
Lorena Saelices Gomez, Ph.D.
Assistant Professor
Department Center for Alzheimer’s and Neurodegenerative Diseases | Biophysics
Graduate Programs Molecular Biophysics, Neuroscience
Biography
Dr. Saelices earned her B.S. in biology and her Ph.D. in biochemistry from the University of Seville, where her training focused on molecular biology and structural biology. She performed postdoctoral research at ETH Zürich and UCLA, and was an Assistant and Associate Project Scientist at UCLA, where she focused on protein aggregation to develop new potential therapeutic strategies for transthyretin amyloidosis and Alzheimer's disease.
She joined the UTSW faculty in 2020. Her lab applies crystallography and cryo-electron microscopy to obtain atomic information of amyloid structures, which is later used to design tools for the clinic. The lab's attention is mainly directed on transthyretin amyloidosis and Alzheimer’s disease.
Education
- Undergraduate
- University of Seville - Spain (2005), Biology
- Graduate School
- University of Seville - Spain (2007), Biochemistry
- Graduate School
- University of Seville - Spain (2010), Biochemistry
Research Interest
- Amyloid deposition
- Cardiac amyloidosis
- Cryo-electron microscopy
- Crystallography
- Rational and computational design
- Transthyretin amyloidosis
Publications
Featured Publications
- The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
- Cao Q, Anderson DH, Liang WY, Chou JA, Saelices L, J. Biol. Chem. 2020 Aug
- A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils.
- Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS J. Biol. Chem. 2019 Feb
- Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR.
- Saelices L, Pokrzywa M, Pawelek K, Eisenberg DS, Neurobiol. Dis. 2018 12 120 118-125
- Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.
- Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS, Proc. Natl. Acad. Sci. U.S.A. 2018 07 115 29 E6741-E6750
- Crystal structures of amyloidogenic segments of human transthyretin.
- Saelices L, Sievers SA, Sawaya MR, Eisenberg DS, Protein Sci. 2018 07 27 7 1295-1303
- Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
- Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS, J. Biol. Chem. 2018 02 293 8 2888-2902
- Uncovering the Mechanism of Aggregation of Human Transthyretin.
- Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS J. Biol. Chem. 2015 Oct
Books
Featured Books
Aproximación molecular al estudio del ciclo del nitrógeno en la biosfera y sus repercusiones agronómicas y medioambientales. In Avances en el metabolismo del nitrógeno
Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI (2011). Córdoba, Servicio de Publicaciones de la Univ. de Córdoba
Honors & Awards
- Distinguished Researcher Award, UTSW Presidents Research Council
(2021) - DP2 New Innovator Award. NIH-NHLBI
(2021) - Izasa Scientifica Award for Best Plenary Talk. CajalXmas Meeting
(2021) - FASEB NextGen Award
FASEB Protein Aggregation Conference (2019) - The Company of Biologists Small Meeting Grant
FASEB Next Generation Seminar (2019) - UCLA-DOE Scientific Productivity Award
(2019) - International Society of Amyloidosis Presidential Travel Award
(2018) - UCLA Clinical and Translational Science Institute Core Voucher Award
(2018) - David Seldin, MD, PhD Memorial Research Grant
The Amyloidosis Foundation (2017-2018) - Amyloidosis Foundation Research Grant
(2016) - Poster Presentation Prize
ISA International Symposium on Amyloidosis (2016) - Presidential Travel Award
International Society of Amyloidosis (2016) - The Company of Biologists Small Meeting Grant
Gordon Research Seminar on Neurobiology of Brain Disorders (2016) - Marie Curie Postdoctoral Fellowship
(2012-2015) - Training Fellowship (UCLA)
Ministry of Education, Culture and Sports, Spain (2009) - Training Research Fellowship (Institute for Biomedicine, Valencia)
Ministry of Education, Culture and Sports, Spain (2009) - Pre-doctoral Fellowship
Ministry of Education, Culture and Sports, Spain (2006) - Undergraduate Research Training Fellowship
Ministry of Education, Culture and Sports, Spain (2004) - Undergraduate Studies Scholarship
Ministry of Education, Culture and Sports, Spain (2001-2005)