Hans-Christian Reinecker, M.D. Associate Professor School Medical School Department Internal Medicine | Center for Genetics of Host Defense | Immunology Graduate Programs Immunology Biography Hans-Christian Reinecker, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Digestive and Liver Diseases. He has a secondary appointment in the Center for the Genetics of Host Defense and a tertiary appointment in the Department of Immunology. Dr. Reinecker earned his medical degree at Christian Albrecht's University in Kiel, Germany. He completed internal medicine residency training at Altonaer Children's Hospital in Hamburg, Germany, followed by an advanced fellowship in gastroenterology at the University of Hamburg. He completed a postdoctoral fellowship at the University of Pennsylvania and a second postdoctoral fellowship at Harvard Medical School. Dr. Reinecker joined the UT Southwestern faculty in 2020 after working at Harvard Medical School and Massachusetts General Hospital since 1995. Research Interest Control of adaptive host-defenses by Schlafen family proteins. Controlling innate and adaptive immune responses by Sensor Stimulator of Interferon Genes (STING). Developing strategies to induce anti-tumor immunity for cancer immunotherapy. Targeting intracellular microtubule based microbial pattern recognition to control disease mechanisms of Inflammatory Bowel Diseases. Publications Featured Publications Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling. Bersch KL, DeMeester KE, Zagani R, Chen S, Wodzanowski KA, Liu S, Mashayekh S, Reinecker HC, Grimes CL, ACS Cent Sci 2021 Apr 7 4 688-696 GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, Martin K, Sharma A, Olieric N, Shah P, Stanczak M, Kirchhammer N, Park SM, Wieckowski S, Laubli H, Zagani R, Kasenda B, Steinmetz MO, Reinecker HC, Zippelius A, Cell Rep 2019 Sep 28 13 3367-3380.e8 Microbial recognition by GEF-H1 controls IKKe mediated activation of IRF5. Zhao Y, Zagani R, Park SM, Yoshida N, Shah P, Reinecker HC, Nat Commun 2019 03 10 1 1349 T cell fate following Salmonella infection is determined by a STING-IRF1 signaling axis in mice. Park SM, Omatsu T, Zhao Y, Yoshida N, Shah P, Zagani R, Reinecker HC, Commun Biol 2019 2 464 Vascular Patterning as Integrative Readout of Complex Molecular and Physiological Signaling by VESsel GENeration Analysis. Lagatuz M, Vyas RJ, Predovic M, Lim S, Jacobs N, Martinho M, Valizadegan H, Kao D, Oza N, Theriot CA, Zanello SB, Taibbi G, Vizzeri G, Dupont M, Grant MB, Lindner DJ, Reinecker HC, Pinhas A, Chui TY, Rosen RB, Moldovan N, Vickerman MB, Radhakrishnan K, Parsons-Wingerter P, J Vasc Res 2021 Apr 1-24 The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells. Yousif AS, Ronsard L, Shah P, Omatsu T, Sangesland M, Bracamonte Moreno T, Lam EC, Vrbanac VD, Balazs AB, Reinecker HC, Lingwood D, Immunity 2021 02 54 2 235-246.e5 Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Luther J, Khan S, Gala MK, Kedrin D, Sridharan G, Goodman RP, Garber JJ, Masia R, Diagacomo E, Adams D, King KR, Piaker S, Reinecker HC, Yarmush ML, Argemi J, Bataller R, Dienstag JL, Chung RT, Patel SJ, Proc Natl Acad Sci U S A 2020 05 117 21 11667-11673 Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling Klare L. Bersch, Kristen E. DeMeester, Rachid Zagani, Kimberly A. Wodzanowski, Hans-Christian Reinecker, Catherine L. Grimes 2020 T Cells Control Intestinal IgA Production. Kim YI, Song JH, Ko HJ, Kweon MN, Kang CY, Reinecker HC, Chang SY J. Immunol. 2018 Jul C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ, Science 2018 03 359 6380 1161-1166 Results 1-10 of 74 1 2 3 4 5 Next Last Books Featured Books Pathways for the recognition of the intestinal microbiota. In Bioscience Microflora Reinecker HC (2006). Dendritic Cells in the recognition of intestinal microbiota. In Cellular Microbiology Niess JH, Reinecker HC (2006). Lamina Propria dendritic cells in physiology and pathology of the gastrointestinal tract. In Current Opinions in Gastroenterology Niess JH, Reinecker HC (2005). Chemokines in immune surveillance of the intestine. In Chemokines, Chemokine Receptors, and Disease Niess JH, Reinecker, HC (2005). San Diego, CA, Elsevier Academic Press Dendritic Cells: The commanders-in-chief of mucosal immune defenses. In Current Opinions in Gastroenterology Niess JH, Reinecker, HC (2006). Honors & Awards Postgraduate Research AwardAlumni Association of the Lahey Clinic Foundation (1994) Inflammatory Bowel Disease Young Investigator AwardCrohn's & Colitis Foundation of America (1993) Professional Associations/Affiliations American Association of Immunologists (1998) American Gastroenterological Association (1995)
