Dr. Hans-Christian Reinecker received his M.D. from the Christian Albrecht’s University, Kiel, Germany and completed his post-doctoral training at the University of Pennsylvania with Dr. Richard McDermott, and with Dr. Daniel K. Podolsky at the Massachusetts General Hospital and Harvard Medical School. Dr. Reinecker is internationally recognized as a cell/molecular biologist in the field of innate and adaptive immune responses involved in the pathogenesis of chronic inflammatory diseases and autoimmunity. The Reinecker laboratory currently focuses on the role of the intracellular and microtubule based immune recognition pathways for host defense responses against pathogens and in anti-tumor immunity. He is also involved in studies aimed at translating fundamental understanding of these processes into new therapies for IBD, cancer and autoimmune diseases. Dr. Reinecker’s goal is to establish an advanced scientific program in mucosal immunology and anti-tumor immunity by fostering the education of basic and clinical researchers for a commitment to excellence and innovation in patient care.

Research Interest

  • Control of adaptive host-defenses by Schlafen family proteins.
  • Controlling innate and adaptive immune responses by Sensor Stimulator of Interferon Genes (STING).
  • Developing strategies to induce anti-tumor immunity for cancer immunotherapy.
  • Targeting intracellular microtubule based microbial pattern recognition to control disease mechanisms of Inflammatory Bowel Diseases.


Featured Publications LegendFeatured Publications

Vascular Patterning as Integrative Readout of Complex Molecular and Physiological Signaling by VESsel GENeration Analysis.
Lagatuz M, Vyas RJ, Predovic M, Lim S, Jacobs N, Martinho M, Valizadegan H, Kao D, Oza N, Theriot CA, Zanello SB, Taibbi G, Vizzeri G, Dupont M, Grant MB, Lindner DJ, Reinecker HC, Pinhas A, Chui TY, Rosen RB, Moldovan N, Vickerman MB, Radhakrishnan K, Parsons-Wingerter P, J Vasc Res 2021 Apr 1-24
The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells.
Yousif AS, Ronsard L, Shah P, Omatsu T, Sangesland M, Bracamonte Moreno T, Lam EC, Vrbanac VD, Balazs AB, Reinecker HC, Lingwood D, Immunity 2021 02 54 2 235-246.e5
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.
Luther J, Khan S, Gala MK, Kedrin D, Sridharan G, Goodman RP, Garber JJ, Masia R, Diagacomo E, Adams D, King KR, Piaker S, Reinecker HC, Yarmush ML, Argemi J, Bataller R, Dienstag JL, Chung RT, Patel SJ, Proc Natl Acad Sci U S A 2020 05 117 21 11667-11673
Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling
Klare L. Bersch, Kristen E. DeMeester, Rachid Zagani, Kimberly A. Wodzanowski, Hans-Christian Reinecker, Catherine L. Grimes 2020
T Cells Control Intestinal IgA Production.
Kim YI, Song JH, Ko HJ, Kweon MN, Kang CY, Reinecker HC, Chang SY J. Immunol. 2018 Jul
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ, Science 2018 03 359 6380 1161-1166


Featured Books Legend Featured Books

Honors & Awards

  • Postgraduate Research Award
    Alumni Association of the Lahey Clinic Foundation (1994)
  • Inflammatory Bowel Disease Young Investigator Award
    Crohn's & Colitis Foundation of America (1993)

Professional Associations/Affiliations

  • American Association of Immunologists (1998)
  • American Gastroenterological Association (1995)