Samir Parikh, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and Chief of the Division of Nephrology. He holds the Robert Tucker Hayes Distinguished Chair in Nephrology in honor of Dr. Floyd C. Rector, Jr., and the Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology. He also holds a secondary appointment as Professor of Pharmacology, and is a full member of the Cellular and Molecular Graduate Program.
Dr. Parikh holds a bachelor's degree in chemistry from Harvard College in Cambridge, Massachusetts, where he graduated magna cum laude. He earned his medical degree at Vanderbilt University School of Medicine in Nashville, Tennessee, where he was the Founder' Medal Valedictorian of his graduating class. He completed both his residency in internal medicine and fellowship in nephrology at Beth Israel Deaconess Medical Center in Boston.
Certified by the American Board of Internal Medicine in Nephrology, he joined the UT Southwestern faculty in 2021. Previously, he served on the faculty at Harvard Medical School, starting as an Assistant Professor in 2010 and becoming a Professor in 2020. He also served as Associate Vice Chair for Reearch in the Department of Medicine at Beth Israel Deaconess Medical Center.
Dr. Parikh is a member of the American Society of Nephrology and the International Society of Nephrology. He serves on the editorial board of the Journal of the American Society of Nephrology, serves as guest editor for Proceedings of the National Academy of Sciences and he is an associate editor of Kidney 360.
He has delivered many presentations both nationally and internationally and has published widely in scholarly journals.
Among other honors, in 2021, Dr. Parikh received a faculty STARs Award from University of Texas.
- Medical School
- Vanderbilt University School of Medicine (2001)
- Beth Israel Deaconess Medical Center (2002)
- Beth Israel Deaconess Medical Center (2003), Internal Medicine
- Beth Israel Deaconess Medical Center (2006), Nephrology
- Acute Kidney Injury
- Critical Illness
- NAD+ and Mitochondrial Metabolism
- Vascular Biology
- Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.
- Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, Elife 2023 Aug 12
- TMEM16E regulates endothelial cell procoagulant activity and thrombosis.
- Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, J Clin Invest 2023 Jun 133 11
- Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation.
- Taguchi K, Elias BC, Sugahara S, Sant S, Freedman BS, Waikar SS, Pozzi A, Zent R, Harris RC, Parikh SM, Brooks CR, J Clin Invest 2022 Dec 132 23
- A new chapter in lipid signaling and kidney fibrosis.
- Idowu TO, Parikh SM, Sci Transl Med 2022 Aug 14 658 eadd2826
- Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
- Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, JCI Insight 2021 Sep
- An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.
- Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM, Cell Metab 2019 07 30 1 190-200.e6
- Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
- Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, Nature 2019 01 565 7737 96-100
- De novo NAD+ biosynthetic impairment in acute kidney injury in humans.
- Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, Nat Med 2018 09 24 9 1351-1359
- Tie2 protects the vasculature against thrombus formation in systemic inflammation.
- Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, J Clin Invest 2018 04 128 4 1471-1484
- Targeting Tie2 and the host vascular response in sepsis.
- Parikh SM, Sci Transl Med 2016 04 8 335 335fs9
Honors & Awards
- Southern Society for Clinical Investigation
- American Association of Physicians
- UT STARS Award
University of Texas (2021)
- Donald W. Seldin Award
American Society of Nephrology and American Heart Association (2019)
- Outstanding Investigator Award
National Heart, Lung, Blood Institutes (2018)
- Sir William Osler Award
Interurban Clinical Club (2018)
- American Society for Clinical Investigation
- Carl W. Gottschalk Award
American Society of Nephrology (2008)
- Founder's Medal
Vanderbilt University School of Medicine (2001)
- American Society of Nephrology
- International Society of Nephrology