Dr. Isaac Chan is a physician-scientist who is dedicated to eliminating mortality associated with metastatic breast cancer. During his MD/PhD training at University of North Carolina and medical oncology fellowship at Johns Hopkins University, he developed the tools to execute a bench to bedside research vision that probes the relationship between breast cancer metastasis and the tumor environment. His research focuses 1) understanding how metastatic tumor cells can grow in distant organs and 2) discovering novel drug targets that activate a patient’s own immune cells to target metastatic cancer lesions. He chose UT Southwestern to launch his lab because of its strong laboratory-based history and foundation and the innumerable opportunities to apply basic science knowledge to clinical practice. In parallel to his research efforts, he continues to see patients, who inform and inspire his work in the lab. Outside of medicine, his interests include spending time with family and friends, cooking, and reading biographies and books on American history.


Other Post Graduate Training
University of North Carolina (2012)
Medical School
University of North Carolina at Chapel Hill School of Medicine (2014)
Boston University Medical Center (2016), Internal Medicine
Johns Hopkins University (2020), Medical Oncology

Research Interest

  • Breast Cancer
  • Cancer Metastasis
  • Tumor Immunology
  • Tumor Immunotherapy


Featured Publications LegendFeatured Publications

Cancer cells educate natural killer cells to a metastasis-promoting cell state.
Chan IS, Knútsdóttir H, Ramakrishnan G, Padmanaban V, Warrier M, Ramirez JC, Dunworth M, Zhang H, Jaffee EM, Bader JS, Ewald AJ, J Cell Biol 2020 Sep 219 9
Impact of the Current US Preventive Services Task Force Recommendations for Cervical Cancer Screening in Young Women 21 to 29 Years Old.
Morris CP, Chowsilpa S, Mustafa S, Chan I, Miller D, Maleki Z, Rodriguez EF, Am J Clin Pathol 2020 05 153 6 734-742
An Acquired Factor X Inhibitor: The Importance of Understanding Coagulation.
Chan IS, Ogunsile FJ, Am J Med 2017 Jul 130 7 e307-e308
Delayed Diagnosis of Disseminated Cryptococcosis with Associated Meningoencephalitis in an Immunocompetent Septuagenarian Host.
Chan IS, Chudasama R, Burrows AB, Am J Med 2017 Jan 130 1 e31-e32
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
Pereira TA, Syn WK, Machado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, Secor WE, Andrade ZA, Lambertucci JR, Diehl AM, Clin Sci (Lond) 2015 Nov 129 10 875-83
Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.
Xie G, Choi SS, Syn WK, Michelotti GA, Swiderska M, Karaca G, Chan IS, Chen Y, Diehl AM, Gut 2013 Feb 62 2 299-309
Hedgehog controls hepatic stellate cell fate by regulating metabolism.
Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM, Gastroenterology 2012 Nov 143 5 1319-1329.e11

Professional Associations/Affiliations

  • Society for Immunotherapy of Cancer (2020)
  • American Association for Cancer Research (2018)