Sisi Zheng, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center and a member of the Division of Pediatric Hematology and Oncology. She joined the faculty at UT Southwestern in 2021.


Dr. Zheng received her bachelor’s degree in molecular biology at the University of Pennsylvania. She then earned her medical degree at Weill Cornell Medical College and subsequently completed her pediatric residency and fellowship training in pediatric hematology-oncology at the Children’s Hospital of Philadelphia. During her fellowship, her research led to the characterization of aberrant splice isoforms that are important to drug resistance against CD22-based immunotherapies.


Dr. Zheng’s laboratory research focuses on understanding how inflammation in the bone marrow environment can facilitate the outgrowth of clonally mutated hematopoietic stem cells (HSCs) and contribute to the early development of myeloid leukemias.


Dr. Zheng’s clinical interest is in the care of patients in need of bone marrow transplants for malignant and non-malignant diseases.


Dr. Zheng is a member of the American Academy of Pediatrics, Children’s Oncology Group, American Society of Hematology, and American Association of Cancer Research.


Medical School
Weill Cornell Medicine (2014)
Children's Hospital of Philadelphia (2017), Pediatrics
Children's Hospital of Philadelphia (2020), Pediatric Hematology/oncology

Research Interest

  • Bone marrow environment
  • Clonal hematopoiesis
  • Immunology and Host defenses
  • Leukemia
  • Retrotransposons