Hume Stroud received his B.A. from Cornell University. He completed his Ph.D. at the University of California, Los Angeles, where he worked with Dr. Steven E. Jacobsen to study the epigenetic regulation of transposons in plants. He then performed his postdoctoral research at Harvard Medical School where he worked with Dr. Michael E. Greenberg to study transcriptional programs controlling neuronal development. In 2021, he joined UT Southwestern as an Assistant Professor.


The Stroud lab seeks to elucidate the genetic programs that control the development and homeostasis of the nervous system. The lab is particularly interested in understanding how environmental cues modulate these programs, and in using this information to understand and treat neurological disorders.


Stroud Lab website:

Research Interest

  • Epigenetics
  • Genome engineering
  • Neurological disorders
  • Single-cell genomics


Featured Publications LegendFeatured Publications

An Activity-Mediated Transition in Transcription in Early Postnatal Neurons.
Stroud H, Yang MG, Tsitohay YN, Davis CP, Sherman MA, Hrvatin S, Ling E, Greenberg ME, Neuron 2020 09 107 5 874-890.e8
Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States.
Stroud H, Su SC, Hrvatin S, Greben AW, Renthal W, Boxer LD, Nagy MA, Hochbaum DR, Kinde B, Gabel HW, Greenberg ME, Cell 2017 Nov 171 5 1151-1164.e16
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis.
Stroud H, Do T, Du J, Zhong X, Feng S, Johnson L, Patel DJ, Jacobsen SE Nat. Struct. Mol. Biol. 2014 Jan 21 1 64-72
Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome.
Stroud H, Greenberg MV, Feng S, Bernatavichute YV, Jacobsen SE Cell 2013 Jan 152 1-2 352-64

Honors & Awards

  • SFARI Bridge to Independence Award
  • Charles A. King Trust Postdoctoral Fellowship
  • Mahoney Neuroscience Institute Fund Award
  • NARSAD Young Investigator Award
  • William Randolph Hearst Fund Award
  • Damon Runyon Cancer Research Foundation Fellowship