Michael Youssef, M.D. Assistant Professor School Medical School Department Neurology | Harold C. Simmons Comprehensive Cancer Center You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Clinical Interests: Dr. Youssef now sees patients with both low and high-grade gliomas, as well as other brain tumors including medulloblastoma, ependymoma, meningiomas, and rare brain tumors. He also sees patients with neurologic complications of systemic cancer therapy, brain metastasis, and leptomeningeal disease. Background: Dr. Youssef was born in Greenville, SC, and completed his undergraduate education at the University of Pittsburgh with a major in Neuroscience. He completed his medical education at the Medical University of South Carolina (MUSC) where he furthered his neurology education with several research projects, winning a grant from the American Brain Tumor Association to study glioblastoma both molecularly and radiographically. After completing medical school he completed his residency in Houston, TX at Baylor College of Medicine in the Department of Neurology. He continued to perform research on high-grade gliomas, as well as low-grade gliomas while in residency. This then led to a fellowship at MD Anderson Cancer Center where he continued to learn neuro-oncology and continue to work on several research projects that have been presented at multiple national meetings and published in several medical journals. Education Medical School Medical University of South Carolina (2014) Residency Baylor College of Medicine (2018), Neurology Fellowship MD Anderson Cancer Center (2020), Neuro-oncology Research Interest Cancer Neurology Glioblastoma Low grade gliomas Rare brain tumors Publications Extraneural metastatic ependymoma: Distant metastasis to the pleura, lungs, lymph nodes and bone Guirguis M, Jiang Z, Cai C, Youssef M BMJ Case Reports 2024 May 17 The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy Kumthekar PU, Blouw B, Corkos P, Nagpal S, Tripathy A, Piccioni D, Youssef M Frontiers in Oncology 2024 14 Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas Hsu EJ, Thomas J, Maher EA, Youssef M, Timmerman RD, Wardak Z, Dan TD, Patel TR, Vo D Discover Oncology 2022 Dec 13 Neutrophilia and post-radiation thrombocytopenia predict for poor prognosis in radiation-treated glioma patients Hsu EJ, Thomas J, Maher EA, Youssef M, Timmerman RD, Wardak Z, Lee M, Dan TD, Patel TR, Vo D Frontiers in Oncology 2022 Sep 12 EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation Guo G, Gong K, Beckley N, Zhang Y, Yang X, Chkheidze R, Hatanpaa KJ, Garzon-Muvdi T, Koduru P, Nayab A, Jenks J, Sathe AA, Liu Y, Xing C, Wu SY, Chiang CM, Mukherjee B, Burma S, Wohlfeld B, Patel T, Mickey B, Abdullah K, Youssef M, Pan E, Gerber DE, Tian S, Sarkaria JN, McBrayer SK, Zhao D, Habib AA Nature cell biology 2022 Aug 24 1291-1305 Metabolic and nutritional nervous system dysfunction in cancer patients Youssef MN, Beal T, Mandel J 2022 Jan 179-194 Distance traveled to glioblastoma treatment: A measure of the impact of socioeconomic status on survival Bird CE, Traylor JI, Youssef M, Abdullah K Clinical Neurology and Neurosurgery 2021 Oct 209 IDH mutation status and the development of venous thromboembolism in astrocytoma patients Mandel JJ, Youssef M, Yust-Katz S, Patel AJ, Jalali A, Li Z, Wu J, Ludmir EB, de Groot JF Journal of the Neurological Sciences 2021 Aug 427 Paraneoplastic syndromes in small cell lung cancer Soomro Z, Youssef M, Yust-Katz S, Jalali A, Patel AJ, Mandel J Journal of Thoracic Disease 2020 Oct 12 6253-6263 Treatment strategies for glioblastoma in older patients: age is just a number Youssef M, Ludmir EB, Mandel JJ, Patel AJ, Jalali A, Treiber J, Wu J, McAleer MF, de Groot JF Journal of Neuro-Oncology 2019 Nov 145 357-364 Results 1-10 of 17 1 2 Next Last Books Featured Books Metabolic and Nutritional Nervous System Dysfunction in Cancer Patients. In Neurological Complications of Systemic Cancer and Antineoplastic Therapy, Second Edition Youssef M, Beal T, Mandel J (2020). Newton/Malkin Recent Advances for Targeted Therapies in Glioblastoma. In Advances in Biology and Treatment of Glioblastoma Youssef M., Mandel J., Chowdhary S., Kesari S. (2017). Springer Honors & Awards Chief Fellow, MD Anderson Cancer Center Department of Neuro-Oncology (2019-2020) American Brain Tumor Association, Summer research grant recipiantResearch performed on GBM imaging and response to Temozolomide in patients exposed to O6-BG (2011-2011) Professional Associations/Affiliations American Academy of Neurology (2014) Society for Neuro-Oncology (2018)
