Biography

Dr. Parikh was born and raised in New Jersey. He attended Harvard where he graduated magna cum laude with a degree in chemistry before matriculating at Vanderbilt for medical school. Among several honors, he received the Founder’s Medal for highest academic standing in his graduating class. Dr. Parikh completed internship, residency, and nephrology fellowship at Beth Israel Deaconess Medical Center and Harvard Medical School. He attained the rank of Professor of Medicine at Harvard before moving to Dallas.

Dr. Parikh’s research is focused on mechanisms of resilience to acute physiological stressors. His work has identified major components of the host vascular response to severe infections, including the role of the endothelial tyrosine kinase Tie2. More recent studies have focused on the response of metabolically active cells and tissues to noxious insults, where his group has defined novel actions of the mitochondrial biogenesis factor PGC1alpha and the central metabolic cofactor NAD+. The studies on NAD+ homeostasis have translated to ongoing clinical trials in acute kidney injury (AKI), a common yet orphan stress-induced syndrome. Work from his team has been published in Nature, Nature Medicine, JCI, Science Translational Medicine, PNAS, and other high-impact journals. The group is now applying these insights to study renal development, links between AKI and chronic kidney disease, and more general questions of aging.

Dr. Parikh’s mentorship and teaching have been recognized by multiple awards. Dr. Parikh is an elected member of the American Society for Clinical Investigation (ASCI, 2017) and the American Association of Physicians (AAP, 2021). He has received the Outstanding Investigator Award from the National Heart Lung Blood Institute, the Sir William Osler Award from the Interurban Clinical Club (2018), and the Donald W. Seldin Award from the American Society of Nephrology and the American Heart Association (2019). Dr. Parikh received a UT STARS award in 2021.

Education

Medical School
Vanderbilt University School of Medicine (2001)
Internship
Beth Israel Deaconess Medical Center (2002)
Residency
Beth Israel Deaconess Medical Center (2003), Internal Medicine
Fellowship
Beth Israel Deaconess Medical Center (2006), Nephrology

Research Interest

  • Acute Kidney Injury
  • Aging
  • Critical Illness
  • NAD+ and Mitochondrial Metabolism
  • Vascular Biology

Publications

Featured Publications LegendFeatured Publications

An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.
Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM, Cell Metab 2019 07 30 1 190-200.e6
Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, Nature 2019 01 565 7737 96-100
Increased synthesis of a coenzyme linked to longevity can combat disease.
Parikh SM, Nature 2018 11 563 7731 332-333
De novo NAD+ biosynthetic impairment in acute kidney injury in humans.
Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, Nat Med 2018 09 24 9 1351-1359
Tie2 protects the vasculature against thrombus formation in systemic inflammation.
Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, J Clin Invest 2018 04 128 4 1471-1484
Targeting Tie2 and the host vascular response in sepsis.
Parikh SM, Sci Transl Med 2016 04 8 335 335fs9
PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection.
Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM, Nature 2016 Mar 531 7595 528-32
Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.
Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM, Proc Natl Acad Sci U S A 2016 Mar 113 9 2472-7
Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.
Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM, Proc Natl Acad Sci U S A 2012 Jun 109 25 10024-9
PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice.
Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM, J Clin Invest 2011 Oct 121 10 4003-14

Honors & Awards

  • American Association of Physicians
    AAP (2021)
  • Donald Seldin Award
    American Society of Nephrology (2019)
  • Outstanding Investigator Award
    National Heart, Lung, Blood Institute (2018)
  • Sir William Osler Award
    Interurban Clinical Club (2018)
  • American Society of Clinical Investigation
    ASCI (2017)
  • Carl Gottschalk Award
    American Society of Nephrology (2008)
  • Founder's Medal
    Vanderbilt University School of Medicine (2001)

Professional Associations/Affiliations

  • American Society of Nephrology (2003)