Samir M Parikh, M.D. Titles and Appointments Professor & Division Chief Endowed Title Robert Tucker Hayes Distinguished Chair in Nephrology, in Honor of Dr. Floyd C. Rector, Jr.; Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology Schools Medical School | Graduate School Departments Internal Medicine | Pharmacology Graduate Programs Cell and Molecular Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Samir Parikh, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and Chief of the Division of Nephrology. He holds the Robert Tucker Hayes Distinguished Chair in Nephrology in honor of Dr. Floyd C. Rector, Jr., the Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology., and a secondary appointment in the Department of Pharmacology. Dr. Parikh graduated magna cum laude from Harvard concentrating in chemistry. He earned his medical degree from Vanderbilt, where he received the Founder’s Medal for highest academic standing. Prior to joining UT Southwestern, he served as Professor of Medicine at Harvard Medical School, a Director of the Center for Vascular Biology Research, and Associate Vice Chair for Research in the Department of Medicine at Beth Israel Deaconess. The Parikh laboratory researches vascular and metabolic mechanisms of organ resilience. Their work has been published in Science, Nature, Nature Medicine, Cell Metabolism, JCI, Blood, and PNAS. Dr. Parikh's contributions have been recognized with honors including the Sir William Osler Award and the Donald Seldin Award, and he has been elected to the ASCI, AAP, and ACCA. Dr. Parikh is deeply committed to mentorship, having trained more than 500 learners across all stages, many of whom now hold independent academic and leadership positions. He has served a major national leadership role in kidney research and policy, first as Chair of the NIH Pathobiology of Kidney Disease study section and now as the 59th President of the American Society of Nephrology. During his presidency, ASN has advanced national research priorities through the Transforming Kidney Health Research initiative and helped lead advocacy efforts culminating in passage of the Honoring our Living Donors (HOLD) Act. Dr. Parikh is also an active public communicator, with his work featured in outlets including The New York Times, The Washington Post, National Geographic, PBS, as well as national television, radio, and podcast appearances. Education Medical School Vanderbilt University School of Medicine (2001) Internship Beth Israel Deaconess Medical Center (2002) Residency Beth Israel Deaconess Medical Center (2003), Internal Medicine Fellowship Beth Israel Deaconess Medical Center (2006), Nephrology Research Interest Acute Kidney Injury Aging Critical Illness NAD+ and Mitochondrial Metabolism Vascular Biology Publications Featured Publications Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations. Huang H, Wang Y, Zsengeller ZK, Gorham JM, Vemireddy V, Clark AJ, Pan H, Dreyfuss JM, Jotwani V, Shlipak MG, Sarnak MJ, Parikh CR, Thiessen-Philbrook H, Katz R, Waikar SS, Lake NJ, Lek M, Shi W, Puiu D, Hong YS, Seidman JG, Arking DE, Parikh SM, Science 2025 Sep eadk7978 Cathepsin K cleavage of Angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis. Suzuki T, Loyde E, Chen S, Etzrodt V, Idowu TO, Clark AJ, Saade MC, Flores BM, Lu S, Birrane G, Vemireddy V, Seeliger B, David S, Parikh SM, J Clin Invest 2025 Mar Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor. Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, Elife 2023 Aug 12 TMEM16E regulates endothelial cell procoagulant activity and thrombosis. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, J Clin Invest 2023 Jun 133 11 Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation. Taguchi K, Elias BC, Sugahara S, Sant S, Freedman BS, Waikar SS, Pozzi A, Zent R, Harris RC, Parikh SM, Brooks CR, J Clin Invest 2022 Dec 132 23 Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19. Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, JCI Insight 2021 Sep An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM, Cell Metab 2019 07 30 1 190-200.e6 Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, Nature 2019 01 565 7737 96-100 De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, Nat Med 2018 09 24 9 1351-1359 Tie2 protects the vasculature against thrombus formation in systemic inflammation. Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, J Clin Invest 2018 04 128 4 1471-1484 Results 1-10 of 111 1 2 3 4 5 Next Last Honors & Awards American Society of NephrologyPresident (2026) American Clinical and Climatological AssociationACCA (2025) American Association of PhysiciansAAP (2021) UT STARS AwardUniversity of Texas (2021) Donald W. Seldin AwardAmerican Society of Nephrology and American Heart Association (2019) Outstanding Investigator AwardNational Heart, Lung, Blood Institutes (2018) Sir William Osler AwardInterurban Clinical Club (2018) American Society for Clinical InvestigationASCI (2017) Carl W. Gottschalk AwardAmerican Society of Nephrology (2008) Founder's MedalVanderbilt University School of Medicine (2001) Professional Associations/Affiliations American Association of Physicians (2021) American Clinical and Climatological Association (2025) American Society for Clinical Investigation (2017) American Society of Nephrology (2026)
