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Elan Louis, M.D.,  M.S.

Elan Louis, M.D., M.S.

Titles and Appointments

Department of Neurology, Chair

Professor & Chair

Endowed Title
Linda and Mitch Hart Distinguished Chair in Neurology
Schools
Medical School
Departments
Neurology | Public Health

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Joined UT Southwestern: 2020

    Elan Louis, M.D., is Professor and Chair of the Department of Neurology at UT Southwestern Medical Center. He specializes in disorders of involuntary movement and is considered the world’s leading scholar in essential tremor (ET).

    Dr. Louis earned his medical degree at Yale University and a master’s degree in epidemiology at Columbia University. He completed a residency in neurology at Columbia-Presbyterian Medical Center and then received advanced training in movement disorders and neuroepidemiology through fellowships at Columbia University.

    Dr. Louis served in Yale University’s Department of Neurology from 2015 to 2020 as a tenured Professor of Neurology and Epidemiology, Chief of the Movement Disorders Division, Associate Chair of Outpatient Clinical Research, and Co-Director of the Center for Neuroepidemiology and Clinical Neurological Research. Prior to that, he was a tenured Professor of Neurology and Epidemiology at Columbia University’s College of Physicians and Surgeons, where he was also the Associate Chairman for Academic Affairs and Faculty Development.

    Certified by the American Board of Psychiatry and Neurology, Dr. Louis joined the UT Southwestern faculty in 2020.

    Dr. Louis’s research focuses on the genetics, epidemiology, and pathophysiology of tremor disorders. His work on essential tremors has been cited in the New York Times as “pioneering,” and, in fact, his research has challenged many of the prevailing notions about ET and has substantially recreated the dialogue in the ET field. He collaborates with investigators in Spain, Turkey, Mexico, and other countries, examining the epidemiology of ET in these populations.

    Dr. Louis established the Essential Tremor Centralized Brain Repository – a national centralized brain bank for the study of ET. He has received continuous funding from the National Institutes of Health (NIH) since 1995 and continuous R01 funding since 2000, as well as funding from the International Essential Tremor Foundation, the Charles A. Dana Foundation, the Parkinson's Disease Foundation, and a Paul Beeson Physician Faculty Scholars Award from the American Federation for Aging Research.

    He has authored more than 700 peer-reviewed scientific articles and book chapters and written invited editorials and reviews for Annals of Neurology, New England Journal of Medicine, and Lancet Neurology. He is the founding Editor-in-Chief of Tremor and Other Hyperkinetic Movements, and he serves on the editorial board of more than 10 other scholarly journals  He is also the editor of Merritt’s Textbook of Neurology, one of the premier general neurology textbooks in the country.

    Dr. Louis has served on multiple medical advisory boards, including the boards of the International Essential Tremor Foundation, the Tremor Action Network, and HopeNET, and he is a member of the American Academy of Neurology, the American Neurological Association, and the International Parkinson and Movement Disorder Society.

    He is committed to the care of patients with involuntary movements and has been listed by Castle Connolly as one of the Top Doctors in the field of Neurology.

