Madhab Sapkota, Ph.D.

Dr. Madhab Sapkota is an Assistant Instructor in the Department of Internal Medicine at UT Southwestern Medical Center. His research interests include antimicrobial resistance, antimicrobial discovery, and infectious diseases.

Dr. Sapkota joined the UT Southwestern Faculty in 2023.

Originally from Nepal, Dr. Sapkota holds a bachelor’s and doctorate degree from the University of Texas at Arlington and master’s degree from the Tarleton State University. After postdoctoral fellowship at UT Arlington, Dr. Sapkota joined the laboratory of Dr. Greenberg in the Department of Internal Medicine and completed the postdoctoral certificate in research in 2022.

Dr. Sapkota is interested in understanding how bacterial pathogens become resistant to antimicrobials and finding the way to deal with multidrug resistant infections. His long term research interest spans on how the human host can overcome the burden of multidrug resistant pathogens due to infections. His investigations have resulted in several publications in peer-reviewed journals. Additionally, he has presented his findings at scientific conferences throughout the United States.

Dr. Sapkota is an active member in several professional societies including the American Society for Microbiology, American Society for Clinical Pathology, and National Center for Faculty Development and Diversity.

Dr. Sapkota’s interests outside of medicine include his family, gardening, sports, and nature.

Graduate School

(2016)

• Antimicrobial Discovery
• Antimicrobial Resistance
• Bacterial Genetics
• Infectious Diseases

Featured Publications

Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration.

Westfall AK, Perry BW, Kamal AHM, Hales NR, Kay JC, Sapkota M, Schield DR, Pellegrino MW, Secor SM, Chowdhury SM, Castoe TA, BMC Genomics 2022 Jan 23 1 6

A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity.

Sapkota M, Adnan Qureshi M, Arif Mahmud S, Balikosa Y, Nguyen C, Boll JM, Pellegrino MW, Biol Open 2021 May 10 5

A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR.

Amin MR, Mahmud SA, Dowgielewicz JL, Sapkota M, Pellegrino MW, PLoS Genet 2020 Dec 16 12 e1009234

Discovery and characterization of New Delhi metallo-β-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae.

Kazi MI, Perry BW, Card DC, Schargel RD, Ali HB, Obuekwe VC, Sapkota M, Kang KN, Pellegrino MW, Greenberg DE, Castoe TA, Boll JM, J Antimicrob Chemother 2020 Oct 75 10 2843-2851

A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR.

Mahmud SA, Qureshi MA, Sapkota M, Pellegrino MW, PLoS Pathog 2020 Sep 16 9 e1008918

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Sapkota M, Marreddy RKR, Wu X, Kumar M, Hurdle JG, Anaerobe 2020 Feb 61 102129

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

Marreddy RKR, Wu X, Sapkota M, Prior AM, Jones JA, Sun D, Hevener KE, Hurdle JG, ACS Infect Dis 2019 Feb 5 2 208-217

• American Society for Clinical Pathology (ASCP)
• American Society for Microbiology (ASM)
• National Center for Faculty Development and Diversity (NCFDD)