Isaac Chan, M.D. Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Hematology Oncology. He specializes in immunotherapy, breast cancer, and metastatic cancer.
Dr. Chan earned both his doctoral degree in genetics and molecular signaling and his medical degree at the University of North Carolina at Chapel Hill. He completed a residency in internal medicine at Boston University and received advanced training through a medical oncology fellowship at the Johns Hopkins University School of Medicine.
During his MD/PhD training at University of North Carolina and medical oncology fellowship at Johns Hopkins University, he developed the tools to execute a bench to bedside research vision that probes the relationship between breast cancer metastasis and the tumor environment.
Certified by the American Board of Internal Medicine, he joined the UT Southwestern faculty in 2020.
Dr. Chan’s research involves understanding how to treat and prevent metastatic disease by studying the processes by which cancer cells spread. He has delivered numerous invited talks and published countless academic articles on this subject. is research focuses 1) understanding how metastatic tumor cells can grow in distant organs and 2) discovering novel drug targets that activate a patient’s own immune cells to target metastatic cancer lesions.
Additionally, he has written several op-ed pieces about patient-centered care, including for The Washington Post, and has also worked closely with patient advocates in breast cancer and the organization Guiding Researchers and Advocates to Scientific Partnerships (GRASP). Dr. Chan is a member of the American Association for Cancer Research and the Society for Immunotherapy of Cancer.
In 2019, he earned the Conquer Cancer Young Investigator Award in Breast Cancer from the American Society of Clinical Oncology Foundation.
He chose UT Southwestern to launch his lab because of its strong laboratory-based history and foundation and the innumerable opportunities to apply basic science knowledge to clinical practice. In parallel to his research efforts, he continues to see patients, who inform and inspire his work in the lab.
Outside of medicine, his interests include spending time with family and friends, cooking, and reading biographies and books on American history.
- Other Post Graduate Training
- University of North Carolina (2012)
- Medical School
- University of North Carolina at Chapel Hill School of Medicine (2014)
- Boston University Medical Center (2016), Internal Medicine
- Johns Hopkins University (2020), Medical Oncology
- Breast Cancer
- Cancer Metastasis
- Tumor Immunology
- Tumor Immunotherapy
- Cancer cells educate natural killer cells to a metastasis-promoting cell state.
- Chan IS, Knútsdóttir H, Ramakrishnan G, Padmanaban V, Warrier M, Ramirez JC, Dunworth M, Zhang H, Jaffee EM, Bader JS, Ewald AJ, J Cell Biol 2020 Sep 219 9
- Impact of the Current US Preventive Services Task Force Recommendations for Cervical Cancer Screening in Young Women 21 to 29 Years Old.
- Morris CP, Chowsilpa S, Mustafa S, Chan I, Miller D, Maleki Z, Rodriguez EF, Am J Clin Pathol 2020 05 153 6 734-742
- An Acquired Factor X Inhibitor: The Importance of Understanding Coagulation.
- Chan IS, Ogunsile FJ, Am J Med 2017 Jul 130 7 e307-e308
- Delayed Diagnosis of Disseminated Cryptococcosis with Associated Meningoencephalitis in an Immunocompetent Septuagenarian Host.
- Chan IS, Chudasama R, Burrows AB, Am J Med 2017 Jan 130 1 e31-e32
- Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
- Pereira TA, Syn WK, Machado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, Secor WE, Andrade ZA, Lambertucci JR, Diehl AM, Clin Sci (Lond) 2015 Nov 129 10 875-83
- Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.
- Xie G, Choi SS, Syn WK, Michelotti GA, Swiderska M, Karaca G, Chan IS, Chen Y, Diehl AM, Gut 2013 Feb 62 2 299-309
- Hedgehog controls hepatic stellate cell fate by regulating metabolism.
- Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM, Gastroenterology 2012 Nov 143 5 1319-1329.e11
- Society for Immunotherapy of Cancer (2020)
- American Association for Cancer Research (2018)