Jason B. Fleming, M.D., is a Professor in the Department of Surgery at UT Southwestern Medical Center. He is an internationally recognized surgical oncologist specializing in pancreatic cancer and serves as Deputy Director for Clinical Affairs of the Harold C. Simmons Comprehensive Cancer Center.

Dr. Fleming earned his medical degree at the University of Tennessee Center of Health Science. He completed a clinical residency in general surgery and a research fellowship in cancer research at UT Southwestern and the Hamon Center for Therapeutic Oncology Research. He also completed a clinical fellowship in surgical oncology at the University of Texas MD Anderson Cancer Center.

Certified by the American Board of Surgery, he rejoined the UT Southwestern faculty in 2024. He previously spent six years as an Assistant and Associate Professor in UT Southwestern’s Department of Surgery, from 1999 to 2006 . Before his return to UT Southwestern, Dr. Fleming served as a Professor of Surgical Oncology and Chief of Pancreas Surgery at MD Anderson and then as Chair of the Department of Gastrointestinal Oncology at the Moffitt Cancer Center in Tampa, Florida.

At UT Southwestern, Dr. Fleming directs all clinical operations at the Simmons Comprehensive Cancer Center (SCCC) and drives strategies to advance innovative, patient-centered cancer care across the health system. His goal is to promote and further establish SCCC as a national leader in multidisciplinary, evidence-based patient care, cancer clinical trials, and novel treatment approaches.

He is a prolific academician, with over 300 peer-reviewed publications and contributions to numerous books. He has delivered many international, national, and regional invited lectures. He serves as principal investigator or co-investigator for numerous active research projects, with grant support from sources such as the National Institutes of Health, the National Cancer Institute, and the U.S. Army Medical Research Acquisition Activity’s Pancreatic Cancer Research Program.

Dr. Fleming is a Fellow of the American College of Surgeons and a member of numerous other professional organizations, including the American Society of Clinical Oncology, the Society of Surgical Oncology, and the American Association for Cancer Research. He also serves on the editorial board for the journal Surgery Open Science and serves as an ad hoc reviewer for several other scholarly journals.

The recipient of numerous awards, he has been named a Castle Connolly Top Doctor every year since 2013.

When he’s not at work, Dr. Fleming is an avid reader of history and is learning game design. Most importantly, he enjoys spending time with friends and family.



Medical School
University of Tennessee Health Science Center (1990)
UT Southwestern Medical Center (1991)
Research Fellowship
UT Southwestern Medical Center (1995), Surgical Oncology
UT Southwestern Medical Center (1997), General Surgery
UT MD Anderson Cancer Center (1999)

Research Interest

  • Pancreatic Cancer


Featured Books Legend Featured Books

Honors & Awards

  • Jack Kolosky Award
    Moffitt First Connect (2021)
  • Moffitt Telly Award
    MCC 360 Patient Experience Video (2020)
  • Best Doctors In America
    Best Doctors List (2019-2020)
  • Induction
    American College of Surgeons Master Surgeon Educators (2019)
  • Top Doctor
    International Association of HealthCare Professionals (2018)
  • Castle Connolly Top Doctor
    American Registry, LLC and Castle Connolly Medical Ltd. (2013)
  • Guide to America's Top Surgeons
    Consumer Research Council of America (2012)
  • Texas Super Doctors
    Texas Monthly (2011)

Professional Associations/Affiliations

  • American Association for Cancer Research
  • American College of Surgeons
  • American Radium Society
  • American Society of Clinical Oncology
  • American Surgical Association
  • Pancreas Club
  • Society for Surgery of the Alimentary Tract
  • Society of Surgical Oncology
  • Society of University Surgeons
  • Southern Surgical Society
  • Western Surgical Society