Samir M Parikh, M.D.

Professor & Division Chief

Endowed Title: Robert Tucker Hayes Distinguished Chair in Nephrology, in Honor of Dr. Floyd C. Rector, Jr.; Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology
School: Medical School
Department: Internal Medicine | Pharmacology
Graduate Programs: Cell and Molecular Biology

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Biography

Samir Parikh, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and Chief of the Division of Nephrology. He holds the Robert Tucker Hayes Distinguished Chair in Nephrology in honor of Dr. Floyd C. Rector, Jr., and the Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology. Dr. Parikh holds a secondary appointment in the Department of Pharmacology.

Dr. Parikh graduated magna cum laude from Harvard with a degree in chemistry. He earned his medical degree from Vanderbilt, where he received the Founder’s Medal as valedictorian of his graduating class. He completed residency and fellowship training in Nephrology at Beth Israel Deaconess Medical Center in Boston. Prior to joining UT Southwestern in 2021, he served as Professor of Medicine at Harvard Medical School and Associate Vice Chair for Research in the Department of Medicine at BIDMC.

Dr. Parikh has received multiple honors for teaching and mentorship, having led programs funded by organizations including the Doris Duke Foundation and the National Institutes of Health to train undergraduates, post-baccalaureate students, medical students, residents, and fellows in research.

The Parikh laboratory's research into metabolic mechanisms of kidney resilience has been recognized with the 2018 Sir William Osler Award from the Interurban Clinical Club and the 2019 Donald Seldin Award from the American Society of Nephrology and the American Heart Association. Original research from the group has appeared in Nature, Nature Medicine, Science Translational Medicine, Cell Metabolism, the Journal of Clinical Investigation, and PNAS among other leading journals. Dr. Parikh was inducted into the American Society for Clinical Investigation in 2017 and the American Association of Physicians in 2021. He has delivered more than 200 invited lectures.

Dr. Parikh currently serves as Chairperson of the Pathobiology of Kidney Disease study section at the NIH. He was recently elected Executive Councilor and Secretary for the American Society of Nephrology. In 2026, Dr. Parikh will serve as President of ASN.

Education

Medical School: Vanderbilt University School of Medicine (2001)
Internship: Beth Israel Deaconess Medical Center (2002)
Residency: Beth Israel Deaconess Medical Center (2003), Internal Medicine
Fellowship: Beth Israel Deaconess Medical Center (2006), Nephrology

Research Interest

Acute Kidney Injury
Aging
Critical Illness
NAD+ and Mitochondrial Metabolism
Vascular Biology

Publications

Featured Publications

Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.: Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, Elife 2023 Aug 12
TMEM16E regulates endothelial cell procoagulant activity and thrombosis.: Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, J Clin Invest 2023 Jun 133 11
Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation.: Taguchi K, Elias BC, Sugahara S, Sant S, Freedman BS, Waikar SS, Pozzi A, Zent R, Harris RC, Parikh SM, Brooks CR, J Clin Invest 2022 Dec 132 23
A new chapter in lipid signaling and kidney fibrosis.: Idowu TO, Parikh SM, Sci Transl Med 2022 Aug 14 658 eadd2826
Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.: Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, JCI Insight 2021 Sep
An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.: Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM, Cell Metab 2019 07 30 1 190-200.e6
Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.: Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, Nature 2019 01 565 7737 96-100
De novo NAD⁺ biosynthetic impairment in acute kidney injury in humans.: Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, Nat Med 2018 09 24 9 1351-1359
Tie2 protects the vasculature against thrombus formation in systemic inflammation.: Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, J Clin Invest 2018 04 128 4 1471-1484
Targeting Tie2 and the host vascular response in sepsis.: Parikh SM, Sci Transl Med 2016 04 8 335 335fs9

Honors & Awards

American Association of Physicians
AAP (2021)
UT STARS Award
University of Texas (2021)
Donald W. Seldin Award
American Society of Nephrology and American Heart Association (2019)
Outstanding Investigator Award
National Heart, Lung, Blood Institutes (2018)
Sir William Osler Award
Interurban Clinical Club (2018)
American Society for Clinical Investigation
ASCI (2017)
Carl W. Gottschalk Award
American Society of Nephrology (2008)
Founder's Medal
Vanderbilt University School of Medicine (2001)

Professional Associations/Affiliations

American Association of Physicians (2021)
American Society for Clinical Investigation (2017)
American Society of Nephrology (2003)
International Society of Nephrology