Jin Zhou, Ph.D.

 Featured Publications

USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.

Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q, Proc Natl Acad Sci U S A 2022 Sep 119 36 e2119854119

An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.

Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap VT, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q, Mol Cell 2022 Jun

Prenatal ethanol exposure increases maternal bile acids through placental transport pathway.

Liu F, Zhou J, Guo J, Huang W, Zhang W, Wang H, Toxicology 2021 06 458 152848

Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters.

Huang W, Zhou J, Guo J, Hu W, Chen G, Li B, Wen Y, Jiang Y, Fu K, Bi H, Zhang Y, Wang H, BMC Med 2021 Apr 19 1 87

Two intrauterine programming mechanisms of adult hypercholesterolemia induced by prenatal nicotine exposure in male offspring rats.

Zhou J, Zhu C, Luo H, Shen L, Gong J, Wu Y, Magdalou J, Chen L, Guo Y, Wang H, FASEB J 2019 Jan 33 1 1110-1123

Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats.

Zhang G, Zhou J, Huang W, Yu L, Zhang Y, Wang H Toxicol. Lett. 2018 Jul

cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11?-HSD2 expression.

Yu L, Zhou J, Zhang G, Huang W, Pei L, Lv F, Zhang Y, Zhang W, Wang H Toxicol. Appl. Pharmacol. 2018 May 352 77-86

nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11?-HSD2.

Zhou J, Liu F, Yu L, Xu D, Li B, Zhang G, Huang W, Li L, Zhang Y, Zhang W, Wang H Toxicol. Appl. Pharmacol. 2018 Apr 344 1-12

Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.

Zhang C, Yu M, Hepperla AJ, Zhang Z, Raj R, Zhong H, Zhou J, Hu L, Fang J, Liu H, Liang Q, Jia L, Liao C, Xi S, Simon JM, Xu K, Liu Z, Nam Y, Kapur P, Zhang Q, J Clin Invest 2024 Apr 134 8

Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.

Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q, Mol Cell 2024 Feb 84 4 776-790.e5

• AACR-Exelixis Renal Cell Carcinoma Research Fellowship
  (2022-2024)
• Second Prize in the Youth Paper Presentation Competition at the 15th National Conference on Biochemistry and Molecular Pharmacology
  (2018)
• First Prize in the Youth Paper Presentation Competition at the 2017 Academic Conference of the Hubei & Wuhan Pharmaceutical Association
  (2017)
• Wuhan University Ph.D. Independent Scientific Research (Key) Project
  (2015-2018)

• American Association for Cancer Research (2020)