Ravikanth “Ravi” Maddipati, M.D. Titles and Appointments Assistant Professor Schools Medical School | Graduate School Departments Internal Medicine | Children's Medical Center Research Institute at UT Southwestern Graduate Programs Cancer Biology, Genetics, Development and Disease Biography Download Curriculum Vitae Ravikanth Maddipati, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Digestive and Liver Diseases. His clinical interests are in pancreatic disorders, including pancreatitis and pancreatic cancer, cancer genetics, screening of high risk and hereditary gastrointestinal malignances, and general gastroenterology. Dr. Maddipati holds a bachelor's degree in computer and electrical engineering from the University of Michigan, where he graduated magna cum laude. He remained there to obtain a master's degree in biomedical engineering. He earned his medical degree with honors from Boston University School of Medicine and completed internal medicine residency training at Massachusetts General Hospital. He then received advanced training in gastroenterology through a fellowship at the University of Pennsylvania. Certified by the American Board of Internal Medicine, Dr. Maddipati joined the UT Southwestern faculty in 2019. His research interests include pancreatic cancer, tumor metastasis, and pancreatitis. Dr. Maddipati is a member of the American Association for Cancer Research, the American Association for the Study of Liver Diseases, the American Gastroenterological Association, the American Pancreatic Association, and the American Society for Gastrointestinal Endoscopy. Research Interest Cancer Metastasis Pancreatic Cancer Tumor Heterogeneity Tumor Immunology Tumor Metabolism Publications Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma Safari M, Scotto L, Basseville A, Litman T, Xue H, Petrukhin L, Zhou P, Remotti HE, Ku A, Morales DV, Damoci C, Zhu M, Maddipati R, Hull KG, Robey RW, Olive KP, Fojo T, Romo D, Bates SE Drug Resistance Updates 2026 Jan 84 Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention Maddipati R Journal of Clinical Investigation 2025 Jul 135 Ablative Radiation Therapy in Oligometastatic Pancreatic Cancer to Delay Polyprogression, Limit Chemotherapy, and Improve Outcomes Elamir AM, Karalis JD, Sanford NN, Polanco PM, Folkert MR, Porembka MR, Kazmi SA, Maddipati R, Zeh HJ, Timmerman RD, Zhang S, Ligorio M, Beg MS, Aguilera TA International Journal of Radiation Oncology Biology Physics 2022 Nov 114 792-802 Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer Huang H, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G, Wright S, Gu X, Maddipati R, Müller S, Turley SJ, Brekken RA Cancer Cell 2022 Jun 40 656-673.e7 MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Li J, Balli D, Lariviere MJ, Ngo TV, Folkert IW, Millstein ID, Bermeo J, Carpenter EL, McAuliffe JC, Oktay MH, Brekken RA, Lowe SW, Iacobuzio-Donahue CA, Notta F, Stanger BZ Cancer discovery 2022 Feb 12 542-561 APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis Wörmann SM, Zhang A, Thege FI, Cowan RW, Rupani DN, Wang R, Manning SL, Gates C, Wu W, Levin-Klein R, Rajapakshe KI, Yu M, Multani AS, Kang Y, Taniguchi CM, Schlacher K, Bellin MD, Katz MH, Kim MP, Fleming JB, Gallinger S, Maddipati R, Harris RS, Notta F, Ross SR, Maitra A, Rhim AD Nature Cancer 2021 Dec 2 1338-1356 Calcium signaling induces a partial EMT Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ EMBO Reports 2021 Sep 22 Cancer-associated fibroblasts: Versatile players in the tumor microenvironment Ganguly D, Chandra R, Karalis J, Teke M, Aguilera T, Maddipati R, Wachsmann MB, Ghersi D, Siravegna G, Zeh HJ, Brekken R, Ting DT, Ligorio M Cancers 2020 Sep 12 1-35 Pancreatic cancer survival analysis defines a signature that predicts outcome Raman P, Maddipati R, Lim KH, Tozeren A PloS one 2018 Aug 13 EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ Developmental cell 2018 Jun 45 681-695.e4 Results 1-10 of 20 1 2 Next Last Books Featured Books Liver and Pancreas: Mechanisms of Development and Size Control. In Stem Cells: From Basic Research to Therapy Maddipati, R., Stanger, B.Z (2014). Science Publishers Honors & Awards NIH Directors New Innovator Award-DP2Award to develop novel optogenetic based tools for in vivo tumor modeling and studies of tumor heterogeneity and metastasis. (2023) CPRIT Scholar in Cancer ResearchCancer Prevention Research Institute of Texas (2019) Disease Oriented Clinical ScholarDisease-Oriented Clinical Scholars (DOCS) program, UTSW (2019) Caroline Craig Augustyn & Damian Augustyn Award in Digestive CancerAmerican Gastroenterological Association (2018) Frank Brooks Excellence in Research AwardUniversity of Pennsylvania (2013) HHMI Medical Research ScholarHoward Hughes Medical Institute (2006) Professional Associations/Affiliations American Association of Cancer Research American Gastroenterological Association American Pancreas Association American Society for Gastrointestinal Endoscopy
