Dr. Hans-Christian Reinecker received his M.D. from the Christian Albrecht’s University, Kiel, Germany and completed his post-doctoral training at the University of Pennsylvania with Dr. Richard McDermott, and with Dr. Daniel K. Podolsky at the Massachusetts General Hospital and Harvard Medical School. Dr. Reinecker is internationally recognized as a cell/molecular biologist in the field of innate and adaptive immune responses involved in the pathogenesis of chronic inflammatory diseases and autoimmunity. The Reinecker laboratory currently focuses on the role of the intracellular and microtubule based immune recognition pathways for host defense responses against pathogens and in anti-tumor immunity. He is also involved in studies aimed at translating fundamental understanding of these processes into new therapies for IBD, cancer and autoimmune diseases. Dr. Reinecker’s goal is to establish an advanced scientific program in mucosal immunology and anti-tumor immunity by fostering the education of basic and clinical researchers for a commitment to excellence and innovation in patient care.

Research Interest

  • Control of adaptive host-defenses by Schlafen family proteins.
  • Controlling innate and adaptive immune responses by Sensor Stimulator of Interferon Genes (STING).
  • Developing strategies to induce anti-tumor immunity for cancer immunotherapy.
  • Targeting intracellular microtubule based microbial pattern recognition to control disease mechanisms of Inflammatory Bowel Diseases.


Featured Publications LegendFeatured Publications

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses.
Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, Martin K, Sharma A, Olieric N, Shah P, Stanczak M, Kirchhammer N, Park SM, Wieckowski S, Laubli H, Zagani R, Kasenda B, Steinmetz MO, Reinecker HC, Zippelius A, Cell Rep 2019 Sep 28 13 3367-3380.e8
Microbial recognition by GEF-H1 controls IKKe mediated activation of IRF5.
Zhao Y, Zagani R, Park SM, Yoshida N, Shah P, Reinecker HC, Nat Commun 2019 03 10 1 1349
T Cells Control Intestinal IgA Production.
Kim YI, Song JH, Ko HJ, Kweon MN, Kang CY, Reinecker HC, Chang SY J. Immunol. 2018 Jul
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ, Science 2018 03 359 6380 1161-1166
Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation.
Maldonado-Contreras A, Birtley JR, Boll E, Zhao Y, Mumy KL, Toscano J, Ayehunie S, Reinecker HC, Stern LJ, McCormick BA, Gut Microbes 2017 11 8 6 544-560
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B Science 2017 Apr 356 6333 44-50
Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells.
Li Y, Basavappa M, Lu J, Dong S, Cronkite DA, Prior JT, Reinecker HC, Hertzog P, Han Y, Li WX, Cheloufi S, Karginov FV, Ding SW, Jeffrey KL Nat Microbiol 2016 Dec 2 16250


Featured Books Legend Featured Books

Honors & Awards

  • Postgraduate Research Award
    Alumni Association of the Lahey Clinic Foundation (1994)
  • Inflammatory Bowel Disease Young Investigator Award
    Crohn's & Colitis Foundation of America (1993)

Professional Associations/Affiliations

  • American Association of Immunologists (1998)
  • American Gastroenterological Association (1995)