  • Education
    Medical School
    Yale University School of Medicine (1989)
    Internship
    Yale University School of Medicine (1990), Internal Medicine
    Residency
    Columbia University, New York Presbyterian Hospital (1993), Neurology
    Fellowship
    Columbia University, New York Presbyterian Hospital (1995), Movement Disorders
    Other Post Graduate Training
    Harlem Hospital Center (1995), Epidemiology
    Fellowship
    Columbia University, New York Presbyterian Hospital (1995), Neuro-epidemiology
  • Research Interest
    • Disorders of involuntary movement
    • History of Science
    • Neurodegenerative diseases
    • Tremor disorders - associated comorbidities
    • Tremor disorders - clinical features
    • Tremor disorders - cohort studies
    • Tremor disorders - environmental determinants
    • Tremor disorders - epidemiology
    • Tremor disorders - genetic determinants
    • Tremor disorders - neuropathological and molecular basis
    • Tremor disorders - rating scales
  • Publications
    Comparative study of the pathology in anterior versus posterior hemispheric regions of cerebellum in essential tremor and controls
    Musacchio-Perrucci JB, Martuscello RT, Betzios SI, Hernandez RS, Kuo SH, Cosentino S, Fujita H, Louis ED, Faust PL Acta Neuropathologica 2026 Jun 151
    Essential Tremor Cases with Subtle Cerebellar Pathology: A Systematic Study of Postmortem Cerebellar Changes
    Betzios SI, Hernandez RS, Faust PL, Louis ED Cerebellum 2026 Apr 25
    Degenerative Changes in the Essential Tremor Cerebellum
    Louis ED, Faust PL Movement Disorders 2026 Feb 41 549-550
    Blood-based Alzheimer's disease biomarkers and cognitive decline in essential tremor
    Guy TO, Ghanem A, Berry DS, Hernandez NC, Sharma VD, Chapman S, Cosentino S, Louis ED Journal of Alzheimer's Disease 2026 Feb 109 1232-1241
    Predictors of Mortality in a Large Cohort of Elders with Essential Tremor
    Carter ED, Berry DS, Cosentino S, Louis ED Neuroepidemiology 2026 Feb 60 69-78
    Effects of surgical therapies on cognitive function in patients with essential tremor
    Sharma VD, Berry DS, Cosentino S, Louis ED Journal of the Neurological Sciences 2026 Jan 480
    Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period
    Kerridge CA, Hernandez RS, Hernandez NC, Faust PL, Louis ED Annals of Clinical and Translational Neurology 2026 Jan 13 36-48
    Does the Severity of Arm Tremor in Essential Tremor Correlate with Impaired Balance?
    Louis ED, Berry D Tremor and Other Hyperkinetic Movements 2026 16
    Emerging Noninvasive Approaches for the Suppression of Pathological Tremor
    Montero-Pardo C, Rocon E, Dosen S, Dideriksen JL, Gutiérrez Á, Pérez-Sánchez JR, Luque-Buzo E, Louis ED, Grandas F, Oliveira-Barroso F IEEE Reviews in Biomedical Engineering 2026 19 65-85
    Update on Essential Tremor
    Louis ED Seminars in Neurology 2026
  • Books

    Featured 

  • Honors & Awards
    • H. Richard Tyler Award historical research
      American Academy of Neurology (2010)
    • Lawrence C. McHenry Award for excellence in research in neurological history
      American Academy of Neurology (2010)
    • Dorothy Dillon Eweson Lectureship on Advances in Aging Research
      American Federation for Aging Research (2000-2005)
    • Paul Beeson Physician Faculty Scholar
      American Federation for Aging Research (1997-2000)
    • Lawrence C. McHenry Award for excellence in research in neurological history
      American Academy of Neurology (1994)
    • Outstanding Houseofficer and Teacher
      College of Physicians and Surgeons, Columbia University (1992)
    • Cum Laude
      Yale University School of Medicine (1989)
    • Harold Lamport Biomedical Research Prize
      Yale University School of Medicine (1989)
    • Merck Research Award
      Yale University School of Medicine (1989)
    • Magna Cum Laude
      University of Pennsylvania (1984)
    • Phi Beta Kappa
      University of Pennsylvania (1984)
  • Professional Associations/Affiliations
    • American Academy of Neurology (Scientific Program Subcomittee) (2002-2005)
    • Basal Ganglia (editorial board) (2017-2019)
    • Cerebellum and Ataxias (editorial board) (2014-2020)
    • Dystonia Medical Research Foundation (Medical Advisory Board) (2004-2006)
    • Frontiers in Movement Disorders (editorial board) (2010-2020)
    • HopeNET (Medical Advisory Board) (2014-2020)
    • Institute of Medicine (Committee to Review the Health Effects in Vietnam Veterans Exposed to Herbicides - Tenth Biennial Update) (2014-2015)
    • International Essential Tremor Foundation (Advisor) (2005-2020)
    • Journal of Clinical Movement Disorders (editorial board) (2013-2020)
    • Journal of the History of the Neurosciences (editorial board) (2001-2020)
    • Movement Disorders (editorial board) (2000-2005)
    • National Institutes of Health (Clinical Neuroscience and Disease Study Section Member) (2003-2008)
    • Neuroepidemiology (editorial board) (2008-2020)
    • Parkinson's Disease (editorial board) (2009-2020)
    • Tremor and Other Hyperkinetic Movements (Editor in Chief) (2010-2020)