Jason Fleming, M.D.

Jason B. Fleming, M.D., is a Professor in the Department of Surgery at UT Southwestern Medical Center. He is an internationally recognized surgical oncologist specializing in pancreatic cancer and serves as Deputy Director for Clinical Affairs of the Harold C. Simmons Comprehensive Cancer Center.

Dr. Fleming earned his medical degree at the University of Tennessee Center of Health Science. He completed a clinical residency in general surgery and a research fellowship in cancer research at UT Southwestern and the Hamon Center for Therapeutic Oncology Research. He also completed a clinical fellowship in surgical oncology at the University of Texas MD Anderson Cancer Center.

Certified by the American Board of Surgery, he rejoined the UT Southwestern faculty in 2024. He previously spent six years as an Assistant and Associate Professor in UT Southwestern’s Department of Surgery, from 1999 to 2006 . Before his return to UT Southwestern, Dr. Fleming served as a Professor of Surgical Oncology and Chief of Pancreas Surgery at MD Anderson and then as Chair of the Department of Gastrointestinal Oncology at the Moffitt Cancer Center in Tampa, Florida.

At UT Southwestern, Dr. Fleming directs all clinical operations at the Simmons Comprehensive Cancer Center (SCCC) and drives strategies to advance innovative, patient-centered cancer care across the health system. His goal is to promote and further establish SCCC as a national leader in multidisciplinary, evidence-based patient care, cancer clinical trials, and novel treatment approaches.

He is a prolific academician, with over 300 peer-reviewed publications and contributions to numerous books. He has delivered many international, national, and regional invited lectures. He serves as principal investigator or co-investigator for numerous active research projects, with grant support from sources such as the National Institutes of Health, the National Cancer Institute, and the U.S. Army Medical Research Acquisition Activity’s Pancreatic Cancer Research Program.

Dr. Fleming is a Fellow of the American College of Surgeons and a member of numerous other professional organizations, including the American Society of Clinical Oncology, the Society of Surgical Oncology, and the American Association for Cancer Research. He also serves on the editorial board for the journal Surgery Open Science and serves as an ad hoc reviewer for several other scholarly journals.

The recipient of numerous awards, he has been named a Castle Connolly Top Doctor every year since 2013.

When he’s not at work, Dr. Fleming is an avid reader of history and is learning game design. Most importantly, he enjoys spending time with friends and family.

Medical School

University of Tennessee Health Science Center (1990)

Internship

UT Southwestern Medical Center (1991)

Research Fellowship

UT Southwestern Medical Center (1995), Surgical Oncology

Residency

UT Southwestern Medical Center (1997), General Surgery

Fellowship

UT MD Anderson Cancer Center (1999)

• Pancreatic Cancer

 Featured Books

Current issues of borderline resectable pancreatic ductal adenocarcinoma. In Pancreatic Cancer, With Special Focus on Topical Issues and Surgical Techniques

Denbo JW, Fleming JB (2017). Berlin, Springer-Verlag

Definition and management of borderline resectable pancreatic cancer. In Pancreatic Cancer and Periampullary Neoplasms

Denbo JW, Fleming JB (2016). Philadelphia,, Elsevier

Molecular and genetic basis of pancreatic carcinogenesis: Which concepts may be clinically relevant. In Pancreatic Neoplasms

Bernard V, Fleming JB, Maitra A (2016). Philadelphia, Elsevier

Pancreatic cancer (exocrine). In 60 Years of Survival Outcomes at The University of Texas MD Anderson Cancer Center

Fleming JB, Katz M, Hwang R, Varadhachary G (2013). New York, Springer

Patient-derived xenograft model of pancreatic cancer. In Patient Derived Tumor Xenograft Models

Rios Perez MV, Fleming JB (2016). United Kingdom, Elsevier

Complex General Surgical Oncology: A Case-Based Approach

Abbott DE, Fleming JB (2014). London, Future Medicine Ltd

Cystic pancreatic lesions. In Oncologic Imaging: A Multidisciplinary Approach

Bhosale P, Fleming JB, Das P, Javle M, Lee JH (2012). Philadelphia, Elsevier

Pancreatic ductal adenocarcinoma. In Oncologic Imaging: A Multidisciplinary Approach

Tamm EP, Fleming JB, Varadhachary GR (2012). Philadelphia, Elsevier

Imaging of pancreatic adenocarcinoma: Update on staging/resectability. In Pancreatic Imaging, Radiologic Clinics of North America

Tamm EP, Balachandran A, Bhosale PR, Katz MH, Fleming JB, Lee JH, Varadhachary GR (2012). Saunders

Surgical management of sporadic gastrointestinal neuroendocrine tumors. In Neuroendocrine Tumors

Callender GG, Fleming JB (2011). New York, Springer

Borderline resectable pancreatic adenocarcinoma. In Pancreatic Cancer

Katz MHG, Fleming JB, Lee JE, Pisters PWT (2011). New Delhi, India, Elsevier

The recognition and surgical management of heritable lesions of the pancreas. In Surgical Oncology Clinics of North America

Kim MP, Evans DP, Vu TM, Fleming JB (2009). Philadelphia, W.B. Saunders

Advanced therapy in surgical oncology. In Gastric Cancer Chapter

Fleming JB (2008). BC Decker Inc

Unusual pancreatic tumors. In Current Surgical Therapy

Phillips K, Fleming JB, Tamm EP, Evans DB (2008). Philadelphia, Mosby Elsevier

Laparoscopy in the evaluation of patients with upper gastrointestinal malignancies. In Laparoscopic Surgery: Principles and Procedures

Fleming JB (2001). Marcel Dekker

Pancreas in Selected Readings. In General Surgery

Fleming JB (2001).

Cell signaling pathways in pancreatic cancer. In M.D. Anderson Solid Tumor Oncology Series: Pancreatic Cancer

Fleming JB (2000). Springer-Verlag

Sarcoma and lymphoma. In Selected Readings in General Surgery

Fleming JB (2000).

General oncology. In Selected Readings in General Surgery

Fleming JB (1999).

Signal transduction pathways in pancreatic cancer. In Methods in Molecular Medicine: Molecular Biology of Pancreatic Cancer

Fleming JB, Breslin T, Evans D, Chiao P (1998). Humana Press

Collected letters in surgery. In Question No. 651: Papillary Thyroid Cancer in Pregnancy

Fleming JB, Evans D (1997).

Radiation injury. In The Parkland Trauma Handbook

Fleming JB (1994). CV Mosby

• Jack Kolosky Award
  Moffitt First Connect (2021)
• Moffitt Telly Award
  MCC 360 Patient Experience Video (2020)
• Best Doctors In America
  Best Doctors List (2019-2020)
• Induction
  American College of Surgeons Master Surgeon Educators (2019)
• Top Doctor
  International Association of HealthCare Professionals (2018)
• Castle Connolly Top Doctor
  American Registry, LLC and Castle Connolly Medical Ltd. (2013)
• Guide to America's Top Surgeons
  Consumer Research Council of America (2012)
• Texas Super Doctors
  Texas Monthly (2011)

• American Association for Cancer Research
• American College of Surgeons
• American Radium Society
• American Society of Clinical Oncology
• American Surgical Association
• Pancreas Club
• Society for Surgery of the Alimentary Tract
• Society of Surgical Oncology
• Society of University Surgeons
• Southern Surgical Society
• Western Surgical Society