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Darren K. McGuire, M.D., M.H.Sc., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Cardiology. He is also the Director of the Parkland Hospital and Health System Outpatient Cardiology clinics.

Dr. McGuire earned his medical degree at the Johns Hopkins University School of Medicine and completed an internal medicine residency at UT Southwestern. He then received advanced training in cardiology through a fellowship at Duke University, where he also conducted research for two years, working on a number of large-scale, international clinical trials and registries at the Duke Clinical Research Institute (DCRI). He also earned a master’s degree in health sciences in clinical trials at the Duke University School of Medicine.

He joined the cardiology faculty at UT Southwestern in 2001. His main clinical and research interests are in the long-term prevention of and risk-modification for cardiovascular disease, especially among patients with diabetes. His research has led to more than 100 publications in peer-reviewed journals. 

Dr. McGuire is Deputy Editor of Circulation, Senior Editor of Diabetes and Vascular Disease Research, and editor of the textbook Diabetes in Cardiovascular Disease: a companion to Braunwald’s Heart Disease.

He is a Fellow of the American Heart Association (AHA), the American College of Cardiology and the European Society of Cardiology; a former Chair of the AHA Diabetes Committee; and a former member of and present ad hoc consultant for the FDA Cardiovascular and Renal Drugs Advisory Committee.

Dr. McGuire has received numerous teaching awards, most notably the UT System Board of Regents Outstanding Teaching Award in 2013.


Medical School
Johns Hopkins University School of Medicine (1993)
UT Southwestern Medical Center (1994), Internal Medicine
UT Southwestern Medical Center (1996), Internal Medicine
UT Southwestern Medical Center (1997), Cardiology
Duke University School of Medicine (2001), Cardiology

Research Interest

  • Cardiovascular Clinical Outcomes trials
  • Diabetes and Vascular Disease
  • Disparities in health care and outcomes by race and sex
  • Epidemiology of coronary heart disease risk and prevention


Featured Publications LegendFeatured Publications

Predicting Adverse Outcomes After Myocardial Infarction Among Patients With Diabetes Mellitus.
Arnold SV, Spertus JA, Jones PG, McGuire DK, Lipska KJ, Xu Y, Stolker JM, Goyal A, Kosiborod M Circ Cardiovasc Qual Outcomes 2016 May
Revascularization Trends in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Presenting With Non-ST Elevation Myocardial Infarction: Insights From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get with the Guidelines (NCDR ACTION Registry-GWTG).
Pandey A, McGuire DK, de Lemos JA, Das SR, Berry JD, Brilakis ES, Banerjee S, Marso SP, Barsness GW, Simon DN, Roe M, Goyal A, Kosiborod M, Amsterdam EA, Kumbhani DJ Circ Cardiovasc Qual Outcomes 2016 May 9 3 197-205
High prevalence of elevated haemoglobin A1C among adolescent blood donors: Results from a voluntary screening programme including 31,546 adolescents.
Gore MO, Eason SJ, Ayers CR, Turer AT, Khera A, de Lemos JA, McGuire DK, Sayers M Diab Vasc Dis Res 2015 Jul 12 4 272-8
Metabolic Effects of Exercise Training Among Fitness Nonresponsive Patients With Type 2 Diabetes Mellitus: The HART-D Study.
Pandey A, Swift DL, McGuire DK, Ayers CR, Neeland IJ, Blair SN, Johannsen N, Earnest CP, Berry JD, Church TS Diabetes Care 2015 Jun
Body fat distribution and incident cardiovascular disease in obese adults.
Neeland IJ, Turer AT, Ayers CR, Berry JD, Rohatgi A, Das SR, Khera A, Vega GL, McGuire DK, Grundy SM, de Lemos JA J. Am. Coll. Cardiol. 2015 May 65 19 2150-1
Metformin in patients with type 2 diabetes and kidney disease: a systematic review.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK JAMA 2014 Dec 24-31 312 24 2668-75
Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial.
Udell JA, Bhatt DL, Braunwald E, Cavender MA, Mosenzon O, Steg PG, Davidson JA, Nicolau JC, Corbalan R, Hirshberg B, Frederich R, Im K, Umez-Eronini AA, He P, McGuire DK, Leiter LA, Raz I, Scirica BM Diabetes Care 2014 Dec
The relationship of body mass and fat distribution with incident hypertension: observations from the dallas heart study.
Chandra A, Neeland IJ, Berry JD, Ayers CR, Rohatgi A, Das SR, Khera A, McGuire DK, de Lemos JA, Turer AT J. Am. Coll. Cardiol. 2014 Sep 64 10 997-1002
Heart Failure, Saxagliptin and Diabetes Mellitus: Observations from the SAVOR - TIMI 53 Randomized Trial.
Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL Circulation 2014 Sep
Contemporary Patterns of Discharge Aspirin Dosing After Acute Myocardial Infarction in the United States: Results From the National Cardiovascular Data Registry (NCDR).
Hall HM, de Lemos JA, Enriquez JR, McGuire DK, Peng SA, Alexander KP, Roe MT, Desai N, Wiviott SD, Das SR Circ Cardiovasc Qual Outcomes 2014 Aug


Featured Books Legend Featured Books

Epidemiology of Diabetes Mellitus and Cardiovascular Disease in. In The Textbook of Diabetes Mellitus and Cardiovascular Disease. David Stern and Steven P. Marso, editors.

Rao SV, McGuire DK. (2003). Philadelphia, Lippincott Williams & Wilkins

Cardiovascular Considerations for the Use of Thiazolidinedione Medications,. In Harrison?s Online Textbook of Internal Medicine, 17e

McGuire DK, Inzucchi SE. (2009). edited by Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, and Loscalzo J.

Diabetes and the cardiovascular system. In Braunwald?s Heart Disease: A textbook of cardiovascular medicine 9E

McGuire DK. (2010). Philadelphia, Saunders Elsevier, 2010.

Honors & Awards

  • Regents Outstanding Teaching Award
    UT System Board of Regents (2013)
  • L. David Hillis Award for Excellence in Teaching
    UT Southwestern Cardiology Fellowship (2012)
  • Outstanding Research Mentor Award
    UT Southwestern Internal Medicine Housestaff (2012)
  • Outstanding Research Mentor Award
    UT Southwestern Internal Medicine Housestaff (2011)
  • Hendrix College Odyssey Award in Research
    Career Achievement in Clinical Research (2009)
  • Outstanding Teacher Award
    UT Southwestern Senior Medical Student Class (2008)
  • Outstanding Teacher Award
    UT Southwestern Internal Medicine Housestaff (2006)
  • Outstanding Fellow in Clinical Research
    Duke University Cardiology Fellowship Award (2001)
  • Alpha Omega Alpha Medical Honor Society
    Johns Hopkins University School of Medicine (1993)

Professional Associations/Affiliations

  • American Diabetes Association
  • Fellow, American College of Cardiology
  • Fellow, American Heart Association