Dr. Shen emigrated from Taiwan as a teenager and graduated from Stanford University with honors in biological sciences. He received his M.D. from UC San Diego School of Medicine, and completed both internal medicine and hematology-oncology training at UT Southwestern. He was the recipient of the Eugene Frenkel Outstanding Teacher of the Year award.

He specializes in nonmalignant blood disorders and has a strong interest in hemostasis and thrombosis. Dr. Shen has an intimate collaboration with the transfusion medicine and hemostasis laboratory faculty. He is considered the local and regional expert in coagulation disorders.


Medical School
University of California at San Diego School of Medicine (1995)
UT Southwestern Medical Center (1996), Internal Medicine
UT Southwestern Medical Center (1998), Internal Medicine
UT Southwestern Medical Center (2004), Hematology Oncology

Research Interest

  • Antiphospholipid antibody syndrome
  • Heparin-induced thrombocytopenia
  • Thrombophilia testing
  • Thrombosis & Hemostasis


Featured Publications LegendFeatured Publications

Comparison of low fixed dose versus standard-dose rituximab to treat thrombotic thrombocytopenic purpura in the acute phase and preemptively during remission.
Reddy MS, Hofmann S, Shen YM, Nagalla S, Rambally S, Usmani A, Sarode R, Transfus. Apher. Sci. 2020 Jul 102885
The role of cardiovascular disease risk assessed by ASCVD score in primary thrombosis prophylaxis strategy among antiphospholipid antibody carriers.
Zuo Y, Udupa A, Fan J, Makris UE, Karp DR, Shen YM Lupus 2018 Aug 961203318796289
Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.
Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C Blood 2018 Mar
Identifying Additional Risk Factors for Thrombosis and Pregnancy Morbidities Among Antiphospholipid Antibodies Carriers.
Zuo Y, Fan J, Sarode R, Zhang S, Makris UE, Karp DR, Shen YM Clin. Appl. Thromb. Hemost. 2018 Jan 1076029618755946
Can an anti-Xa assay for low-molecular-weight heparin be used to assess the presence of rivaroxaban?
Yates SG, Smith S, Tharpe W, Shen YM, Sarode R Transfus. Apher. Sci. 2016 Jun
Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.
Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW PLoS ONE 2016 11 7 e0158757
Analysis of Thrombophilia Test Ordering Practices at an Academic Center: A Proposal for Appropriate Testing to Reduce Harm and Cost.
Shen YM, Tsai J, Taiwo E, Gavva C, Yates SG, Patel V, Frenkel E, Sarode R PLoS ONE 2016 11 5 e0155326
Characteristics and Outcomes of Renal Transplant Recipients with Hemolytic Uremic Syndrome in the United States.
Tanriover B, Lakhia R, Shen YM, Sandikci B, Saxena R, MacConmara M, Soyombo AA, Rajora N, Hardy MA Transplant Direct 2015 Nov 1 10
Long-term safety and efficacy of factor IX gene therapy in hemophilia B.
Nathwani AC, Reiss UM, Tuddenham EG, Rosales C, Chowdary P, McIntosh J, Della Peruta M, Lheriteau E, Patel N, Raj D, Riddell A, Pie J, Rangarajan S, Bevan D, Recht M, Shen YM, Halka KG, Basner-Tschakarjan E, Mingozzi F, High KA, Allay J, Kay MA, Ng CY, Zhou J, Cancio M, Morton CL, Gray JT, Srivastava D, Nienhuis AW, Davidoff AM N. Engl. J. Med. 2014 Nov 371 21 1994-2004
Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.
Ulrich V, Konaniah ES, Lee WR, Khadka S, Shen YM, Herz J, Salmon JE, Hui DY, Shaul PW, Mineo C J Am Heart Assoc 2014 Oct 3 5 e001369

Honors & Awards

  • Eugene P. Frenkel Outstanding Teacher of the Year
    UT Southwestern (2011)

Professional Associations/Affiliations

  • Hemophilia and Thrombosis Research Society (2009)
  • International Society on Thrombosis and Haemostasis (2003)
  • American Society of Hematology (2002)
  • American College of Physician (1998)