Dr. Gruber is a faculty member in the Department of Internal Medicine, Division of Hematology/Oncology, and the Green Center for Reproductive Sciences. He is a physician-scientist that specializes in laboratory and clinical research, as well as patient care, for patients with breast cancer and other malignancies.

Dr. Gruber is originally from San Diego, CA and received his undergraduate and MD/PhD degrees from the University of Pennsylvania. He trained at Stanford University in Internal Medicine and Medical Oncology. He completed postdoctoral research in the Department of Genetics and was an Instructor in the Department of Medicine, Medical Oncology division where he saw patients in the Stanford Cancer Center. He is certified by the American Board of Internal Medicine in Internal Medicine (2015) and Medical Oncology (2017). He joined UT Southwestern in 2021.

Dr. Gruber is an expert at growth control pathways and chromatin biology in breast cancer and other malignancies. He is an accomplished clinical investigator in the fields of cancer genetics, metastatic breast cancer and triple-negative breast cancer. He came to UT Southwestern to continue his career as a physician-scientist to improve research and clinical care for cancer patients. Here he runs a research group dedicated to identifying new targets for the treatment of breast cancer and other malignancies. His laboratory develops chemical and genetic tools to decipher cell growth control pathways in the hopes that these will become precursors to new cancer drugs. He is a breast cancer physician at the Harold C. Simmons Comprehensive Cancer Center where he specializes in treatment and clinical research for patents with metastatic breast cancer and triple-negative breast cancer, and studies new immunotherapies. Dr. Gruber’s interests outside of medicine include his family, outdoor activities including hiking, nature, golf, tennis, skateboarding, as well as reading and writing.


Medical School
University of Pennsylvania Hospital (2011)
Stanford University Medical Center (2013), Internal Medicine
Stanford University Hospital (2016), Medical Oncology

Research Interest

  • Cancer biology
  • Cancer drug discovery
  • Cancer metabolism
  • Chromatin synthesis and maintenance
  • Epigenetic enzymes
  • immunoreceptors including VISTA
  • triple-negative breast cancer


Featured Publications LegendFeatured Publications

Association of Tumor-Infiltrating Lymphocytes with Homologous Recombination Deficiency and BRCA1/2 Status in Patients with Early Triple-Negative Breast Cancer: A Pooled Analysis.
Telli ML, Chu C, Badve SS, Vinayak S, Silver DP, Isakoff SJ, Kaklamani V, Gradishar W, Stearns V, Connolly RM, Ford JM, Gruber JJ, Adams S, Garber J, Tung N, Neff C, Bernhisel R, Timms KM, Richardson AL, Clin Cancer Res 2020 06 26 11 2704-2710
Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia.
Li Y, Gruber JJ, Litzenburger UM, Zhou Y, Miao YR, LaGory EL, Li AM, Hu Z, Yip M, Hart LS, Maris JM, Chang HY, Giaccia AJ, Ye J, Cell Death Dis 2020 02 11 2 102
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility.
Stowers RS, Shcherbina A, Israeli J, Gruber JJ, Chang J, Nam S, Rabiee A, Teruel MN, Snyder MP, Kundaje A, Chaudhuri O, Nat Biomed Eng 2019 12 3 12 1009-1019
High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients.
Chen J, Haanpää MK, Gruber JJ, Jäger N, Ford JM, Snyder MP, Clin Cancer Res 2019 09 25 17 5301-5314
Chromatin Remodeling in Response to BRCA2-Crisis.
Gruber JJ, Chen J, Geller B, Jäger N, Lipchik AM, Wang G, Kurian AW, Ford JM, Snyder MP, Cell Rep 2019 08 28 8 2182-2193.e6
Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid.
Liu Q, Van Bortle K, Zhang Y, Zhao MT, Zhang JZ, Geller BS, Gruber JJ, Jiang C, Wu JC, Snyder MP, Sci Rep 2018 08 8 1 12960
Outstanding Questions in the Clinical Management of Triple-Negative Breast Cancer.
Gruber JJ, Telli ML, J Oncol Pract 2017 05 13 5 305-307
Association of AHSG with alopecia and mental retardation (APMR) syndrome.
Reza Sailani M, Jahanbani F, Nasiri J, Behnam M, Salehi M, Sedghi M, Hoseinzadeh M, Takahashi S, Zia A, Gruber J, Lynch JL, Lam D, Winkelmann J, Amirkiai S, Pang B, Rego S, Mazroui S, Bernstein JA, Snyder MP, Hum Genet 2017 03 136 3 287-296
Differentiated thyroid cancer: focus on emerging treatments for radioactive iodine-refractory patients.
Gruber JJ, Colevas AD, Oncologist 2015 Feb 20 2 113-26

Honors & Awards

  • NIH/NCI Mentored Clinical Scientist Research Career Development Award
  • SPARK Translational Research Award
    Stanford University (2020)
  • Women's Cancer Center Innovation Award
    Stanford Cancer Institute (2020)
  • Innovation Award
    Stanford Cancer Institute (2017)
  • Young Investigator Award
    Conquer Cancer Foundation of ASCO (2017)

Professional Associations/Affiliations

  • Member Graduate Faculty of Biological Chemistry graduate program (2021)
  • American Association for Cancer Research (2017)
  • American Society of Clinical Oncology (2016)