH, Duguid EM, Sandstrom A, Kossiakoff AA, Nat Struct Mol Biol 2011 Apr 18 4 437-42
    Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
    Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM, Proc Natl Acad Sci U S A 2009 May 106 18 7437-42