Emina Huang, M.D.

Professor

Endowed Title: Doyle L. Sharp, M.D. Distinguished Chair in Surgical Research
School: Graduate School
Department: Surgery | Biomedical Engineering | Harold C. Simmons Comprehensive Cancer Center
Graduate Programs: Biomedical Engineering, Cancer Biology

You have reached the Academic Profile.

For more information on the doctor and patient care, please visit the clinical profile.

Biography

Emina Huang, M.D., is the executive vice-chair of research. She is a world-class researcher and clinician from the Cleveland Clinic Lerner College of Medicine, where she served as a professor of surgery.

Dr. Huang is a graduate of the Stanford University School of Medicine, performed a residency in general surgery at the Ohio State University, and completed a colorectal surgery fellowship at Grant Medical Center in Columbus, Ohio. In addition to her clinical training, Dr. Huang has also earned a master’s degree in business administration from the Case Western Reserve Weatherhead School of Management.

Dr. Huang is a nationally and internationally renowned surgical scientist. Her research findings in colorectal cancer genesis have been published in high-impact journals such as Nature Communications and Nature Biotechnology, and she has had consistent NIH funding over the past two decades.

In her role as executive vice-chair of research, she oversees a rapidly expanding portfolio of intramural- and extramural-funded research that spans the clinical, health services, and basic and translational science domains. As a faculty member in the Division of Colon & Rectal Surgery, Dr. Huang provides cutting-edge colorectal care at the Parkland Health & Hospital System. She specializes in treating benign and colorectal diseases and can receive referrals at the multidisciplinary colorectal clinic at Parkland.

Education

Medical School: Stanford University School of Medicine (1989)
Research Fellowship: Ohio State University Hospital (1995), Transplant Surgery
Residency: Ohio State University Hospital (1997), General Surgery
Fellowship: Grant Medical Center (1998), Colon & Rectal Surgery

Publications

Featured Publications

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer.: Huning NC, Buhaya MH, Nguyen VV, Khazi-Syed A, Ali HA, Khan A, Fan A, Fisher RC, Chi Z, Raman I, Chen G, Zhu C, Yu M, Jamieson AR, Roccabianca S, Varner VD, Lewis CM, Huang EH, Ferruzzi J, bioRxiv 2025 Jul
Appraising a CREATEive Surgeon-Scientist Initiative: Impact and Future Directions.: Neylan CJ, Bercz A, Regenbogen SE, Huang EH, Smith JJ, Maguire LH, Mitchem JB, Dis Colon Rectum 2025 Jun 68 6 656-657
Disparities in Colorectal Cancer Presentation at a National Cancer Institute-Designated Cancer Center and a Safety-Net Hospital during the COVID-19 Pandemic.: Buhaya MH, Turley M, Negrete Vasquez O, Bryant N, Jafry B, Chilakamarry S, Pogacnik JS, Kazmi SM, Su J, Huang EH, Med Res Arch 2024 Aug 12 8
GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.: Rana N, Privitera G, Kondolf HC, Bulek K, Lechuga S, De Salvo C, Corridoni D, Antanaviciute A, Maywald RL, Hurtado AM, Zhao J, Huang EH, Li X, Chan ER, Simmons A, Bamias G, Abbott DW, Heaney JD, Ivanov AI, Pizarro TT, Cell 2024 Feb 187 4 1011-1015
Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.: Sarvestani SK, Signs S, Hu B, Yeu Y, Feng H, Ni Y, Hill DR, Fisher RC, Ferrandon S, DeHaan RK, Stiene J, Cruise M, Hwang TH, Shen X, Spence JR, Huang EH, Nat Commun 2021 01 12 1 262
Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells.: Fisher RC, Bellamkonda K, Alex Molina L, Xiang S, Liska D, Sarvestani SK, Chakrabarti S, Berg A, Jorgensen ML, Hatala D, Chen S, Aiello A, Appelman HD, Scott EW, Huang EH, Neoplasia 2019 03 21 3 269-281
Stromal miR-20a controls paracrine CXCL8 secretion in colitis and colon cancer.: Signs SA, Fisher RC, Tran U, Chakrabarti S, Sarvestani SK, Xiang S, Liska D, Roche V, Lai W, Gittleman HR, Wessely O, Huang EH, Oncotarget 2018 Feb 9 16 13048-13059
CDX2: Linking Cell and Patient Fates in Colon Cancer.: Fearon ER, Huang EH, Cell Stem Cell 2016 02 18 2 168-9
Transition from colitis to cancer: high Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors.: Shenoy AK, Fisher RC, Butterworth EA, Pi L, Chang LJ, Appelman HD, Chang M, Scott EW, Huang EH, Cancer Res 2012 Oct 72 19 5091-100
Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer.: Carpentino JE, Hynes MJ, Appelman HD, Zheng T, Steindler DA, Scott EW, Huang EH, Cancer Res 2009 Oct 69 20 8208-15