Over the past 25 years, cardiologist Darren McGuire, M.D., M.H.Sc., has worked together with a small but powerful – and growing – group of clinical researchers around the world who have changed the landscape for diabetes patient care.
Today we know that people with Type 2 diabetes are twice as likely as other people to develop heart disease and stroke, but when Dr. McGuire began his career, there were no clinical studies showing how diabetes treatments affect heart disease and stroke.
“It was a complete desert for clinical outcomes data,” he recalls, noting that diabetes medications were judged solely on their ability to affect the levels of glucose in the blood. “We had no data that proved whether or not changing a person’s blood sugar level actually made that person live longer or feel better from a cardiovascular perspective.”
So he set out to change that. Dr. McGuire scoured the globe seeking people who had an interest in conducting large-scale, international clinical trials, like the work he was training to do while at the Duke Clinical Research Institute.
Through the resulting collaborations, these early efforts of Dr. McGuire and collaborators around the globe have taken the number of clinical outcomes trials for diabetes and heart disease from zero to more than 20 initiated over the past 10 years.
“We’ve had amazing success,” he says. “Until six months ago there was not a single positive cardiovascular clinical outcomes trial in the entire field of diabetes research. Now we have four different diabetes medications that have been statistically proven to improve patient outcomes in terms of heart attack, death, and stroke, all reported just since September 2015.”
Having a vibrant, leading-edge research program gives Dr. McGuire an advantage in offering the latest treatment strategies for diabetes patients in his cardiology clinic. His research proves that it’s valuable for patients with diabetes to see a cardiologist who specializes in diabetes.
“We can make nuanced distinctions about the medications we use for heart conditions – what might be more effective in patients with diabetes and whether those medications will affect the medications we may also be using for blood sugar control,” he says.
Dr. McGuire expects today’s clinical trials will continue to shape and reshape the future of diabetes treatment.
“It’s been a community effort,” he says of the groundbreaking research he has contributed to. “Our international group of clinical researchers has been working together for 20 years now – these are some of my best friends in the world, and we’re communicating back and forth regularly about how we can take the next step forward. To me, the future has never been more exciting.
“UT Southwestern’s motto is The future of medicine, today, and I like to think that’s what my patients get when they come to my clinic. It’s not just the goal; we’re actually generating the future of medicine in our research and clinical work – in my case, for patients with diabetes and heart disease.”
- Medical School
- Johns Hopkins University School of Medicine (1993)
- UT Southwestern Medical Center (1994), Internal Medicine
- UT Southwestern Medical Center (1996), Internal Medicine
- UT Southwestern Medical Center (1997), Cardiology
- Duke University School of Medicine (2001), Cardiology
- Cardiovascular Clinical Outcomes trials
- Diabetes and Vascular Disease
- Disparities in health care and outcomes by race and sex
- Epidemiology of coronary heart disease risk and prevention
- Effects of Ranolazine on Quality of Life Among Patients With Diabetes Mellitus and Stable Angina.
- Arnold SV, Kosiborod M, McGuire DK, Li Y, Yue P, Ben-Yehuda O, Spertus JA JAMA Intern Med 2014 Jun
- Age and Sex Dependent Upper Reference Limits for the High Sensitivity Cardiac Troponin T Assay.
- Gore MO, Seliger SL, Defilippi CR, Nambi V, Christenson RH, Hashim IA, Hoogeveen RC, Ayers CR, Sun W, McGuire DK, Ballantyne CM, de Lemos JA J. Am. Coll. Cardiol. 2014 Jan
- Glycated hemoglobin in 14,850 adolescent blood donors: a pilot screening program.
- Gore MO, Eason SJ, Ayers CR, Turer A, Khera A, de Lemos JA, McGuire DK, Sayers M Diabetes Care 2014 Jan 37 1 e3-4
- Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study.
- Gore MO, Lüneburg N, Schwedhelm E, Ayers CR, Anderssohn M, Khera A, Atzler D, de Lemos JA, Grant PJ, McGuire DK, Böger RH Arterioscler. Thromb. Vasc. Biol. 2013 Nov 33 11 2682-8
- Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
- Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I N. Engl. J. Med. 2013 Oct 369 14 1317-26
- Inaccuracy of Estimated Resting Oxygen Uptake in the Clinical Setting.
