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Over the past 25 years, cardiologist Darren McGuire, M.D., M.H.Sc., has worked together with a small but powerful – and growing – group of clinical researchers around the world who have changed the landscape for diabetes patient care.

Today we know that people with Type 2 diabetes are twice as likely as other people to develop heart disease and stroke, but when Dr. McGuire began his career, there were no clinical studies showing how diabetes treatments affect heart disease and stroke.

“It was a complete desert for clinical outcomes data,” he recalls, noting that diabetes medications were judged solely on their ability to affect the levels of glucose in the blood. “We had no data that proved whether or not changing a person’s blood sugar level actually made that person live longer or feel better from a cardiovascular perspective.”

Pioneering Research

So he set out to change that. Dr. McGuire scoured the globe seeking people who had an interest in conducting large-scale, international clinical trials, like the work he was training to do while at the Duke Clinical Research Institute.

Through the resulting collaborations, these early efforts of Dr. McGuire and collaborators around the globe have taken the number of clinical outcomes trials for diabetes and heart disease from zero to more than 20 initiated over the past 10 years.

“We’ve had amazing success,” he says. “Until six months ago there was not a single positive cardiovascular clinical outcomes trial in the entire field of diabetes research. Now we have four different diabetes medications that have been statistically proven to improve patient outcomes in terms of heart attack, death, and stroke, all reported just since September 2015.”

Having a vibrant, leading-edge research program gives Dr. McGuire an advantage in offering the latest treatment strategies for diabetes patients in his cardiology clinic. His research proves that it’s valuable for patients with diabetes to see a cardiologist who specializes in diabetes.

“We can make nuanced distinctions about the medications we use for heart conditions – what might be more effective in patients with diabetes and whether those medications will affect the medications we may also be using for blood sugar control,” he says.

Dr. McGuire expects today’s clinical trials will continue to shape and reshape the future of diabetes treatment.

“It’s been a community effort,” he says of the groundbreaking research he has contributed to. “Our international group of clinical researchers has been working together for 20 years now – these are some of my best friends in the world, and we’re communicating back and forth regularly about how we can take the next step forward. To me, the future has never been more exciting.

“UT Southwestern’s motto is The future of medicine, today, and I like to think that’s what my patients get when they come to my clinic. It’s not just the goal; we’re actually generating the future of medicine in our research and clinical work – in my case, for patients with diabetes and heart disease.”


Medical School
Johns Hopkins University School of Medicine (1993)
UT Southwestern Medical Center (1994), Internal Medicine
UT Southwestern Medical Center (1996), Internal Medicine
UT Southwestern Medical Center (1997), Cardiology
Duke University School of Medicine (2001), Cardiology

Research Interest

  • Cardiovascular Clinical Outcomes trials
  • Diabetes and Vascular Disease
  • Disparities in health care and outcomes by race and sex
  • Epidemiology of coronary heart disease risk and prevention


