Noelle Williams, Ph.D. Professor School Medical School Department Biochemistry Graduate Programs Biological Chemistry Education Undergraduate Trinity University (1990), Biology Graduate School University of Virginia Main Ca (1996), Microbiology Research Interest pharmacokinetics small molecule therapeutics toxicology Publications Featured Publications Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair. Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM J. Med. Chem. 2017 Apr Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D Science 2017 Mar Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT J. Med. Chem. 2017 Jan Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D Nat. Chem. Biol. 2016 Feb A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma Sivanand S, Peña-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J. Sci. Transl. Med. 2012 4 137 137ra75 Development of proneurogenic, neuroprotective small molecules. MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM J. Am. Chem. Soc. 2011 Feb 133 5 1428-37 Targeting QseC signaling and virulence for antibiotic development Rasko, DA, CG Moreira, DR Li, NC Reading, JM Ritchie, MK Waldor, N Williams, R Taussig, S Wei, M Roth, DT Hughes, JF Huntley, MW Fina, JR Falck, and V Sperandio Science August 2008 321 1078-1080 (-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia. Voorhees JR, Remy MT, Cintrón-Pérez CJ, El Rassi E, Khan MZ, Dutca LM, Yin TC, McDaniel LN, Williams NS, Brat DJ, Pieper AA Biol. Psychiatry 2017 Nov Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma. Eskiocak B, McMillan E, Mendiratta S, Kollipara R, Zhang H, Humphries C, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales T, Eskiocak U, Smith MP, Sudderth J, Komurov K, DeBerardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White M Cancer Discov 2017 Apr Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion. Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF MBio 2017 Apr 8 2 Results 1-10 of 72 1 2 3 4 5 Next Last Honors & Awards Young Investigator AwardAmerican Cancer Society/Simmons Cancer Center, UTSW (2002) Individual National Research Service AwardNational Cancer Institute (1998) Postdoctoral FellowshipLeukemia Research Foundation (1997) Professional Associations/Affiliations American Association for Cancer Research (2006) American Society for Mass Spectrometry (2016) American Society for Pharmacology and Experimental Therapeutics (2006) International Society for the Study of Xenobiotics (2012)