- Narang N, Thibodeau JT, Levine BD, Gore MO, Ayers CR, Lange RA, Cigarroa JE, Turer AT, de Lemos JA, McGuire DK Circulation 2013 Sep
- Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.
- Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB Circulation 2013 Jan 127 1 143-52
- Diabetes mellitus and trends in hospital survival after myocardial infarction, 1994 to 2006: data from the national registry of myocardial infarction.
- Gore MO, Patel MJ, Kosiborod M, Parsons LS, Khera A, de Lemos JA, Rogers WJ, Peterson ED, Canto JC, McGuire DK Circ Cardiovasc Qual Outcomes 2012 Nov 5 6 791-7
- Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.
- Roe MT, Armstrong PW, Fox KA, White HD, Prabhakaran D, Goodman SG, Cornel JH, Bhatt DL, Clemmensen P, Martinez F, Ardissino D, Nicolau JC, Boden WE, Gurbel PA, Ruzyllo W, Dalby AJ, McGuire DK, Leiva-Pons JL, Parkhomenko A, Gottlieb S, Topacio GO, Hamm C, Pavlides G, Goudev AR, Oto A, Tseng CD, Merkely B, Gasparovic V, Corbalan R, Cinteza M, McLendon RC, Winters KJ, Brown EB, Lokhnygina Y, Aylward PE, Huber K, Hochman JS, Ohman EM N. Engl. J. Med. 2012 Oct 367 14 1297-309
- Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults.
- Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA JAMA 2012 Sep 308 11 1150-9
Diabetes and the cardiovascular system. In Braunwald?s Heart Disease: A textbook of cardiovascular medicine 10E
McGuire DK. (2015). Philadelphia, Saunders Elsevier
American College of Cardiology Foundation Diabetes Self-Assessment Program
edited by McGuire DK and Sperling L (Ed.) (2011). Washington DC, American College of Cardiology Foundation, 2011
Diabetes in Cardiovascular Disease: A Companion to Braunwald?s Heart Disease
edited by McGuire DK and Marx N. (Ed.) (2014). Philadelphia, PA:, Saunders, an imprint of Elsevier Inc
Epidemiology of Diabetes Mellitus and Cardiovascular Disease in. In The Textbook of Diabetes Mellitus and Cardiovascular Disease. David Stern and Steven P. Marso, editors.
Rao SV, McGuire DK. (2003). Philadelphia, Lippincott Williams & Wilkins
Cardiovascular Considerations for the Use of Thiazolidinedione Medications,. In Harrison?s Online Textbook of Internal Medicine, 17e
McGuire DK, Inzucchi SE. (2009). edited by Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, and Loscalzo J.
Diabetes and the cardiovascular system. In Braunwald?s Heart Disease: A textbook of cardiovascular medicine 9E
McGuire DK. (2010). Philadelphia, Saunders Elsevier, 2010.
Honors & Awards
- Regents Outstanding Teaching Award
UT System Board of Regents (2013)
- L. David Hillis Award for Excellence in Teaching
UT Southwestern Cardiology Fellowship (2012)
- Outstanding Research Mentor Award
UT Southwestern Internal Medicine Housestaff (2012)
- Outstanding Research Mentor Award
UT Southwestern Internal Medicine Housestaff (2011)
- Hendrix College Odyssey Award in Research
Career Achievement in Clinical Research (2009)
- Outstanding Teacher Award
UT Southwestern Senior Medical Student Class (2008)
- Outstanding Teacher Award
UT Southwestern Internal Medicine Housestaff (2006)
- Outstanding Fellow in Clinical Research
Duke University Cardiology Fellowship Award (2001)
- Alpha Omega Alpha Medical Honor Society
Johns Hopkins University School of Medicine (1993)
- American Diabetes Association
- Fellow, American College of Cardiology
- Fellow, American Heart Association