Samuel Pappas, Ph.D.
Department Peter O’Donnell Jr. Brain Institute | Neurology
Dr. Pappas is an Assistant Professor in the Peter O’Donnell Jr. Brain Institute at UT Southwestern Medical Center. Dr. Pappas earned his Bachelor of Science and Ph.D. in Physiology at Michigan State University. He pursued postdoctoral work at University of Michigan in the laboratory of Dr. William Dauer, where he studied novel animal models of inherited dystonia.
Dr. Pappas’ current work is focused on unraveling the mechanisms of selective neurodegeneration, defining the role cholinergic neuron dysfunction in dystonia, and identifying of novel therapeutic targets for movement disorders. To address these questions, his team uses animal and cell culture based disease models and a combination of molecular, cellular, neuroanatomical, and behavioral methods.
- Mechanisms of neurodegeneration
- Parkinson's disease
- TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models.
- Li J, Liang CC, Pappas SS, Dauer WT, Elife 2020 Mar 9
- A cell autonomous torsinA requirement for cholinergic neuron survival and motor control.
- Pappas SS, Li J, LeWitt TM, Kim JK, Monani UR, Dauer WT, Elife 2018 08 7
- TorsinA dysfunction causes persistent neuronal nuclear pore defects.
- Pappas SS, Liang CC, Kim S, Rivera CO, Dauer WT, Hum. Mol. Genet. 2018 02 27 3 407-420
- The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.
- Yellajoshyula D, Liang CC, Pappas SS, Penati S, Yang A, Mecano R, Kumaran R, Jou S, Cookson MR, Dauer WT, Dev. Cell 2017 07 42 1 52-67.e4
- Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons.
- Pappas SS, Darr K, Holley SM, Cepeda C, Mabrouk OS, Wong JM, LeWitt TM, Paudel R, Houlden H, Kennedy RT, Levine MS, Dauer WT, Elife 2015 Jun 4 e08352
- Inherited dystonias: clinical features and molecular pathways.
- Weisheit CE, Pappas SS, Dauer WT, Handb Clin Neurol 2018 147 241-254
- Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia.
- DeSimone JC, Pappas SS, Febo M, Burciu RG, Shukla P, Colon-Perez LM, Dauer WT, Vaillancourt DE, Neurobiol. Dis. 2017 Oct 106 124-132
- Microfabrication and in Vivo Performance of a Microdialysis Probe with Embedded Membrane.
- Lee WH, Ngernsutivorakul T, Mabrouk OS, Wong JM, Dugan CE, Pappas SS, Yoon HJ, Kennedy RT, Anal. Chem. 2016 Jan 88 2 1230-7
- Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice.
- Luna-Cancalon K, Sikora KM, Pappas SS, Singh V, Wulff H, Paulson HL, Burmeister M, Shakkottai VG, Neurobiol. Dis. 2014 Jul 67 140-8
- Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits.
- Pappas SS, Leventhal DK, Albin RL, Dauer WT, Curr. Top. Dev. Biol. 2014 109 97-169