Featured Publications LegendFeatured Publications

Predicting Adverse Outcomes After Myocardial Infarction Among Patients With Diabetes Mellitus.
Arnold SV, Spertus JA, Jones PG, McGuire DK, Lipska KJ, Xu Y, Stolker JM, Goyal A, Kosiborod M Circ Cardiovasc Qual Outcomes 2016 May
Revascularization Trends in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Presenting With Non-ST Elevation Myocardial Infarction: Insights From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get with the Guidelines (NCDR ACTION Registry-GWTG).
Pandey A, McGuire DK, de Lemos JA, Das SR, Berry JD, Brilakis ES, Banerjee S, Marso SP, Barsness GW, Simon DN, Roe M, Goyal A, Kosiborod M, Amsterdam EA, Kumbhani DJ Circ Cardiovasc Qual Outcomes 2016 May 9 3 197-205
High prevalence of elevated haemoglobin A1C among adolescent blood donors: Results from a voluntary screening programme including 31,546 adolescents.
Gore MO, Eason SJ, Ayers CR, Turer AT, Khera A, de Lemos JA, McGuire DK, Sayers M Diab Vasc Dis Res 2015 Jul 12 4 272-8
Metabolic Effects of Exercise Training Among Fitness Nonresponsive Patients With Type 2 Diabetes Mellitus: The HART-D Study.
Pandey A, Swift DL, McGuire DK, Ayers CR, Neeland IJ, Blair SN, Johannsen N, Earnest CP, Berry JD, Church TS Diabetes Care 2015 Jun
Body fat distribution and incident cardiovascular disease in obese adults.
Neeland IJ, Turer AT, Ayers CR, Berry JD, Rohatgi A, Das SR, Khera A, Vega GL, McGuire DK, Grundy SM, de Lemos JA J. Am. Coll. Cardiol. 2015 May 65 19 2150-1
Metformin in patients with type 2 diabetes and kidney disease: a systematic review.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK JAMA 2014 Dec 24-31 312 24 2668-75
Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial.
Udell JA, Bhatt DL, Braunwald E, Cavender MA, Mosenzon O, Steg PG, Davidson JA, Nicolau JC, Corbalan R, Hirshberg B, Frederich R, Im K, Umez-Eronini AA, He P, McGuire DK, Leiter LA, Raz I, Scirica BM Diabetes Care 2014 Dec
The relationship of body mass and fat distribution with incident hypertension: observations from the dallas heart study.
Chandra A, Neeland IJ, Berry JD, Ayers CR, Rohatgi A, Das SR, Khera A, McGuire DK, de Lemos JA, Turer AT J. Am. Coll. Cardiol. 2014 Sep 64 10 997-1002
Heart Failure, Saxagliptin and Diabetes Mellitus: Observations from the SAVOR - TIMI 53 Randomized Trial.
Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL Circulation 2014 Sep
Contemporary Patterns of Discharge Aspirin Dosing After Acute Myocardial Infarction in the United States: Results From the National Cardiovascular Data Registry (NCDR).
Hall HM, de Lemos JA, Enriquez JR, McGuire DK, Peng SA, Alexander KP, Roe MT, Desai N, Wiviott SD, Das SR Circ Cardiovasc Qual Outcomes 2014 Aug


Featured Books Legend Featured Books

Epidemiology of Diabetes Mellitus and Cardiovascular Disease in. In The Textbook of Diabetes Mellitus and Cardiovascular Disease. David Stern and Steven P. Marso, editors.

Rao SV, McGuire DK. (2003). Philadelphia, Lippincott Williams & Wilkins

Cardiovascular Considerations for the Use of Thiazolidinedione Medications,. In Harrison?s Online Textbook of Internal Medicine, 17e

McGuire DK, Inzucchi SE. (2009). edited by Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, and Loscalzo J.

Diabetes and the cardiovascular system. In Braunwald?s Heart Disease: A textbook of cardiovascular medicine 9E

McGuire DK. (2010). Philadelphia, Saunders Elsevier, 2010.

Honors & Awards

  • Regents Outstanding Teaching Award
    UT System Board of Regents (2013)
  • L. David Hillis Award for Excellence in Teaching
    UT Southwestern Cardiology Fellowship (2012)
  • Outstanding Research Mentor Award
    UT Southwestern Internal Medicine Housestaff (2012)
  • Outstanding Research Mentor Award
    UT Southwestern Internal Medicine Housestaff (2011)
  • Hendrix College Odyssey Award in Research
    Career Achievement in Clinical Research (2009)
  • Outstanding Teacher Award
    UT Southwestern Senior Medical Student Class (2008)
  • Outstanding Teacher Award
    UT Southwestern Internal Medicine Housestaff (2006)
  • Outstanding Fellow in Clinical Research
    Duke University Cardiology Fellowship Award (2001)
  • Alpha Omega Alpha Medical Honor Society
    Johns Hopkins University School of Medicine (1993)

Professional Associations/Affiliations

  • American Diabetes Association
  • Fellow, American College of Cardiology
  • Fellow, American Heart Association