Mahendran Chinnappan, Ph.D. Titles and Appointments Instructor School Medical School Department Dermatology Biography Dr. Mahendran Chinnappan is an Instructor in the Department of Dermatology at UT Southwestern Medical Center. His research focuses on the role of sex steroid hormones in regulating immune responses and barrier gene expression in atopic dermatitis. Dr. Chinnappan uses in vitro and in vivo models, including immune and hormone signaling gene–specific knockout mice, to investigate mechanisms underlying atopic dermatitis pathology. He earned his Ph.D. in Zoology from the University of Delhi, India, where he studied noncoding RNAs. His work aims to advance the understanding of dermatological conditions and support the development of targeted therapeutic strategies. Publications Featured Publications Human case of diphyllobothriasis in Australia. Khan SF, Koehler AV, Tinson A, Chinnappan M, Sheorey H, Gasser RB, Med J Aust 2025 Jan Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensing. John MS, Chinnappan M, Artami M, Bhattacharya M, Keogh RA, Kavanaugh J, Sharma T, Horswill AR, Harris-Tryon TA, bioRxiv 2024 Feb Chikungunya virus non-structural protein nsP3 interacts with Aedes aegypti DEAD-box helicase RM62F. Kumar R, Srivastava P, Mathur K, Shrinet J, Dubey SK, Chinnappan M, Kaur I, Nayak D, Chattopadhyay S, Bhatnagar RK, Sunil S, Virusdisease 2021 Dec 32 4 657-665 Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis. Zhang C, Chinnappan M, Prestwood CA, Edwards M, Artami M, Thompson BM, Eckert KM, Vale G, Zouboulis CC, McDonald JG, Harris-Tryon TA, Proc Natl Acad Sci U S A 2021 Sep 118 38 Novel mechanisms of microbial crosstalk with skin innate immunity. Chinnappan M, Harris-Tryon TA, Exp Dermatol 2021 Jul Exosomes as drug delivery vehicle and contributor of resistance to anticancer drugs. Chinnappan M, Srivastava A, Amreddy N, Razaq M, Pareek V, Ahmed R, Mehta M, Peterson JE, Munshi A, Ramesh R, Cancer Lett. 2020 Aug 486 18-28 Progress in extracellular vesicle biology and their application in cancer medicine. Srivastava A, Amreddy N, Pareek V, Chinnappan M, Ahmed R, Mehta M, Razaq M, Munshi A, Ramesh R, Wiley Interdiscip Rev Nanomed Nanobiotechnol 2020 Jul 12 4 e1621 Analysis of lncRNA-miRNA-mRNA Interactions in Hyper-proliferative Human Pulmonary Arterial Smooth Muscle Cells. Chinnappan M, Gunewardena S, Chalise P, Dhillon NK, Sci Rep 2019 07 9 1 10533 Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse. Sharma H, Chinnappan M, Agarwal S, Dalvi P, Gunewardena S, O'Brien-Ladner A, Dhillon NK, FASEB J. 2018 09 32 9 5174-5185 Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV-Associated Pulmonary Vascular Remodeling. Chinnappan M, Mohan A, Agarwal S, Dalvi P, Dhillon NK, J Am Heart Assoc 2018 02 7 5 Results 1-10 of 10 1 Books Featured Books Dendrimer-based nanoformulations as drug carriers for cancer treatment. Advances in Polymeric Nanomaterials for Biomedical Applications, 137- 159. Amreddy N, Chinnappan M, Munshi A, Ramesh R (2020). Honors & Awards Abstract Scholarship Award for a poster presentation in American Thoracic Society, International Conference (2018) Professional Associations/Affiliations Department of Dermatology (2020)
