Over the past 25 years, cardiologist Darren McGuire, M.D., M.H.Sc., has worked together with a small but powerful – and growing – group of clinical researchers around the world who have changed the landscape for diabetes patient care.
Today we know that people with Type 2 diabetes are twice as likely as other people to develop heart disease and stroke, but when Dr. McGuire began his career, there were no clinical studies showing how diabetes treatments affect heart disease and stroke.
“It was a complete desert for clinical outcomes data,” he recalls, noting that diabetes medications were judged solely on their ability to affect the levels of glucose in the blood. “We had no data that proved whether or not changing a person’s blood sugar level actually made that person live longer or feel better from a cardiovascular perspective.”
So he set out to change that. Dr. McGuire scoured the globe seeking people who had an interest in conducting large-scale, international clinical trials, like the work he was training to do while at the Duke Clinical Research Institute.
Through the resulting collaborations, these early efforts of Dr. McGuire and collaborators around the globe have taken the number of clinical outcomes trials for diabetes and heart disease from zero to more than 20 initiated over the past 10 years.
“We’ve had amazing success,” he says. “Until six months ago there was not a single positive cardiovascular clinical outcomes trial in the entire field of diabetes research. Now we have four different diabetes medications that have been statistically proven to improve patient outcomes in terms of heart attack, death, and stroke, all reported just since September 2015.”
Having a vibrant, leading-edge research program gives Dr. McGuire an advantage in offering the latest treatment strategies for diabetes patients in his cardiology clinic. His research proves that it’s valuable for patients with diabetes to see a cardiologist who specializes in diabetes.
“We can make nuanced distinctions about the medications we use for heart conditions – what might be more effective in patients with diabetes and whether those medications will affect the medications we may also be using for blood sugar control,” he says.
Dr. McGuire expects today’s clinical trials will continue to shape and reshape the future of diabetes treatment.
“It’s been a community effort,” he says of the groundbreaking research he has contributed to. “Our international group of clinical researchers has been working together for 20 years now – these are some of my best friends in the world, and we’re communicating back and forth regularly about how we can take the next step forward. To me, the future has never been more exciting.
“UT Southwestern’s motto is The future of medicine, today, and I like to think that’s what my patients get when they come to my clinic. It’s not just the goal; we’re actually generating the future of medicine in our research and clinical work – in my case, for patients with diabetes and heart disease.”
- Medical School
- Johns Hopkins University School of Medicine (1993)
- UT Southwestern Medical Center (1994), Internal Medicine
- UT Southwestern Medical Center (1996), Internal Medicine
- UT Southwestern Medical Center (1997), Cardiology
- Duke University School of Medicine (2001), Cardiology
- Cardiovascular Clinical Outcomes trials
- Diabetes and Vascular Disease
- Disparities in health care and outcomes by race and sex
- Epidemiology of coronary heart disease risk and prevention
- Resolving drug effects from class effects among drugs for type 2 diabetes mellitus: more support for cardiovascular outcome assessments.
- Gore MO, McGuire DK European heart journal 2011 Aug 32 15 1832-4
- No association between hemoglobin A1c and in-hospital mortality in patients with diabetes and acute myocardial infarction.
- Britton KA, Aggarwal V, Chen AY, Alexander KP, Amsterdam E, Fraulo E, Muntner P, Thomas L, McGuire DK, Wiviott SD, Roe MT, Schubart UK, Fox CS Am. Heart J. 2011 Apr 161 4 657-663.e1
- Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study.
- Banks K, Puttagunta D, Murphy S, Lo M, McGuire DK, de Lemos JA, Chang AY, Grundy SM, Khera A JACC Cardiovasc Imaging 2011 Jan 4 1 65-73
- Glucose-lowering targets for patients with cardiovascular disease: focus on inpatient management of patients with acute coronary syndromes.
- Kosiborod M, McGuire DK Circulation 2010 Dec 122 25 2736-44
- Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.
- de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, Hashim I, Berry JD, Das SR, Morrow DA, McGuire DK JAMA 2010 Dec 304 22 2503-12
- Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function.
- McGuire DK, Abdullah SM, See R, Snell PG, McGavock J, Szczepaniak LS, Ayers CR, Drazner MH, Khera A, de Lemos JA Eur. Heart J. 2010 Sep 31 18 2262-70
- Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study.
- Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK Diabetes Care 2009 Jul 32 7 1218-20
- Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial.
- Morrow DA, Scirica BM, Chaitman BR, McGuire DK, Murphy SA, Karwatowska-Prokopczuk E, McCabe CH, Braunwald E Circulation 2009 Apr 119 15 2032-9
- Evaluation of the Glycometabolic Effects of Ranolazine in Patients With and Without Diabetes Mellitus in the MERLIN-TIMI 36 Randomized Controlled Trial.
- Morrow DA, Scirica BM, Chaitman BR, McGuire DK, Murphy SA, Karwatowska-Prokopczuk E, McCabe CH, Braunwald E Circulation 2009 119 20032-20039
- Association Between Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) and Risk for Atherosclerosis: the Dallas Heart Study
- Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK. Diabetes Care 2009 32 1218-1220
Diabetes and the cardiovascular system. In Braunwald?s Heart Disease: A textbook of cardiovascular medicine 10E
McGuire DK. (2015). Philadelphia, Saunders Elsevier
American College of Cardiology Foundation Diabetes Self-Assessment Program
edited by McGuire DK and Sperling L (Ed.) (2011). Washington DC, American College of Cardiology Foundation, 2011
Diabetes in Cardiovascular Disease: A Companion to Braunwald?s Heart Disease
edited by McGuire DK and Marx N. (Ed.) (2014). Philadelphia, PA:, Saunders, an imprint of Elsevier Inc
Epidemiology of Diabetes Mellitus and Cardiovascular Disease in. In The Textbook of Diabetes Mellitus and Cardiovascular Disease. David Stern and Steven P. Marso, editors.
Rao SV, McGuire DK. (2003). Philadelphia, Lippincott Williams & Wilkins
Cardiovascular Considerations for the Use of Thiazolidinedione Medications,. In Harrison?s Online Textbook of Internal Medicine, 17e
McGuire DK, Inzucchi SE. (2009). edited by Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, and Loscalzo J.
Diabetes and the cardiovascular system. In Braunwald?s Heart Disease: A textbook of cardiovascular medicine 9E
McGuire DK. (2010). Philadelphia, Saunders Elsevier, 2010.
Honors & Awards
- Regents Outstanding Teaching Award
UT System Board of Regents (2013)
- L. David Hillis Award for Excellence in Teaching
UT Southwestern Cardiology Fellowship (2012)
- Outstanding Research Mentor Award
UT Southwestern Internal Medicine Housestaff (2012)
- Outstanding Research Mentor Award
UT Southwestern Internal Medicine Housestaff (2011)
- Hendrix College Odyssey Award in Research
Career Achievement in Clinical Research (2009)
- Outstanding Teacher Award
UT Southwestern Senior Medical Student Class (2008)
- Outstanding Teacher Award
UT Southwestern Internal Medicine Housestaff (2006)
- Outstanding Fellow in Clinical Research
Duke University Cardiology Fellowship Award (2001)
- Alpha Omega Alpha Medical Honor Society
Johns Hopkins University School of Medicine (1993)
- American Diabetes Association
- Fellow, American College of Cardiology
- Fellow, American Heart Association